Oxidative damage prevention in human skin and sensory neurons by a salicylic acid derivative

Autor: Elodie Gras, Lavigne, Andrea, Cavagnino, Rémy, Steinschneider, Lionel, Breton, Martin A, Baraibar, Sibylle, Jäger

Publikováno v: Free Radical Biology and Medicine. 181:98-104

Increased protein carbonylation is a hallmark of oxidative stress, protein homeostasis dysregulation and aging in the nervous system and skin. Sensory neurons interact with skin cells and are involved in skin homeostasis. We have previously reported

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6b9d591025e13ba404aaed80e1a03dd4
https://doi.org/10.1016/j.freeradbiomed.2022.01.029

Neuroprotective activity of stiripentol with a possible involvement of voltage-dependent calcium and sodium channels

Autor: Dorothée Buttigieg, Marc Verleye, Rémy Steinschneider

Publikováno v: Journal of Neuroscience Research. 94:179-189

A growing body of data has shown that recurrent epileptic seizures may be caused by an excessive release of the excitatory neurotransmitter glutamate in the brain. Glutamatergic overstimulation results in massive neuronal influxes of calcium and sodi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::acdb7dd58ee8c5cb9347cde8b2998061
https://doi.org/10.1002/jnr.23688

Moclobemide attenuates anoxia and glutamate-induced neuronal damage in vitro independently of interaction with glutamate receptor subtypes

Autor: François Xavier Bernard, Rémy Steinschneider, Marc Verleye, Jean-Marie Gillardin

Publikováno v: Brain Research. 1138:30-38

Recent data suggested the existence of a bidirectional relation between depression and neurodegenerative diseases resulting from cerebral ischemia injury. Glutamate, a major excitatory neurotransmitter, has long been recognised to play a key role in

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e09ec1e711d63825060119a58bca1a55
https://doi.org/10.1016/j.brainres.2006.12.089

Combining two repurposed drugs as a promising approach for Alzheimer's disease therapy

Autor: Emmanuel Vial, Damien Toulorge, Nathalie Cholet, Yannick Pereira, Rémy Steinschneider, Esther Graudens, Tangui Maurice, Julie Foucquier, Rodolphe Hajj, Ilya Chumakov, Serguei Nabirotchkin, Aude Milet, Daniel Cohen, Catherine Scart-Grès, Aurélie Boucard, Noelle Callizot, Mickaël Guedj, Sory Traoré, Viviane Bertrand

Publikováno v: Scientific Reports
Scientific Reports, Nature Publishing Group, 2015, 5 (1), ⟨10.1038/srep07608⟩
Scientific Reports, 2015, 5 (1), ⟨10.1038/srep07608⟩

Alzheimer disease (AD) represents a major medical problem where mono-therapeutic interventions demonstrated only a limited efficacy so far. We explored the possibility of developing a combinational therapy that might prevent the degradation of neuron

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c97b170dd001135da9749208d50aa097
https://hal.archives-ouvertes.fr/hal-01922611

Operational dissection of β-amyloid cytopathic effects on cultured neurons

Autor: Philippe Poindron, Noelle Callizot, Rémy Steinschneider, Maud Combes

Publikováno v: Journal of neuroscience research. 91(5)

Alzheimer disease (AD) affects mainly people over the age of 65 years, suffering from different clinical symptoms such as progressive decline in memory, thinking, language, and learning capacity. The toxic role of β-amyloid peptide (Aβ) has now shi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9e7d755c603f82f6a146698c318c459a
https://pubmed.ncbi.nlm.nih.gov/23404368