CAMAP: Artificial neural networks unveil the role of codon arrangement in modulating MHC-I peptides presentation

Autor: Tariq Daouda, Maude Dumont-Lagacé, Albert Feghaly, Yahya Benslimane, Rébecca Panes, Mathieu Courcelles, Mohamed Benhammadi, Lea Harrington, Pierre Thibault, François Major, Yoshua Bengio, Étienne Gagnon, Sébastien Lemieux, Claude Perreault

Publikováno v: PLoS Computational Biology, Vol 17, Iss 10 (2021)

MHC-I associated peptides (MAPs) play a central role in the elimination of virus-infected and neoplastic cells by CD8 T cells. However, accurately predicting the MAP repertoire remains difficult, because only a fraction of the transcriptome generates

Externí odkaz: https://doaj.org/article/cbd385c9465f4eb1bec7127d68136b08

TMEM16F mediates bystander TCR-CD3 membrane dissociation at the immunological synapse and potentiates T cell activation

Autor: Audrey Connolly, Margaux Tual, Etienne Gagnon, Rébecca Panes, Angelique Bellemare-Pelletier, Raphaël Lafortune

Publikováno v: Science Signaling. 14

Electrostatic interactions regulate many aspects of T cell receptor (TCR) activity, including enabling the dynamic binding of the TCR-associated CD3e and CD3ζ chains to anionic lipids in the plasma membrane to prevent spontaneous phosphorylation. Su

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::eb609e67ae045d2b5991b7fe220801b8
https://doi.org/10.1126/scisignal.abb5146

Critical role for TRIM28 and HP1β/γ in the epigenetic control of T cell metabolic reprograming and effector differentiation

Autor: Marianne Burbage, Pablo J. Sáez, Deborah Lefevre, Thomas Hoyler, Amal Zine El Aabidine, Rébecca Panes, Guadalupe Suarez, Christel Goudot, Sebastian Amigorena, Jean-Marie Carpier, Mengliang Ye, Fanny Aprahamian, Claire Hivroz, Florence Cammas, Olivier Joffre, Véronique Adoue, Elina Zueva, Jean-Christophe Andrau, Angelique Bellemare-Pelletier, Sylvère Durand, Leonel Joannas, Etienne Gagnon, Maqbool Muhammad Ahmad, Guido Kroemer, Cyril Esnault, Ulf Gehrmann, Sandrine Heurtebise-Chrétien, Nina Burgdorf

Publikováno v: Proceedings of the National Academy of Sciences of the United States of America
Proceedings of the National Academy of Sciences of the United States of America, National Academy of Sciences, 2019, 116 (51), pp.25839-25849. ⟨10.1073/pnas.1901639116⟩
Proceedings of the National Academy of Sciences of the United States of America, 2019, 116 (51), pp.25839-25849. ⟨10.1073/pnas.1901639116⟩

Significance CD4 T cells are major regulators of immune responses against both self and pathogens. Understanding pathways that govern CD4 T cell differentiation and regulation are thus key for the discovery of new immunoregulatory drug targets. Here,

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dbdc87a7d673a9a3997e6fdd23ac6a75
https://hal.archives-ouvertes.fr/hal-02369616/document