Zobrazeno 1 - 5
of 5
pro vyhledávání: '"Récepteur tyrosine kinase ErbB2"'
Structural and functional investigation of the C-terminal intrinsically disordered fragment of ErbB2
Autor:
Pinet, Louise
ErbB2/HER2 est un récepteur tyrosine kinase de la famille d'EGFR (ErbB1) surexprimé dans plus de 20% des cancers du sein et associé à une forme particulièrement agressive de la maladie. Les récepteurs ErbBs sont actifs seulement sous forme de d
Externí odkaz:
http://www.theses.fr/2019SACLS375/document
Autor:
Pinet, Louise
Publikováno v:
Structural Biology [q-bio.BM]. Université Paris-Saclay, 2019. English. ⟨NNT : 2019SACLS375⟩
ErbB2/HER2 is a receptor tyrosine kinase of the EGFR (ErbB1) family overexpressed in 20% of breast cancers and associated to a particularly aggressive form of the disease. ErbB receptors are only active upon dimerization that enables phosphorylation
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=dedup_wf_001::db2ae1c4ce0a928b307a068baf2c4a44
https://theses.hal.science/tel-02391272
https://theses.hal.science/tel-02391272
Publikováno v:
Médecine Sciences; dec2018, Vol. 34 Issue 12, p1079-1086, 8p
Autor:
Bo, Chengyuan
Gene amplification and elevated expression of ErbB2 receptor tyrosine kinase has been implicated in the development and progression of human breast cancer, and correlates to poor clinical outcomes. Transgenic mouse models provide a good tool to study
Autor:
Dillon, Rachelle Lee
Overexpression of the ErbB2 receptor tyrosine kinase is observed in 20-30% of human breast cancers and correlates with poor prognostic outcome. To identify novel drug targets to treat ErbB2 positive breast cancer, a better understanding of both the p