Zobrazeno 1 - 10
of 2 878
pro vyhledávání: '"R, Viswanathan"'
Autor:
Talal El Zarif, Karl Semaan, Marc Eid, Ji-Heui Seo, Simon Garinet, Matthew P. Davidsohn, Pranshu Sahgal, Brad Fortunato, John Canniff, Amin H. Nassar, Sarah Abou Alaiwi, Ziad Bakouny, Gitanjali Lakshminarayanan, Hunter Savignano, Kevin Lyons, Sayed Matar, Atef Ali, Eddy Saad, Renee Maria Saliby, Paulo Cordeiro, Ziwei Zhang, Nourhan El Ahmar, Yasmin Nabil Laimon, Chris Labaki, Valisha Shah, Dory Freeman, Jillian O’Toole, Gwo-Shu Mary Lee, Justin Hwang, Mark Pomerantz, Sabina Signoretti, Eliezer M. Van Allen, Wanling Xie, Jacob E. Berchuck, Srinivas R. Viswanathan, David A. Braun, Toni K. Choueiri, Matthew L. Freedman, Sylvan C. Baca
Publikováno v:
Cell Reports, Vol 43, Iss 6, Pp 114350- (2024)
Summary: Renal cell carcinoma with sarcomatoid differentiation (sRCC) is associated with poor survival and a heightened response to immune checkpoint inhibitors (ICIs). Two major barriers to improving outcomes for sRCC are the limited understanding o
Externí odkaz:
https://doaj.org/article/a9e18e74ab10487c9c8418746dfe9c2a
Publikováno v:
Biomolecules, Vol 14, Iss 8, p 983 (2024)
Accurate computational prediction of B-cell epitopes can greatly enhance biomedical research and rapidly advance efforts to develop therapeutics, monoclonal antibodies, vaccines, and immunodiagnostic reagents. Previous research efforts have primarily
Externí odkaz:
https://doaj.org/article/44b6434cdacb46e3bed2baa974bfcfbd
Publikováno v:
Journal of Sugarcane Research, Vol 12, Iss 2 (2024)
Stalk rot is one of the important diseases of sugarcane - caused by Phaeocytostroma sacchari. Survey and monitoring was done during 2020-2022 to assess the status of stalk rot in the sugarcane germplasm and molecular identification of the associated
Externí odkaz:
https://doaj.org/article/a51e5f39ebd34a8596206a7bdf57fadd
Publikováno v:
Journal of Sugarcane Research, Vol 12, Iss 2 (2024)
Sugarcane rust incited by Puccinia melanocephala (brown rust) and P. kuehnii (orange rust) becomes very severe under warm,moist climatic conditions. Though there were methods to screen rust resistance under artificial conditions where rust is prevale
Externí odkaz:
https://doaj.org/article/afa0d8f1a9f04a6f968581222383ddf7
Publikováno v:
Journal of Sugarcane Research, Vol 11, Iss 2, Pp 205-211 (2023)
Yellow leaf disease (YLD) is one of the important viral diseases in sugarcane. It is caused by Sugarcane yellow leaf virus (ScYLV), a positive sense single stranded RNA virus primarily transmits through infected setts and secondarily transmits throug
Externí odkaz:
https://doaj.org/article/8f48366e516c41188b6ffcfd6fb97af5
Publikováno v:
Cell Reports, Vol 42, Iss 8, Pp 112978- (2023)
Summary: The success of precision oncology—which aims to match the right therapies to the right patients based on molecular status—is predicated on a robust pipeline of molecular targets against which therapies can be developed. Recent advances i
Externí odkaz:
https://doaj.org/article/e2a9b918547f404dbffa2454a9fc8ff9
Publikováno v:
BMC Bioinformatics, Vol 23, Iss 1, Pp 1-16 (2022)
Abstract Background Identifying protein interfaces can inform how proteins interact with their binding partners, uncover the regulatory mechanisms that control biological functions and guide the development of novel therapeutic agents. A variety of c
Externí odkaz:
https://doaj.org/article/1d3d9e5f3f35417698065a794f40f418
Autor:
Nicola Alesi, Elie W. Akl, Damir Khabibullin, Heng-Jia Liu, Anna S. Nidhiry, Emma R. Garner, Harilaos Filippakis, Hilaire C. Lam, Wei Shi, Srinivas R. Viswanathan, Manrico Morroni, Shawn M. Ferguson, Elizabeth P. Henske
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-12 (2021)
Tuberous sclerosis complex (TSC) is a multiorgan disease that can lead to hyperactive mTORC1 due to deficient TSC1 or TSC2 protein function. Here, the authors find that despite high mTORC1 activity, TFEB localizes to the nucleus and drives lysosomal
Externí odkaz:
https://doaj.org/article/ec225f1e3e484d6c80c74d6195d73b5c
Autor:
Meng Zhou, Minjeong Ko, Anna C.H. Hoge, Kelsey Luu, Yuzhen Liu, Magdalena L. Russell, William W. Hannon, Zhenwei Zhang, Jian Carrot-Zhang, Rameen Beroukhim, Eliezer M. Van Allen, Atish D. Choudhury, Peter S. Nelson, Matthew L. Freedman, Mary-Ellen Taplin, Matthew Meyerson, Srinivas R. Viswanathan, Gavin Ha
Publikováno v:
JCI Insight, Vol 7, Iss 17 (2022)
The complex genomic landscape of prostate cancer evolves across disease states under therapeutic pressure directed toward inhibiting androgen receptor (AR) signaling. While significantly altered genes in prostate cancer have been extensively defined,
Externí odkaz:
https://doaj.org/article/6032eee655da4206a5a620a0aa119445
Publikováno v:
eLife, Vol 11 (2022)
A splice variant of the androgen receptor that drives prostate cancer resistance translocates into the nucleus using a different mechanism from the full-length receptor and exhibits distinct molecular properties once inside.
Externí odkaz:
https://doaj.org/article/e8bdecead21340bbb6a6fe8073da6ab9