Zobrazeno 1 - 10
of 15
pro vyhledávání: '"Régis F. Moreau"'
Autor:
Liam A. Finlay, Régis F. Moreau, Jeffrey S. Monette, Kate Petersen Shay, Tory M. Hagen, Luis A. Gómez, Eric J. Smith, J. A. Butler, Alexander J. Michels, Kevin C. Dunn
Publikováno v:
Pharmacological Research. 63:23-29
Inflammation results in heightened mitochondrial ceramide levels, which cause electron transport chain dysfunction, elevates reactive oxygen species, and increases apoptosis. As mitochondria in aged hearts also display many of these characteristics,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fdce62a7b018068224d322d2824875c6
https://doi.org/10.1016/j.phrs.2010.09.007
https://doi.org/10.1016/j.phrs.2010.09.007
Publikováno v:
Biochimica et Biophysica Acta (BBA) - General Subjects. 1790:1149-1160
Alpha-lipoic acid (LA) has become a common ingredient in multivitamin formulas, anti-aging supplements, and even pet food. It is well-defined as a therapy for preventing diabetic polyneuropathies, and scavenges free radicals, chelates metals, and res
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0e76167bf5d4118cc7a13d993909c0f1
https://doi.org/10.1016/j.bbagen.2009.07.026
https://doi.org/10.1016/j.bbagen.2009.07.026
Publikováno v:
Antioxidants & Redox Signaling. 5:517-527
4-hydroxynonenal (HNE), a product of omega-6 polyunsaturated fatty acid peroxidation, impairs mitochondrial respiration in vitro by adducting the alpha-ketoglutarate dehydrogenase complex (KGDC) and inhibiting its activity. The present study seeks to
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e6da93470fc1c2c2458f58722a57a83b
https://doi.org/10.1089/152308603770310167
https://doi.org/10.1089/152308603770310167
Autor:
Eric J. Smith, J. A. Butler, Dove J. Keith, Tory M. Hagen, Luis A. Gómez, Régis F. Moreau, Liam A. Finlay
It is well established that lipid metabolism is controlled, in part, by circadian clocks. However, circadian clocks lose temporal precision with age and correlates with elevated incidence in dyslipidemia and metabolic syndrome in older adults. Becaus
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4bc5a2ec766c58a2dc40f10cf442279a
https://europepmc.org/articles/PMC4147855/
https://europepmc.org/articles/PMC4147855/
Publikováno v:
Journal of the World Aquaculture Society. 32:202-209
A 12-wk feeding trial was conducted in a flow-through system to determine whether juvenile golden shiner Notemigonus crysoleucas have a dietary requirement for ascorbic acid. Triplicate groups of 30 fish each weighing 0.44 g initially were fed semi-p
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ded64d25029bece33d3368cbe64058a3
https://doi.org/10.1111/j.1749-7345.2001.tb00372.x
https://doi.org/10.1111/j.1749-7345.2001.tb00372.x
Autor:
Jeffrey S. Monette, Alex J. Michels, Tory M. Hagen, Régis F. Moreau, Liam A. Finlay, Judy Ann Butler, Shay Kate Petersen, Balz Frei, Eric J. Smith
Publikováno v:
American journal of physiology. Regulatory, integrative and comparative physiology. 302(5)
To determine the effects of age and lipoic acid supplementation on hepatic gene expression, we fed young (3 mo) and old (24 mo) male Fischer 344 rats a diet with or without 0.2% (wt/wt) R-α-lipoic acid (LA) for 2 wk. Total RNA isolated from liver ti
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8d74b760bda9c10669cc52270999b5bf
https://pubmed.ncbi.nlm.nih.gov/22049228
https://pubmed.ncbi.nlm.nih.gov/22049228
Autor:
Brett A. Bemer, Tory M. Hagen, Luis A. Gómez, Jeffrey S. Monette, Alan W. Taylor, Régis F. Moreau
Mitochondrial sphingolipids play a diverse role in normal cardiac function and diseases, yet a precise quantification of cardiac mitochondrial sphingolipids has never been performed. Therefore, rat heart interfibrillary mitochondria (IFM) and subsarc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::26a206506a36a90a6a178b3df9c30a37
https://europepmc.org/articles/PMC2939858/
https://europepmc.org/articles/PMC2939858/
Elevated blood triacylglycerol (TG) is a significant contributing factor to the current epidemic of obesity-related health disorders, including type-2 diabetes, nonalcoholic fatty liver disease, and cardiovascular disease. The observation that mice l
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::861be8962a0b8ee33ca8bd184b988940
https://europepmc.org/articles/PMC2771166/
https://europepmc.org/articles/PMC2771166/
Publikováno v:
IUBMB life. 60(6)
The chemical reduction and oxidation (redox) properties of α-lipoic acid (LA) suggest that it may have potent antioxidant potential. A significant number of studies now show that LA and its reduced form, dihydrolipoic acid (DHLA), directly scavenge
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9e118c273aa515e1f4fcf7ffc05429e8
https://pubmed.ncbi.nlm.nih.gov/18409172
https://pubmed.ncbi.nlm.nih.gov/18409172
Publikováno v:
Biochemical and biophysical research communications. 325(1)
Mitochondrial uptake and beta-oxidation of long-chain fatty acids are markedly impaired in the aging rat heart. While these alterations would be expected to adversely affect overall pyridine nucleotides, NADH levels do not change significantly with a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7488f34e093478aa159f830a8fde06ed
https://pubmed.ncbi.nlm.nih.gov/15522199
https://pubmed.ncbi.nlm.nih.gov/15522199