Zobrazeno 1 - 10
of 79
pro vyhledávání: '"Régine Losson"'
Autor:
Katharina Leonards, Marwa Almosailleakh, Samantha Tauchmann, Frederik Otzen Bagger, Cécile Thirant, Sabine Juge, Thomas Bock, Hélène Méreau, Matheus F. Bezerra, Alexandar Tzankov, Robert Ivanek, Régine Losson, Antoine H. F. M. Peters, Thomas Mercher, Juerg Schwaller
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-15 (2020)
Loss of function mutations of NSD1 occur in blood cancers. Here, the authors report that NSD1 loss blocks erythroid differentiation which leads to an erythroleukemia-like disease in mice by impairing GATA1-induced target gene activation.
Externí odkaz:
https://doaj.org/article/23f6a9ca034c46419734966b67ed3c71
Autor:
David F. Vincent, Kai-Ping Yan, Isabelle Treilleux, Fabien Gay, Vanessa Arfi, Bastien Kaniewski, Julien C. Marie, Florian Lepinasse, Sylvie Martel, Sophie Goddard-Leon, Juan L. Iovanna, Pierre Dubus, Stéphane Garcia, Alain Puisieux, Ruth Rimokh, Nabeel Bardeesy, Jean-Yves Scoazec, Régine Losson, Laurent Bartholin
Publikováno v:
PLoS Genetics, Vol 5, Iss 8 (2009)
Externí odkaz:
https://doaj.org/article/ebf8a66d127f411d9ebcfcaac1edb941
Autor:
David F Vincent, Kai-Ping Yan, Isabelle Treilleux, Fabien Gay, Vanessa Arfi, Bastien Kaniewski, Julien C Marie, Florian Lepinasse, Sylvie Martel, Sophie Goddard-Leon, Juan L Iovanna, Pierre Dubus, Stéphane Garcia, Alain Puisieux, Ruth Rimokh, Nabeel Bardeesy, Jean-Yves Scoazec, Régine Losson, Laurent Bartholin
Publikováno v:
PLoS Genetics, Vol 5, Iss 7, p e1000575 (2009)
Inactivation of the Transforming Growth Factor Beta (TGFbeta) tumor suppressor pathway contributes to the progression of Pancreatic Ductal AdenoCarcinoma (PDAC) since it is inactivated in virtually all cases of this malignancy. Genetic lesions inacti
Externí odkaz:
https://doaj.org/article/cb97967f8e1a48baaf2fe656fecc984f
Autor:
Marwa Almosailleakh, Antoine H.F.M. Peters, Alexandar Tzankov, Thomas Bock, Sabine Juge, Matheus Filgueira Bezerra, Hélène Méreau, Frederik Otzen Bagger, Juerg Schwaller, Katharina Leonards, Samantha Tauchmann, Régine Losson, Thomas Mercher, Cécile Thirant, Robert Ivanek
Publikováno v:
Nature Communications
Nature Communications, Nature Publishing Group, 2020, 11 (1), pp.2807. ⟨10.1038/s41467-020-16179-8⟩
Nature Communications, Vol 11, Iss 1, Pp 1-15 (2020)
Nature Communications, 2020, 11 (1), pp.2807. ⟨10.1038/s41467-020-16179-8⟩
Nature Communications, Nature Publishing Group, 2020, 11 (1), pp.2807. ⟨10.1038/s41467-020-16179-8⟩
Nature Communications, Vol 11, Iss 1, Pp 1-15 (2020)
Nature Communications, 2020, 11 (1), pp.2807. ⟨10.1038/s41467-020-16179-8⟩
The nuclear receptor binding SET domain protein 1 (NSD1) is recurrently mutated in human cancers including acute leukemia. We show that NSD1 knockdown alters erythroid clonogenic growth of human CD34+ hematopoietic cells. Ablation of Nsd1 in the hema
Autor:
Matheus Filgueira Bezerra, Régine Losson, Juerg Schwaller, Alexandar Tzankov, Samantha Tauchmann, Robert Ivanek, Marwa Almosailleakh, Cécile Thirant, Sabine Juge, Frederik Otzen Bagger, Hélène Méreau, Antoine H.F.M. Peters, Katharina Leonards, Thomas Mercher
Publikováno v:
HemaSphere. 3:176-177
Autor:
Doulaye Dembélé, Régine Losson, Pierre Chambon, Johan Tisserand, Christelle Thibault, Konstantin Khetchoumian
Publikováno v:
Journal of Biological Chemistry. 286:33369-33379
Recent genetic studies in mice have established that the nuclear receptor coregulator Trim24/Tif1α suppresses hepatocarcinogenesis by inhibiting retinoic acid receptor α (Rara)-dependent transcription and cell proliferation. However, Rara targets r
Autor:
Florence Cammas, Régine Losson, Jing Wang, Frederick W. Alt, Adeline Page, Vincent Heyer, Beena Jeevan-Raj, Isabelle Robert, Bernardo Reina-San-Martin
Publikováno v:
The Journal of Experimental Medicine
A complex of KAP1 and HP1 is needed to tether AID to the H3K9me3-marked donor switch region during CSR.
Immunoglobulin class switch recombination (CSR) is initiated by double-stranded DNA breaks (DSBs) in switch regions triggered by activation-i
Immunoglobulin class switch recombination (CSR) is initiated by double-stranded DNA breaks (DSBs) in switch regions triggered by activation-i
Autor:
Pierre Chambon, Elena Enzo, Sirio Dupont, Konstantin Khetchoumian, Manuel Mark, Mariaceleste Aragona, Olivia Wendling, Leonardo Morsut, Stefano Piccolo, Kai-Ping Yan, Régine Losson, Sandra Soligo, Giorgio M. Bressan
Publikováno v:
Development. 137:2571-2578
The definition of embryonic potency and induction of specific cell fates are intimately linked to the tight control over TGFβ signaling. Although extracellular regulation of ligand availability has received considerable attention in recent years, su
Autor:
Régine Losson, Annick Harel-Bellan, Philippe Robin, Valentina Guasconi, Anna Polesskaya, Mouloud Souidi, Lauriane Fritsch, Ophelie Philipot, Slimane Ait-Si-Ali, Hakima Yahi
Publikováno v:
Journal of Biological Chemistry
Journal of Biological Chemistry, American Society for Biochemistry and Molecular Biology, 2008, 283 (35), pp.23692-700. ⟨10.1074/jbc.M802647200⟩
Journal of Biological Chemistry, 2008, 283 (35), pp.23692-700. ⟨10.1074/jbc.M802647200⟩
Journal of Biological Chemistry, American Society for Biochemistry and Molecular Biology, 2008, 283 (35), pp.23692-700. ⟨10.1074/jbc.M802647200⟩
Journal of Biological Chemistry, 2008, 283 (35), pp.23692-700. ⟨10.1074/jbc.M802647200⟩
International audience; Mechanisms of transcriptional repression are important during cell differentiation. Mammalian heterochromatin protein 1 isoforms HP1alpha, HP1beta, and HP1gamma play important roles in the regulation of chromatin structure and
Autor:
Régine Losson, Laetitia Fouillen, Florence Cammas, Delphine Quénet, Sarah Sanglier-Cianférani, Françoise Dantzer, Véronique Gasser
Publikováno v:
The FASEB Journal. 22:3853-3865
Recent advances reveal emerging unique functions of poly(ADP-ribose) polymerase-1 (Parp-1) and Parp-2 in heterochromatin integrity and cell differentiation. However, the chromatin-mediated molecular and cellular events involved remain elusive. Here w