Analysis of DNA methylation at birth and in childhood reveals changes associated with season of birth and latitude

Autor: Latha Kadalayil, Md. Zahangir Alam, Cory Haley White, Akram Ghantous, Esther Walton, Olena Gruzieva, Simon Kebede Merid, Ashish Kumar, Ritu P. Roy, Olivia Solomon, Karen Huen, Brenda Eskenazi, Peter Rzehak, Veit Grote, Jean-Paul Langhendries, Elvira Verduci, Natalia Ferre, Darek Gruszfeld, Lu Gao, Weihua Guan, Xuehuo Zeng, Enrique F. Schisterman, John F. Dou, Kelly M. Bakulski, Jason I. Feinberg, Munawar Hussain Soomro, Giancarlo Pesce, Nour Baiz, Elena Isaevska, Michelle Plusquin, Marina Vafeiadi, Theano Roumeliotaki, Sabine A. S. Langie, Arnout Standaert, Catherine Allard, Patrice Perron, Luigi Bouchard, Evelien R. van Meel, Janine F. Felix, Vincent W. V. Jaddoe, Paul D. Yousefi, Cecilia H. Ramlau-Hansen, Caroline L. Relton, Elmar W. Tobi, Anne P. Starling, Ivana V. Yang, Maria Llambrich, Gillian Santorelli, Johanna Lepeule, Lucas A. Salas, Mariona Bustamante, Susan L. Ewart, Hongmei Zhang, Wilfried Karmaus, Stefan Röder, Ana Claudia Zenclussen, Jianping Jin, Wenche Nystad, Christian M. Page, Maria Magnus, Dereje D. Jima, Cathrine Hoyo, Rachel L. Maguire, Tuomas Kvist, Darina Czamara, Katri Räikkönen, Tong Gong, Vilhelmina Ullemar, Sheryl L. Rifas-Shiman, Emily Oken, Catarina Almqvist, Robert Karlsson, Jari Lahti, Susan K. Murphy, Siri E. Håberg, Stephanie London, Gunda Herberth, Hasan Arshad, Jordi Sunyer, Regina Grazuleviciene, Dana Dabelea, Régine P. M. Steegers-Theunissen, Ellen A. Nohr, Thorkild I. A. Sørensen, Liesbeth Duijts, Marie-France Hivert, Vera Nelen, Maja Popovic, Manolis Kogevinas, Tim S. Nawrot, Zdenko Herceg, Isabella Annesi-Maesano, M. Daniele Fallin, Edwina Yeung, Carrie V. Breton, Berthold Koletzko, Nina Holland, Joseph L. Wiemels, Erik Melén, Gemma C. Sharp, Matt J. Silver, Faisal I. Rezwan, John W. Holloway

Publikováno v: Clinical Epigenetics, Vol 15, Iss 1, Pp 1-23 (2023)

Abstract Background Seasonal variations in environmental exposures at birth or during gestation are associated with numerous adult traits and health outcomes later in life. Whether DNA methylation (DNAm) plays a role in the molecular mechanisms under

Externí odkaz: https://doaj.org/article/d655547609c94f51b01a2521002c970a

Using the embryo-uterus statistical model to predict pregnancy chances by using cleavage stage morphokinetics and female age: two centre-specific prediction models and mutual validation

Autor: Eva S. van Marion, Esther B. Baart, Margarida Santos, Linette van Duijn, Evert J. P. van Santbrink, Régine P. M. Steegers-Theunissen, Joop S. E. Laven, Marinus J. C. Eijkemans

Publikováno v: Reproductive Biology and Endocrinology, Vol 21, Iss 1, Pp 1-12 (2023)

Abstract Background The predictive capability of time-lapse monitoring (TLM) selection algorithms is influenced by patient characteristics, type and quality of data included in the analysis and the used statistical methods. Previous studies excluded

Externí odkaz: https://doaj.org/article/ff9225e5a0f64685a6ebc6ad6ac8427d

Preferences of women with a vulnerable health status towards nudging for adequate pregnancy preparation as investment in health of future generations: a qualitative study

Autor: Sharissa M. Smith, Rianne M. J. J. van der Kleij, Babette Bais, Maartje H. N. Schermer, Hafez Ismaili M’hamdi, Régine P. M. Steegers-Theunissen

Publikováno v: BMC Pregnancy and Childbirth, Vol 22, Iss 1, Pp 1-12 (2022)

Abstract Background Women with a vulnerable health status, as determined by a low socioeconomic status and poor lifestyle behaviours, are at risk for adverse pregnancy outcomes. Offering tailored preconception lifestyle care can significantly help to

Externí odkaz: https://doaj.org/article/441c13315b174d648767c33cdd41c0a3

Corpus luteum number and the maternal renin-angiotensin-aldosterone system as determinants of utero-placental (vascular) development: the Rotterdam Periconceptional Cohort

Autor: Rosalieke E. Wiegel, Maud J. H. Karsten, Igna F. Reijnders, Lenie van Rossem, Sten P. Willemsen, Annemarie G. M. G. J. Mulders, Anton H. J. Koning, Eric A. P. Steegers, A. H. Jan Danser, Régine P. M. Steegers-Theunissen

Publikováno v: Reproductive Biology and Endocrinology, Vol 19, Iss 1, Pp 1-14 (2021)

Abstract Background Pregnancies with > 1 corpus luteum (CL) display a hyperdynamic circulation and an increased risk of small-for-gestational age deliveries. Among the factors released by the CL is prorenin, the inactive precursor of renin. Since the

Externí odkaz: https://doaj.org/article/c9fbac1508ef4a978924c2a1345033b7

The physiological effect of early pregnancy on a woman’s response to a submaximal cardiopulmonary exercise test

Autor: Rianne C. Bijl, Jérôme M. J. Cornette, Kim van derHam, Merle L. deZwart, Dinis Dos Reis Miranda, Régine P. M. Steegers‐Theunissen, Arie Franx, Jeroen Molinger, M. P. H. (Wendy) Koster

Publikováno v: Physiological Reports, Vol 8, Iss 21, Pp n/a-n/a (2020)

Abstract Given all its systemic adaptive requirements, pregnancy shares several features with physical exercise. In this pilot study, we aimed to assess the physiological response to submaximal cardiopulmonary exercise testing (CPET) in early pregnan

Externí odkaz: https://doaj.org/article/6e836d10107d45f8821d04b76e47aedf