Zobrazeno 1 - 10
of 1 249
pro vyhledávání: '"R, Wills"'
Publikováno v:
iScience, Vol 27, Iss 2, Pp 108977- (2024)
Summary: The Michaelis-Menten model requires its reaction velocities to come from a preparation of homogeneous enzymes, with identical or near-identical catalytic activities. However, this condition is not always met. We introduce a kinetic model tha
Externí odkaz:
https://doaj.org/article/3e4be62b203843e3ab15036bb1390c16
Autor:
Isabella A.T.M. Ferreira, Colin Y.C. Lee, William S. Foster, Adam Abdullahi, Lisa M. Dratva, Zewen Kelvin Tuong, Benjamin J. Stewart, John R. Ferdinand, Stephane M. Guillaume, Martin O.P. Potts, Marianne Perera, Benjamin A. Krishna, Ana Peñalver, Mia Cabantous, Steven A. Kemp, Lourdes Ceron-Gutierrez, Soraya Ebrahimi, Paul Lyons, Kenneth G.C. Smith, John Bradley, Dami A. Collier, Laura E. McCoy, Agatha van der Klaauw, James E.D. Thaventhiran, I. Sadaf Farooqi, Sarah A. Teichmann, Paul A. MacAry, Rainer Doffinger, Mark R. Wills, Michelle A. Linterman, Menna R. Clatworthy, Ravindra K. Gupta
Publikováno v:
Cell Reports, Vol 42, Iss 8, Pp 112991- (2023)
Summary: Suboptimal responses to a primary vaccination course have been reported in the elderly, but there is little information regarding the impact of age on responses to booster third doses. Here, we show that individuals 70 years or older (median
Externí odkaz:
https://doaj.org/article/ae089416071a4557966b754f87892413
Autor:
Martin Potts, Alice Fletcher-Etherington, Katie Nightingale, Federica Mescia, Laura Bergamaschi, Fernando J. Calero-Nieto, Robin Antrobus, James Williamson, Harriet Parsons, Edward L. Huttlin, Nathalie Kingston, Berthold Göttgens, John R. Bradley, Paul J. Lehner, Nicholas J. Matheson, Kenneth G.C. Smith, Mark R. Wills, Paul A. Lyons, Michael P. Weekes
Publikováno v:
Cell Reports, Vol 42, Iss 6, Pp 112613- (2023)
Summary: Certain serum proteins, including C-reactive protein (CRP) and D-dimer, have prognostic value in patients with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Nonetheless, these factors are non-specific, providing limited mecha
Externí odkaz:
https://doaj.org/article/c7326025d3cb4f20b0a4a053867e6734
Autor:
Peter R. Wills
Publikováno v:
Entropy, Vol 25, Iss 9, p 1281 (2023)
The origin of genetic coding is characterised as an event of cosmic significance in which quantum mechanical causation was transcended by constructive computation. Computational causation entered the physico-chemical processes of the pre-biotic world
Externí odkaz:
https://doaj.org/article/0272974c042f4760bad32def66a859ff
Autor:
Emma L. Davies, Mahlaqua Noor, Eleanor Y. Lim, Charlotte J. Houldcroft, Georgina Okecha, Claire Atkinson, Matthew B. Reeves, Sarah E. Jackson, Mark R. Wills
Publikováno v:
Frontiers in Immunology, Vol 13 (2022)
Human cytomegalovirus (HCMV) infection and periodic reactivation is, generally, well controlled by adaptative immune responses in the healthy. In older people, overt HCMV disease is rarely seen despite the association of HCMV with increased risk of m
Externí odkaz:
https://doaj.org/article/1bf0e06452cf4928b7da81b151877001
Autor:
Benjamin A. Krishna, Eleanor Y. Lim, Lenette Mactavous, Paul A. Lyons, Rainer Doffinger, John R. Bradley, Kenneth G.C. Smith, John Sinclair, Nicholas J. Matheson, Paul J. Lehner, Mark R. Wills, Nyaradzai Sithole
Publikováno v:
EBioMedicine, Vol 81, Iss , Pp 104129- (2022)
Summary: Background: There is currently no consensus on the diagnosis, definition, symptoms, or duration of COVID-19 illness. The diagnostic complexity of Long COVID is compounded in many patients who were or might have been infected with SARS-CoV-2
Externí odkaz:
https://doaj.org/article/b804555307e642b3be053fb996e2b97f
Autor:
Sarah E. Jackson, George X. Sedikides, Veronika Romashova, Georgina Okecha, Ester B. M. Remmerswaal, Frederike J. Bemelman, John H. Sinclair, Mark R. Wills
Publikováno v:
Pathogens, Vol 11, Iss 12, p 1530 (2022)
HCMV-specific CD8+ T-cells are potent anti-viral effector cells in HCMV infected individuals, but evidence from other viral infections suggests that CD8+ T-cells can also produce the immunomodulatory cytokine IL-10. In this work we show that there ar
Externí odkaz:
https://doaj.org/article/97e1dc3c06b840ab84bb43b3089f9a30
Publikováno v:
New Zealand Geographer. 79:27-32
Autor:
Sarah E. Jackson, Kevin C. Chen, Ian J. Groves, George X. Sedikides, Amar Gandhi, Charlotte J. Houldcroft, Emma L. Poole, Inmaculada Montanuy, Gavin M. Mason, Georgina Okecha, Matthew B. Reeves, John H. Sinclair, Mark R. Wills
Publikováno v:
Frontiers in Immunology, Vol 12 (2021)
Human cytomegalovirus (HCMV) infection is not cleared by the initial immune response but persists for the lifetime of the host, in part due to its ability to establish a latent infection in cells of the myeloid lineage. HCMV has been shown to manipul
Externí odkaz:
https://doaj.org/article/e97d64960ba34f25aabbe32eb204d4f4
Autor:
Lior Soday, Martin Potts, Leah M. Hunter, Benjamin J. Ravenhill, Jack W. Houghton, James C. Williamson, Robin Antrobus, Mark R. Wills, Nicholas J. Matheson, Michael P. Weekes
Publikováno v:
Frontiers in Immunology, Vol 12 (2021)
The cellular response to interferon (IFN) is essential for antiviral immunity, IFN-based therapy and IFN-related disease. The plasma membrane (PM) provides a critical interface between the cell and its environment, and is the initial portal of entry
Externí odkaz:
https://doaj.org/article/fd64e47b9b4b4f72b97a7e62b277b2d8