Výsledky vyhledávání - "Régis Blaise"

Noncatalytic function of PI3Kγ drives smooth muscle cell proliferation after arterial damage

Autor: Régis Blaise, Damien Ramel, Natalia F. Smirnova, Emilio Hirsch, Alessandra Ghigo, Muriel Laffargue, Nicole Malet, Pierre Vincent, Stéphanie Gayral, Adrien Lupieri, Isabelle Limon, Marie-Kerguelen Sarthou

Publikováno v: Journal of Cell Science
Journal of Cell Science, Company of Biologists, 2020, pp.jcs.245969. ⟨10.1242/jcs.245969⟩
Journal of Cell Science, Company of Biologists, 2020, 133 (13), pp.jcs245969. ⟨10.1242/jcs.245969⟩
Journal of Cell Science, 2020, pp.jcs.245969. ⟨10.1242/jcs.245969⟩

International audience; Arterial remodeling in hypertension and intimal hyperplasia involves inflammation and disrupted flow, both of which contribute to smooth muscle cell dedifferentiation and proliferation. In this context, our previous results id

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9fd503acdf34174addc47312f4a6bfb5
https://hal.archives-ouvertes.fr/hal-02817436

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Novel short isoforms of adenylyl cyclase as negative regulators of cAMP production

Autor: Isabelle Limon, Laurent Duca, Benjamin Vallin, Pierre Vincent, Martine Glorian, Régis Blaise, Yohan Legueux-Cajgfinger, Nathalie Clément

Publikováno v: Biochimica et Biophysica Acta (BBA)-Molecular Cell Research
Biochimica et Biophysica Acta (BBA)-Molecular Cell Research, 2018, 1865 (9), pp.1326-1340. ⟨10.1016/j.bbamcr.2018.06.012⟩
Biochimica et Biophysica Acta-Molecular Cell Research
Biochimica et Biophysica Acta-Molecular Cell Research, Elsevier, 2018, 1865 (9), pp.1326-1340. ⟨10.1016/j.bbamcr.2018.06.012⟩

International audience; Here, we cloned a new family of four adenylyl cyclase (AC) splice variants from interleukin-1β (IL-1β)-transdifferentiated vascular smooth muscle cells (VSMCs) encoding short forms of AC8 that we have named "AC8E-H". Using b

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2d2050c61ee0492161acaf7677c9fb01
https://hal.sorbonne-universite.fr/hal-02372648

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Cerebrovascular β-amyloid deposition and associated microhemorrhages in a Tg2576 Alzheimer mouse model are reduced with a DHA-enriched diet

Autor: Isabelle Limon, Gilbert Bereziat, Claire Kanony-Truc, Véronique Mateo, Mégane Babiak, Nicolas Amalric, Justine Hur, Thierry Clerc, Régis Blaise

Publikováno v: FASEB journal : official publication of the Federation of American Societies for Experimental Biology. 32(9)

Cerebral amyloid angiopathy (CAA) is a major contributor to Alzheimer's disease (AD) pathogenesis. Like AD, CAA is often accompanied by marked inflammation, aggravating associated vasculopathies. No evidence-based prevention or treatment strategies a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a9d5872c1ca59e827ec2f77e65d5496e
https://pubmed.ncbi.nlm.nih.gov/29620941

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Novel subfamily of adenylyl cyclase 8 in vascular smooth muscle cells: Potential implication in pathological vascular remodelings

Autor: M. Babiak, Benjamin Vallin, Y. Legueux-Cajgfinger, Pierre Vincent, Régis Blaise, Isabelle Limon

Publikováno v: Archives of Cardiovascular Diseases Supplements. 11:195

Introduction The expansion of atherosclerotic lesions and post-angioplasty restenosis result mostly from a change in the phenotype of medial vascular smooth muscle cells (VSMC). We have provided evidence in vivo and in vitro that the de novo expressi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::83abc4bfe698aff8d915b13d4ddd364a
https://doi.org/10.1016/j.acvdsp.2019.02.031

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Protocol for Isolating the Mouse Circle of Willis

Autor: Régis Blaise, Justine Hur, Isabelle Limon

Publikováno v: Journal of visualized experiments : JoVE
Journal of visualized experiments : JoVE, 2016, 116, pp.e54352. ⟨10.3791/54352⟩
Journal of visualized experiments : JoVE, JoVE, 2016, pp.e54352. ⟨10.3791/54352⟩

International audience; The cerebral arterial circle (circulus arteriosus cerebri) or circle of Willis (CoW) is a circulatory anastomosis surrounding the optic chiasma and hypothalamus that supplies blood to the brain and surrounding structures. It h

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3f82275ff57e862fa47249bb67ba0536
https://hal.science/hal-01545424

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Wild-type amyloid beta 1-40 peptide induces vascular smooth muscle cell death independently from matrix metalloprotease activity

Autor: Véronique Mateo, Gilbert Bereziat, Martine Glorian, Isabelle Limon, Vladislav S. Golubkov, Régis Blaise, François Zaccarini, Clotilde Rouxel

Publikováno v: Aging Cell. 11:384-393

Cerebral amyloid angiopathy (CAA) is an important cause of intracerebral hemorrhages in the elderly, characterized by amyloid-β (Aβ) peptide accumulating in central nervous system blood vessels. Within the vessel walls, Aβ-peptide deposits [compos

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::f6e261bb9cf03a01f5187433cbfc0579
https://doi.org/10.1111/j.1474-9726.2012.00797.x

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The stellate vascular smooth muscle cell phenotype is induced by IL-1β via the secretion of PGE2 and subsequent cAMP-dependent protein kinase A activation

Autor: Olivier Meilhac, Karl Blirando, Natalia Gorodnaya, Régis Blaise, Isabelle Limon, Pierre Vincent, Clotilde Rouxel

Publikováno v: Biochimica et Biophysica Acta-Molecular Cell Research
Biochimica et Biophysica Acta-Molecular Cell Research, Elsevier, 2015, 1853 (12), pp.3235-3247. ⟨10.1016/j.bbamcr.2015.09.019⟩
Biochimica et Biophysica Acta-Molecular Cell Research, 2015, 1853 (12), pp.3235-3247. ⟨10.1016/j.bbamcr.2015.09.019⟩

International audience; Atherosclerosis development is associated with morphological changes to intimal cells, leading to a stellate cell phenotype. In this study, we aimed to determine whether and how key pro-atherogenic cytokines present in atheros

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e2d2fa2f32b5589b4a03a79f4930ba7d
https://hal.sorbonne-universite.fr/hal-01217160

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