Social and emotional alterations in mice lacking the short dystrophin-gene product, Dp71

Autor: Rubén Miranda, Léa Ceschi, Delphine Le Verger, Flora Nagapin, Jean-Marc Edeline, Rémi Chaussenot, Cyrille Vaillend

Publikováno v: Behavioral and Brain Functions, Vol 20, Iss 1, Pp 1-20 (2024)

Abstract Background The Duchenne and Becker muscular dystrophies (DMD, BMD) are neuromuscular disorders commonly associated with diverse cognitive and behavioral comorbidities. Genotype–phenotype studies suggest that severity and risk of central de

Externí odkaz: https://doaj.org/article/3fb862db70a24ebbb7e6d02af7c1d122

A multiscale analysis in CD38 −/− mice unveils major prefrontal cortex dysfunctions

Autor: José-Manuel Cancela, Oscar Bauer, Jean-Marc Edeline, Gabriel Benet, Antoine De Zelicourt, Catherine Sebrié, Cyrille Vaillend, Muriel Amar, Sabine De La Porte, Antony Galione, Philippe Fossier, Lora L Martucci, Anne Nosjean, Jacques Callebert, Rémi Chaussenot, Sylvie Granon, Jean-Marie Launay

Publikováno v: FASEB Journal
FASEB Journal, 2019, 54, pp.fj.201800489R. ⟨10.1096/fj.201800489R⟩
FASEB Journal, Federation of American Society of Experimental Biology, 2019, 54, pp.fj.201800489R. ⟨10.1096/fj.201800489R⟩
FASEB Journal, Federation of American Society of Experimental Biology, 2019, 33 (5), pp.5823-5835. ⟨10.1096/fj.201800489R⟩

International audience; Autism spectrum disorder (ASD) is characterized by early onset of behavioral and cognitive alterations. Low plasma levels of oxytocin (OT) have also been found in ASD patients; recently, a critical role for the enzyme CD38 in

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6302ec700c2754cce805314269bdb029
https://doi.org/10.1096/fj.201800489r

Dp71-Dystrophin Deficiency Alters Prefrontal Cortex Excitation-Inhibition Balance and Executive Functions

Autor: Muriel Amar, Rémi Chaussenot, Cyrille Vaillend, Philippe Fossier

Publikováno v: Molecular Neurobiology
Molecular Neurobiology, Humana Press, 2018, ⟨10.1007/s12035-018-1259-6⟩
Molecular Neurobiology, 2018, ⟨10.1007/s12035-018-1259-6⟩

International audience; In the Duchenne muscular dystrophy (DMD) syndrome, mutations affecting expression of Dp71, the main dystrophin isoform of the multipromoter dmd gene in brain, have been associated with intellectual disability and neuropsychiat

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fb1c46aa84b2bbec7755a668543150d9
https://pubmed.ncbi.nlm.nih.gov/30051354

Cerebellar synapse properties and cerebellum-dependent motor and non-motor performance in

Autor: Romain, Helleringer, Delphine, Le Verger, Xia, Li, Charlotte, Izabelle, Rémi, Chaussenot, Mehdi, Belmaati-Cherkaoui, Raoudha, Dammak, Paulette, Decottignies, Hervé, Daniel, Micaela, Galante, Cyrille, Vaillend

Publikováno v: Disease Models & Mechanisms

Recent emphasis has been placed on the role that cerebellar dysfunctions could have in the genesis of cognitive deficits in Duchenne muscular dystrophy (DMD). However, relevant genotype-phenotype analyses are missing to define whether cerebellar defe

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::c3b780c4f9ba90a0466041edc78b9273
https://pubmed.ncbi.nlm.nih.gov/29895670

Cognitive dysfunction in the dystrophin-deficient mouse model of Duchenne muscular dystrophy: A reappraisal from sensory to executive processes

Autor: Cyrille Vaillend, Serge Laroche, Rémi Chaussenot, Nicole El Massioui, Jean-Marc Edeline, Benoit Le Bec

Publikováno v: Neurobiology of Learning and Memory
Neurobiology of Learning and Memory, Elsevier, 2015, pp.S1074-7427. ⟨10.1016/j.nlm.2015.07.006⟩

International audience; Duchenne muscular dystrophy (DMD) is associated with language disabilities and deficits in learning and memory, leading to intellectual disability in a patient subpopulation. Recent studies suggest the presence of broader defi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c0895cd1116ee10a9368598dc13695e3
https://hal.archives-ouvertes.fr/hal-01179087