Zobrazeno 1 - 10
of 15
pro vyhledávání: '"Régine Janel-Bintz"'
Processing closely spaced lesions during Nucleotide Excision Repair triggers mutagenesis in E. coli.
Publikováno v:
PLoS Genetics, Vol 13, Iss 7, p e1006881 (2017)
It is generally assumed that most point mutations are fixed when damage containing template DNA undergoes replication, either right at the fork or behind the fork during gap filling. Here we provide genetic evidence for a pathway, dependent on Nucleo
Externí odkaz:
https://doaj.org/article/33be63b4cdeb4c44bfa6ad512142559c
Autor:
Régine Janel-Bintz, Jérôme Wagner, Lajos Haracska, Marcia Chia Miao Mah-Becherel, Marc Bichara, Robert P Fuchs, Agnès M Cordonnier
Publikováno v:
PLoS ONE, Vol 7, Iss 4, p e36004 (2012)
Bypass of replication blocks by specialized DNA polymerases is crucial for cell survival but may promote mutagenesis and genome instability. To gain insight into mutagenic sub-pathways that coexist in mammalian cells, we examined N-2-acetylaminofluor
Externí odkaz:
https://doaj.org/article/d4f3b3c04d2e42d68a186569a2e4a961
Publikováno v:
Journal of Cell Science
Journal of Cell Science, Company of Biologists, 2021, ⟨10.1242/jcs.258637⟩
Journal of Cell Science, Company of Biologists, 2021, ⟨10.1242/jcs.258637⟩
DNA polymerase η (pol η) is specifically required for translesion DNA synthesis across ultraviolet radiation-induced DNA lesions. Recruitment of this error-prone DNA polymerase is tightly regulated during replication to avoid mutagenesis and pertur
Autor:
Philippe Frit, Philippe Hammann, Lajos Haracska, Agnès M. Cordonnier, Jérôme Wagner, Lauriane Kuhn, Johana Chicher, Régine Janel-Bintz
Publikováno v:
Proteomics
Proteomics, Wiley-VCH Verlag, 2020, 20 (3-4), pp.1900184. ⟨10.1002/pmic.201900184⟩
Proteomics, 2020, 20 (3-4), pp.1900184. ⟨10.1002/pmic.201900184⟩
Proteomics, Wiley-VCH Verlag, 2020, 20 (3-4), pp.1900184. ⟨10.1002/pmic.201900184⟩
Proteomics, 2020, 20 (3-4), pp.1900184. ⟨10.1002/pmic.201900184⟩
International audience; It is established that short inverted repeats trigger base substitution mutagenesis in human cells. However, how the replication machinery deals with structured DNA is unknown. It has been previously reported that in human cel
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cb3b3f159844809133971f4400abdfc3
https://hal.archives-ouvertes.fr/hal-02778571
https://hal.archives-ouvertes.fr/hal-02778571
Publikováno v:
PLoS Genetics, Vol 13, Iss 7, p e1006881 (2017)
PLoS Genetics
PLoS Genetics, Public Library of Science, 2017, 13 (7), pp.e1006881. ⟨10.1371/journal.pgen.1006881⟩
PLoS Genetics, 2017, 13 (7), pp.e1006881. ⟨10.1371/journal.pgen.1006881⟩
PLoS Genetics
PLoS Genetics, Public Library of Science, 2017, 13 (7), pp.e1006881. ⟨10.1371/journal.pgen.1006881⟩
PLoS Genetics, 2017, 13 (7), pp.e1006881. ⟨10.1371/journal.pgen.1006881⟩
It is generally assumed that most point mutations are fixed when damage containing template DNA undergoes replication, either right at the fork or behind the fork during gap filling. Here we provide genetic evidence for a pathway, dependent on Nucleo
Crosstalk between replicative and translesional DNA polymerases: PDIP38 interacts directly with Polη
Autor:
Agnès M. Cordonnier, Agnès Tissier, Stéphane Coulon, Esther Klaile, Patricia Kannouche, Robert P. P. Fuchs, Régine Janel-Bintz
Publikováno v:
DNA Repair
DNA Repair, Elsevier, 2010, 9 (8), pp.922-928. ⟨10.1016/j.dnarep.2010.04.010⟩
DNA Repair, Elsevier, 2010, 9 (8), pp.922-928. ⟨10.1016/j.dnarep.2010.04.010⟩
Replicative DNA polymerases duplicate genomes in a very efficient and accurate mode. However their progression can be blocked by DNA lesions since they are unable to accommodate bulky damaged bases in their active site. In response to replication blo
Publikováno v:
DNA Repair
DNA Repair, Elsevier, 2007, 6 (12), pp.1726-31. ⟨10.1016/j.dnarep.2007.06.003⟩
DNA Repair, Elsevier, 2007, 6 (12), pp.1726-31. ⟨10.1016/j.dnarep.2007.06.003⟩
The Rad6/Rad18-dependent monoubiquitination of PCNA plays a crucial role in regulating replication past DNA damage in eukaryotic cells. We show here that in human cell-free extracts, efficient PCNA monoubiquitination requires both the synthesis of re
Autor:
Agnès Tissier, Peter Burkovics, Marc Bichara, Agnès M. Cordonnier, Régine Janel-Bintz, Nadège Baldeck, Lajos Haracska, Robert P. P. Fuchs, Emmanuelle Despras, Bruno Chatton, Jérôme Wagner
Publikováno v:
Nucleic Acids Research
Nucleic Acids Research, Oxford University Press, 2015, 43 (4), pp.2116-2125. ⟨10.1093/nar/gkv076⟩
Nucleic Acids Research, Oxford University Press, 2015, 43 (4), pp.2116-2125. ⟨10.1093/nar/gkv076⟩
Switching between replicative and translesion synthesis (TLS) DNA polymerases are crucial events for the completion of genomic DNA synthesis when the replication machinery encounters lesions in the DNA template. In eukaryotes, the translesional DNA p
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ea88d704fbcd9bb7f2c79ddb31e50c4b
https://hal.archives-ouvertes.fr/hal-03300649
https://hal.archives-ouvertes.fr/hal-03300649
Publikováno v:
Journal of Molecular Biology. 352:501-509
Replication of genomes that contain blocking DNA lesions entails the transient replacement of the replicative DNA polymerase (Pol) by a polymerase specialized in lesion bypass. Here, we isolate and visualize at nucleotide resolution level, replicatio
Publikováno v:
Mutation Research/Genetic Toxicology and Environmental Mutagenesis. 493:127-137
The mutagenicity of 2-nitrofluorene (NF), N-hydroxyacetylaminofluorene (N-OH-AAF), and N-2-acetylaminofluorene (AAF) was measured in strains of Escherichia coli that contain a lacZ allele that reverts by -2 frameshift mutations from CG(5) to CG(4). M