Evaluation of PIG‐A mutated granulocytes and ex‐vivo binucleated micronucleated lymphocytes frequencies after breast cancer radiotherapy on in humans

Autor: Virginie Tassistro, D. Cowen, Thierry Orsière, Rémi Bonetto, Pierre Castel, Xavier Carcopino, Michelle Sergent, Stéphane Robert, Magalie Claeys-Bruno, Camille A Delecourt

Publikováno v: Environmental and Molecular Mutagenesis
Environmental and Molecular Mutagenesis, 2021, 62 (1), pp.18-28. ⟨10.1002/em.22413⟩
Environmental and Molecular Mutagenesis, Wiley-Blackwell, 2021, 62 (1), pp.18-28. ⟨10.1002/em.22413⟩

International audience; Although the PIG-A gene mutation frequency (MF) is considered a good proxy to evaluate the somatic MF in animals, evidence remains scarce in humans. In this study, a granulocyte PIG-A-mutant assay was evaluated in patients und

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::21584409b61f0fa7d320776532f4e61c
https://hal-amu.archives-ouvertes.fr/hal-03008376/document

Le gènePIG-A, nouveau marqueur de mutagenèse

Autor: Stéphane Robert, Thierry Orsière, D. Cowen, Pierre Castel, Rémi Bonetto, Xavier Carcopino

Publikováno v: médecine/sciences. 33:432-439

Gene mutations are not directly detected by current genotoxicity assays and most of them need a cell culture step. The whole blood PIG-A assay consists in the detection of the mutation frequency within the PIG-A sentinel gene by identification of gly

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::ab477812a44c57c6231205437dcf4363
https://doi.org/10.1051/medsci/20173304014

[The management of bone metastasis]

Autor: Rémi, Bonetto, Agnès, Tallet, Anthony, Mélot, Benoît, Calderon, Fabrice, Barlesi

Publikováno v: Bulletin du cancer. 104(6)

Bone metastasis are the most common cause of pain related to cancer, reducing patients' quality of life, and sometimes threatening their life-expectancy. Their management has to be pluridisciplinary, because of all the therapeutic options and the div

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::639756ec34b3a75d8abba890886bade2
https://pubmed.ncbi.nlm.nih.gov/28391985