Zobrazeno 1 - 10
of 620
pro vyhledávání: '"R, van Driel"'
Autor:
Markus Fleischmann, Andrew G. Jarnicki, Andrew S. Brown, Chao Yang, Gary P. Anderson, Natalio Garbi, Elizabeth L. Hartland, Ian R. van Driel, Garrett Z. Ng
Publikováno v:
American Journal of Physiology-Lung Cellular and Molecular Physiology. 324:L373-L384
Legionella pneumophila is the main etiological agent of Legionnaires’ disease, a severe bacterial pneumonia. L. pneumophila is initially engulfed by alveolar macrophages (AMs) and subvert normal cellular functions to establish a replicative vacuole
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a8de7f760fc8b9203ca21016e6334ce2
https://doi.org/10.1152/ajplung.00268.2022
https://doi.org/10.1152/ajplung.00268.2022
Publikováno v:
Frontiers in Immunology, Vol 10 (2019)
We have examined the influence of depleting plasmacytoid dendritic cells (pDC) in mice on the immune response to the gut pathogen Citrobacter rodentium, an organism that is a model for human attaching effacing pathogens such as enterohaemorraghic E.
Externí odkaz:
https://doaj.org/article/3ca5d19199d54bfb8690356220d6d9d6
Autor:
Andrew S Brown, Chao Yang, Ka Yee Fung, Annabell Bachem, Dorothée Bourges, Sammy Bedoui, Elizabeth L Hartland, Ian R van Driel
Publikováno v:
PLoS Pathogens, Vol 12, Iss 6, p e1005691 (2016)
Legionella pneumophila is the causative agent of Legionnaires' disease, a potentially fatal lung infection. Alveolar macrophages support intracellular replication of L. pneumophila, however the contributions of other immune cell types to bacterial ki
Externí odkaz:
https://doaj.org/article/462e61b3197d46818e1ddcf884236d0b
Publikováno v:
PLoS ONE, Vol 9, Iss 8, p e104753 (2014)
Breast cancer resistance protein (ABCG2), a member of the ATP-binding cassette transporters has been identified as a major determinant of multidrug resistance (MDR) in cancer cells, but ABC transporter inhibition has limited therapeutic value in vivo
Externí odkaz:
https://doaj.org/article/7d26a34a9dd24389942775854bcab943
Publikováno v:
Biochemical Society Transactions
Interferon (IFN)-induced guanosine triphosphate hydrolysing enzymes (GTPases) have been identified as cornerstones of IFN-mediated cell-autonomous defence. Upon IFN stimulation, these GTPases are highly expressed in various host cells, where they orc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::79e72a3e754e0c3ed9202495e586738f
https://pubmed.ncbi.nlm.nih.gov/34003245
https://pubmed.ncbi.nlm.nih.gov/34003245
Autor:
Georgina L. Pollock, Joshua P M Newson, Cristina Giogha, Tania Wong Fok Lung, Jaclyn S. Pearson, Nichollas E. Scott, Ian R. van Driel, Garrett Z. Ng, Jiyao Gan, Rachelia R. Wibawa, Elizabeth L. Hartland
Publikováno v:
Frontiers in Cellular and Infection Microbiology, Vol 10 (2020)
Frontiers in Cellular and Infection Microbiology, 10
Frontiers in Cellular and Infection Microbiology, 10
During infection, Salmonella species inject multiple type III secretion system (T3SS) effector proteins into host cells that mediate invasion and subsequent intracellular replication. At early stages of infection, Salmonella exploits key regulators o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::25694d2ebc34b62be95a546bc02c89a6
https://www.frontiersin.org/article/10.3389/fcimb.2020.00419/full
https://www.frontiersin.org/article/10.3389/fcimb.2020.00419/full
Publikováno v:
Frontiers in Cellular and Infection Microbiology, Vol 2 (2011)
Legionella pneumophila is an intracellular pathogen that replicates within alveolar macrophages. Through its ability to activate multiple host innate immune components, L. pneumophila has emerged as a useful tool to dissect inflammatory signalling pa
Externí odkaz:
https://doaj.org/article/7ab2aa3fa9524c07b722976706acd92a
Autor:
Eric Tu, Desmond K Y Ang, Thea V Hogan, Simon Read, Cheryl P Z Chia, Paul A Gleeson, Ian R van Driel
Publikováno v:
PLoS ONE, Vol 6, Iss 11, p e27153 (2011)
Autoimmune gastritis results from the breakdown of T cell tolerance to the gastric H(+)/K(+) ATPase. The gastric H(+)/K(+) ATPase is responsible for the acidification of gastric juice and consists of an α subunit (H/Kα) and a β subunit (H/Kβ). He
Externí odkaz:
https://doaj.org/article/0b44e4837783435d8d40abcf6bc5c378
Publikováno v:
Journal of Leukocyte Biology. 101:875-886
Legionella pneumophila causes Legionnaires’ disease, a severe and potentially fatal bacterial pneumonia in immunocompromised individuals. Despite the understanding that a robust inflammatory response is important for control of L. pneumophila infec
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::963d8168f3b9b8676781fe1a45073de7
https://doi.org/10.1189/jlb.4mr0816-340r
https://doi.org/10.1189/jlb.4mr0816-340r
Autor:
Markus Fleischmann, Nigel W. Bunnett, Paulina Kasperkiewicz, Luigi Aurelio, Celine Morissette, Marcin Drag, Daniel P. Poole, Bethany M. Anderson, Ian R. van Driel, Laura E. Edgington-Mitchell, Garrett Z. Ng, Stephen Vanner, Brian L. Schmidt
Publikováno v:
Scientific Reports, Vol 9, Iss 1, Pp 1-12 (2019)
Scientific Reports
Scientific Reports
Neutrophil elastase is a serine protease that has been implicated in the pathogenesis of inflammatory bowel disease. Due to post-translational control of its activation and high expression of its inhibitors in the gut, measurements of total expressio
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a92d8bd66edbe40ca61137e9119fc073
https://doi.org/10.1038/s41598-019-49840-4
https://doi.org/10.1038/s41598-019-49840-4