Zobrazeno 1 - 10
of 13
pro vyhledávání: '"Rémi Guillon"'
Autor:
Rahila Rahimova, David Egron, Suzanne Peyrottes, Sonia Rouanet, Charles Dumontet, Lars Petter Jordheim, Laurent Chaloin, Nushin Aghajari, Preeti, Rémi Guillon
Publikováno v:
European Journal of Medicinal Chemistry
European Journal of Medicinal Chemistry, Elsevier, 2019, 168, pp.28-44. ⟨10.1016/j.ejmech.2019.02.040⟩
European Journal of Medicinal Chemistry, Elsevier, 2019, 168, pp.28-44. ⟨10.1016/J.EJMECH.2019.02.040⟩
European Journal of Medicinal Chemistry, Elsevier, 2019, 168, pp.28-44. ⟨10.1016/j.ejmech.2019.02.040⟩
European Journal of Medicinal Chemistry, Elsevier, 2019, 168, pp.28-44. ⟨10.1016/J.EJMECH.2019.02.040⟩
The development of cytosolic 5′-nucleotidase II (cN-II) inhibitors is essential to validate cN-II as a potential target for the reversion of resistance to cytotoxic nucleoside analogues. We previously reported a fragment-based approach combined wit
Autor:
David Montoir, Isabelle Ourliac-Garnier, Aurélien Planchat, Kossi Efouako Soklou, Carine Picot, Rémi Guillon, Sophie Gazzola, Alain Tonnerre, Cédric Logé, Fabrice Pagniez, Patrice Le Pape
Publikováno v:
European Journal of Medicinal Chemistry
European Journal of Medicinal Chemistry, Elsevier, 2020, 189, pp.112082. ⟨10.1016/j.ejmech.2020.112082⟩
European Journal of Medicinal Chemistry, Elsevier, 2020, 189, pp.112082. ⟨10.1016/j.ejmech.2020.112082⟩
International audience; We identified a new series of azole antifungal agents bearing a pyrrolotriazinone scaffold. These compounds exhibited a broad in vitro antifungal activity against pathogenic Candida spp. (fluconazole-susceptible and fluconazol
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c43babd6c0314939c9e45a6a3fd0ca5c
https://hal.archives-ouvertes.fr/hal-03412473
https://hal.archives-ouvertes.fr/hal-03412473
Autor:
Milan Dejmek, Michal Šála, Eliška Procházková, Ivana Mejdrová, Pavla Plačková, Gabriel Birkus, Martin Kögler, Radim Nencka, Evzen Boura, Hubert Hřebabecký, Adriana Baumlova, Gary Lee, Jan Weber, Dominika Chalupska, Helena Mertlíková-Kaiserová, Rémi Guillon, Dmytro Strunin
Publikováno v:
Journal of Medicinal Chemistry. 58:3767-3793
Phosphatidylinositol 4-kinase IIIβ is a cellular lipid kinase pivotal to pathogenesis of various RNA viruses. These viruses hijack the enzyme in order to modify the structure of intracellular membranes and use them for the construction of functional
Autor:
Rahila Rahimova, Isabelle Krimm, Suzanne Peyrottes, Preeti, Rémi Guillon, Corinne Lionne, Christian Périgaud, David Egron, Nushin Aghajari, Laurent Chaloin, Zsuzsanna Marton, Charles Dumontet, Lars Petter Jordheim
Publikováno v:
Journal of Medicinal Chemistry
Journal of Medicinal Chemistry, American Chemical Society, 2015, 58 (24), pp.9680-9696. 〈10.1021/acs.jmedchem.5b01616〉
Journal of Medicinal Chemistry, American Chemical Society, 2015, 58 (24), pp.9680-9696. ⟨10.1021/acs.jmedchem.5b01616⟩
Journal of Medicinal Chemistry, American Chemical Society, 2015, 58 (24), pp.9680-9696. 〈10.1021/acs.jmedchem.5b01616〉
Journal of Medicinal Chemistry, American Chemical Society, 2015, 58 (24), pp.9680-9696. ⟨10.1021/acs.jmedchem.5b01616⟩
International audience; We used a combined approach based on fragment-based drug design (FBDD) and in silico methods to design potential inhibitors of the cytosolic 5'-nucleotidase II (cN-II), which has been recognized as an important therapeutic tar
Autor:
Muriel Duflos, Marc Le Borgne, Rémi Guillon, Francis Giraud, Carine Picot, Florent Morio, Fabrice Pagniez, Damien Crepin, Patrice Le Pape, Cédric Logé
Publikováno v:
ChemMedChem. 6:816-825
As part of our studies focused on the design of 1-[((hetero)aryl- and piperidinylmethyl)amino]-2-phenyl-3-(1H-1,2,4-triazol-1-yl)propan-2-ols as antifungal agents, we report the development of new extended benzylamine derivatives substituted at the p
Autor:
Fabrice Pagniez, Carine Picot, Patrice Le Pape, Muriel Duflos, Rémi Guillon, Véronique Ferchaud-Roucher, Cédric Logé
Publikováno v:
Journal of Enzyme Inhibition and Medicinal Chemistry. 26:261-269
We extended our previous studies based on the design of 1-[(1H-indol-5-ylmethyl)amino]-2-phenyl-3-(1H-1,2,4-triazol-1-yl)propan-2-ols as antifungal agents toward the identification of new indol-3-ylmethylamino derivatives. The majority of these compo
Autor:
Carine Picot, Marc Le Borgne, Francis Giraud, Patrice Le Pape, Cédric Logé, Fabrice Pagniez, Rémi Guillon
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 19:5833-5836
We previously reported on the design and synthesis of 1-[((hetero)aryl- or piperidinylmethyl)amino]-2-phenyl-3-(1 H -1,2,4-triazol-1-yl)propan-2-ols showing various degrees of antifungal activity against Candida albicans and Aspergillus fumigatus str
Autor:
Marc Le Borgne, Rémi Guillon, Fabrice Pagniez, Patrice Le Pape, Francis Giraud, Carine Picot, Cédric Logé
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 19:301-304
Continuous efforts on the synthesis and structure–activity relationships (SARs) studies of modified 1-benzylamino-2-phenyl-3-(1 H -1,2,4-triazol-1-yl)propan-2-ols as antifungal agents, allowed identification of new 1-[(pyridinyl- and piperidinylmet
Autor:
Fabrice Pagniez, Alain Tonnerre, Patrice Le Pape, Thierry Besson, Carine Picot, Damien Hédou, Cédric Logé, Muriel Duflos, Rémi Guillon, Elizabeth Chosson
Publikováno v:
ACS Medicinal Chemistry Letters
ACS Medicinal Chemistry Letters, American Chemical Society, 2013, 4 (2), pp.288-292. ⟨10.1021/ml300429p⟩
ACS Medicinal Chemistry Letters, American Chemical Society, 2013, 4 (2), pp.288-292. ⟨10.1021/ml300429p⟩
Synthesis of a strict structural analogue of albaconazole in which the quinazolinone ring is fused by a thiazole moiety led to the discovery of a new triazole with broad-spectrum antifungal activity. Compound I exhibited high in vitro activity agains
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::63964d196e6b1ac81fd1d3b921fb6fe0
https://hal.archives-ouvertes.fr/hal-01015468
https://hal.archives-ouvertes.fr/hal-01015468
Autor:
Damien Hédou, Thierry Besson, Cédric Logé, Rémi Guillon, Charlotte Lecointe, Elizabeth Chosson
Publikováno v:
Tetrahedron
Tetrahedron, Elsevier, 2013, 69 (15), pp.3182-3191. ⟨10.1016/j.tet.2013.02.066⟩
Tetrahedron, Elsevier, 2013, 69 (15), pp.3182-3191. ⟨10.1016/j.tet.2013.02.066⟩
Synthesis of 9-oxo-8,9-dihydrothiazolo[5,4-f]quinazoline-2-carbonitrile (1) or 6-oxo-6,7-dihydrothiazolo[4,5-h]quinazoline-2-carbonitrile (2) was reinvestigated with the ambition of varying the position of the thiazole ring linked to the quinazolin-4
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b15afc2d90d06a75d30f896f0e0ae9db
https://hal.archives-ouvertes.fr/hal-01015586
https://hal.archives-ouvertes.fr/hal-01015586