Zobrazeno 1 - 10
of 21
pro vyhledávání: '"R, de Candia"'
Autor:
Luke M. Evans, Michael E. Goddard, Rasool Tahmasbi, Sayantan Das, Douglas W. Bjelland, Gonçalo R. Abecasis, Scott I. Vrieze, Jian Yang, Matthew C. Keller, Teresa R de Candia, Peter M. Visscher, Benjamin M. Neale, Steven Gazal
Publikováno v:
Nature genetics
Multiple methods have been developed to estimate narrow-sense heritability, h2, using single nucleotide polymorphisms (SNPs) in unrelated individuals. However, a comprehensive evaluation of these methods has not yet been performed, leading to confusi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a5f5e0c9ce0187d3a4f5a0cb74c6b875
https://doi.org/10.1038/s41588-018-0108-x
https://doi.org/10.1038/s41588-018-0108-x
Autor:
Arden Moscati, Ayman H. Fanous, Kenneth S. Kendler, Anna R. Docherty, Brion S. Maher, Francis A. O'Neill, Dawn L. Thiselton, Dermot Walsh, Brandon Wormley, Silviu Alin Bacanu, Alexis C. Edwards, Brien P. Riley, Tim B. Bigdeli, Donghyung Lee, Teresa R de Candia
Publikováno v:
Schizophrenia Bulletin. 42:279-287
Background Evidence suggests that genetic factors may influence both schizophrenia (Scz) and its clinical presentation. In recent years, genome-wide association studies (GWAS) have demonstrated considerable success in identifying risk loci. Detection
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::923683536007b1044cd127a07434d647
https://doi.org/10.1093/schbul/sbv119
https://doi.org/10.1093/schbul/sbv119
Publikováno v:
Current Opinion in Behavioral Sciences. 2:73-80
We describe the scientific enterprise at the intersection of evolutionary psychology and behavioral genetics — a field that could be termed Evolutionary Behavioral Genetics — and how modern genetic data is revolutionizing our ability to test ques
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d38f07e7077350179273f3e30bd197f3
https://doi.org/10.1016/j.cobeha.2014.09.005
https://doi.org/10.1016/j.cobeha.2014.09.005
Autor:
Matthew C. Keller, Teresa R de Candia, Luke M. Evans, Sayantan Das, Gonçalo R. Abecasis, Michael E. Goddard, Douglas W. Bjelland, Benjamin M. Neale, Scott I. Vrieze, Peter M. Visscher, Jian Yang, Rasool Tahmasbi
Heritability, h2, is a foundational concept in genetics, critical to understanding the genetic basis of complex traits. Recently-developed methods that estimate heritability from genotyped SNPs, h2SNP, explain substantially more genetic variance than
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dbe25115765809a68e524b73e5cfe55a
Autor:
Alexis C, Edwards, Tim B, Bigdeli, Anna R, Docherty, Silviu, Bacanu, Donghyung, Lee, Teresa R, de Candia, Arden, Moscati, Dawn L, Thiselton, Brion S, Maher, Brandon K, Wormley, Dermot, Walsh, Francis A, O'Neill, Kenneth S, Kendler, Brien P, Riley, Dragan M, Svrakic
Publikováno v:
Schizophrenia bulletin. 42(2)
Background: Evidence suggests that genetic factors may influence both schizophrenia (Scz) and its clinical presentation. In recent years, genome-wide association studies (GWAS) have demonstrated considerable success in identifying risk loci. Detectio
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::1065177930b70b8b67ad65257dca0ac5
https://pubmed.ncbi.nlm.nih.gov/26316594
https://pubmed.ncbi.nlm.nih.gov/26316594
Autor:
Matthew C. Keller, Jian Yang, Teresa R de Candia, Matt Jones, Lindon J. Eaves, Michael E. Goddard, Rasool Tahmasbi, David M. Evans, Luke M. Evans, Peter M. Visscher
Publikováno v:
European Neuropsychopharmacology. 29:S788-S789
Background Mates are similar to one another across a large number of traits, including liabilities underlying psychiatric disorders. It has long been known that when such phenotypic similarity implies genetic similarity (hereafter, assortative mating
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d28e54da4e57eeb2affe69b3b480e27d
https://doi.org/10.1016/j.euroneuro.2017.08.016
https://doi.org/10.1016/j.euroneuro.2017.08.016
Autor:
Noah Zaitlen, Jian Yang, Po-Ru Loh, Matthew C. Keller, Alkes L. Price, Mark J. Daly, Teresa R de Candia, Hilary K. Finucane, Alexander Gusev, Stephan Ripke, Bogdan Pasaniuc, Eli A. Stahl, Bjarni J. Vilhjálmsson, Shaun Purcell, Sang Hong Lee, Nick Patterson, Benjamin M. Neale, Gaurav Bhatia
Genome-wide significant associations generally explain only a small proportion of the narrow-sense heritability of complex disease (h2). While considerably more heritability is explained by all genotyped SNPs (hg2), for most traits, much heritability
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a8ca2cee986739c377d9d1737d94b5c7
https://doi.org/10.1101/048181
https://doi.org/10.1101/048181
Autor:
Alkes L. Price, Noah Zaitlen, Gaurav Bhatia, Eli A. Stahl, Sang Hong Lee, Po-Ru Loh, Stephan Ripke, Benjamin M. Neale, Kenneth S. Kendler, Mark J. Daly, Bogdan Pasaniuc, Shaun Purcell, Matthew C. Keller, Naomi R. Wray, Teresa R de Candia, Jian Yang, Michael Conlon O'Donovan, Alexander Gusev, Bjarni J. Vilhjálmsson
While genome-wide significant associations generally explain only a small proportion of the narrow-sense heritability of complex disease (h2), recent work has shown that more heritability is explained by all genotyped SNPs (hg2). However, much of the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7fc4d741c18da2adc2657d80fecd64ab
https://doi.org/10.1101/022418
https://doi.org/10.1101/022418
Autor:
Po-Ru Loh, Gaurav Bhatia, Alexander Gusev, Hilary K Finucane, Brendan K Bulik-Sullivan, Samuela J Pollack, Schizophrenia Working Group Psychiatric Genomics Consortium, Teresa R de Candia, Sang Hong Lee, Naomi R Wray, Kenneth S Kendler, Michael C O'Donovan, Benjamin M Neale, Nick Patterson, Alkes L Price
Heritability analyses of GWAS cohorts have yielded important insights into complex disease architecture, and increasing sample sizes hold the promise of further discoveries. Here, we analyze the genetic architecture of schizophrenia in 49,806 samples
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4ea58352b3b4fda215d6752ea1b7cf5c
Autor:
Matthew C. Keller, Danielle Posthuma, Douglas F. Levinson, Teresa R de Candia, Shaun Purcell, Bryan J. Mowry, Jian Yang, Naomi R. Wray, Michael E. Goddard, S. Hong Lee, Michael Conlon O'Donovan, Pablo V. Gejman, Brian L. Browning, Peter M. Visscher, John K. Hewitt
Publikováno v:
De Candia, T R, Lee, S H, Yang, J, Browning, B L, Gejman, P V, Levinson, D F, Mowry, B J, Hewitt, J K, Goddard, M E, O'Donovan, M C, Purcell, S M, Posthuma, D, Visscher, P M, Wray, N R & Keller, M C 2013, ' Additive genetic variation in schizophrenia risk is shared by populations of African and European descent ', American Journal of Human Genetics, vol. 93, no. 3, pp. 463-470 . https://doi.org/10.1016/j.ajhg.2013.07.007
American Journal of Human Genetics, 93(3), 463-470. Cell Press
American Journal of Human Genetics, 93(3), 463-470. Cell Press
To investigate the extent to which the proportion of schizophrenia's additive genetic variation tagged by SNPs is shared by populations of European and African descent, we analyzed the largest combined African descent (AD [n = 2,142]) and European de
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d166d1d757d61abd1d9cf5adb8ca0093
https://research.vu.nl/en/publications/806070af-45c7-4409-a39b-51645244281e
https://research.vu.nl/en/publications/806070af-45c7-4409-a39b-51645244281e