Zobrazeno 1 - 10
of 39
pro vyhledávání: '"R, Van De Straat"'
Publikováno v:
Vromans, R M, Van de Straat, R, Groeneveld, M & Vermeulen, N P 1990, ' One-electron reduction of mitomycin c by rat liver : role of cytochrome P-450 and NADPH-cytochrome P-450 reductase ', Xenobiotica, vol. 20, no. 9, pp. 967-78 . https://doi.org/10.3109/00498259009046912
Xenobiotica, 20(9), 967-78. Informa Healthcare
Xenobiotica, 20(9), 967-78. Informa Healthcare
1. The role of cytochrome P-450 in the one-electron reduction of mitomycin c was studied in rat hepatic microsomal systems and in reconstituted systems of purified cytochrome P-450. Formation of H2O2 from redox cycling of the reduced mitomycin c in t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::06f6edb95a02fa181bb684150f542fd7
https://doi.org/10.3109/00498259009046912
https://doi.org/10.3109/00498259009046912
Publikováno v:
Vermeulen, N P, Bessems, J G & Van de Straat, R 1992, ' Molecular aspects of paracetamol-induced hepatotoxicity and its mechanism-based prevention ', Drug Metabolism Reviews, vol. 24, no. 3, pp. 367-407 . https://doi.org/10.3109/03602539208996298
(1992). Molecular Aspects of Paracetamol-Induced Hepatotoxicity and its Mechanism-Based Prevention. Drug Metabolism Reviews: Vol. 24, No. 3, pp. 367-407.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7eae3b4ec5b2d8c180a7aa4b33dd2aaf
https://pubmed.ncbi.nlm.nih.gov/1628537
https://pubmed.ncbi.nlm.nih.gov/1628537
Publikováno v:
Pharmaceutisch Weekblad. 10:173-177
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::504848d9eac659446b847a7f64dc1e5e
https://doi.org/10.1007/bf01959427
https://doi.org/10.1007/bf01959427
Publikováno v:
Biochemical Pharmacology. 35:3693-3699
The effects of 3-monoalkyl- and 3,5-dialkyl-substitution on the cytotoxicity of paracetamol (PAR) in rat hepatocytes was studied. PAR is known to be bioactivated by the hepatic microsomal cytochrome P-450 containing a mixed-function oxidase system pr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::29f4d4d5f69e16a5a74510312034eecf
https://doi.org/10.1016/0006-2952(86)90653-2
https://doi.org/10.1016/0006-2952(86)90653-2
Publikováno v:
Biochemical Pharmacology. 36:2065-2070
Recently, we have reported that 3,5-dialkyl substitution of paracetamol, in contrast to 3-monoalkyl substitution, prevented the paracetamol-induced toxicity in freshly isolated rat hepatocytes without having any effect on its cytochrome P-450 mediate
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3ee6869b5462107e0dce863331e15964
https://doi.org/10.1016/0006-2952(87)90132-8
https://doi.org/10.1016/0006-2952(87)90132-8
Autor:
C. A. M. Van Ginneken, P. P. Kelder, W. Soudijn, A. Bast, Pieter G. Tepper, J. G. van Gelderen, A. R. Goeptar, J. Wilting, R. van de Straat, H. P. Voss, Lambert H.M. Janssen, P. J. M. Van Galen, S. P. A. Boom, R. M. Vromans, F. J. van Bussel, P. A. v. d. Wouw, W. Möller, J. N. L. Go. R. Leurs, N. P. E. Vermeulen, A. J. G. van Zwam, M. A. H. de Zwart, D. de Kaste, Jan Van der Weide, Aziz Bakri, E. Rekka, G. Damsma, J. B. De Vries, K. J. Lusthof, N. P. E. Vermeiden, G. R. M. M. Haenen, E. L. M. van Sterkenburg, Arijan J. Porsius, P. H. G. M. Willems, E. Mutschler, Octaaf J.M. Bos, J. J. H. H. M. de Pont, J. G. C. Van Amsterdam, J. Wemer, C. Llorens-Cortes, N. Rettenmayr, Lambert H. M. Janssen, W. Vleeming, H. L. M. Siero, G. J. Sterk, J. F. Rodriques de Miranda, H. Timmerman, F. B. Pruijn, J. G. Koper, H. W. Th. van Viijmen, J. Dijk, M. C. A. W. Kuit, H. Van der Goot, J. A. Grimbergen, Frans G. M. Russel, M. J. Plug, H. H. v. Rooij, H. Tendijck, M. Groeneveld, F. J. Bosker, K. Kramer, As Horn, Ad P. IJzerman, Bhc Westerink, G. Lambrecht, A. B. Horn, J. F. Rodrigues De Miranda, Marcel J.E. Fischer, P. Tepper, Jaap Wilting, N. J. de Mol, H. W. Th. van Vlijmen, F. J. J. Leusen, M. Veerman
Publikováno v:
Pharmaceutisch Weekblad. 9:338-345
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9ea15322e52d50d8a9a168e5a0e52b4c
https://doi.org/10.1007/bf01956517
https://doi.org/10.1007/bf01956517
Publikováno v:
Debets, A J, Van de Straat, R, Voogt, T W, Vos, H, Vermeulen, N P & Frei, R W 1988, ' Simultaneous determination of glutathione, glutathione disulphide, paracetamol and its sulphur containing metabolites using HPLC and electrochemical detection with
generated bromine ', Journal of Pharmaceutical and Biomedical Analysis, vol. 6, no. 3, pp. 329-36 . https://doi.org/10.1016/0731-7085(88)80061-X
Journal of Pharmaceutical and Biomedical Analysis, 6(3), 329-36. Elsevier
generated bromine ', Journal of Pharmaceutical and Biomedical Analysis, vol. 6, no. 3, pp. 329-36 . https://doi.org/10.1016/0731-7085(88)80061-X
Journal of Pharmaceutical and Biomedical Analysis, 6(3), 329-36. Elsevier
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2f59233eaa2f210181dd5b5101f155e3
https://hdl.handle.net/1871.1/a771c4b3-2b3b-426d-864f-0ae1ab2fda3e
https://hdl.handle.net/1871.1/a771c4b3-2b3b-426d-864f-0ae1ab2fda3e
Autor:
G. J. Blauw, P. van Brummelen, P. Vermeij, P. A. van Zvieten, H. W. C. M. Boddeke, H. N. Doods, P. A. van Zwieten, A. H. Bom, D. J. Duncker, P. D. Verdouw, P. R. Saxena, M. J. A. P. Daemen, H. T. M. Vervoort-Peters, H. H. W. Thijssen, D. Davidesko, H. D. Batink, H. D. Bangik, K. J. van Charldrop, S. F. de Boer, J. L. Slangen, J. van der Gugten, W. S. De Loos, B. Bohus, W. De Jong, D. De Wied, M. A. H. de Zwart, H. van der Goot, H. Timmerman, A. Garritsen, A. P. IJzerman, W. Soudijn, J. B. Heynis, H. W. G. M. Boddeke, B. J. A. Janssen, H. van Essen, H. A. J. Struyker Boudier, J. F. M. Smits, T. J. W. Jap, C. E. J. Ketelaars, J. Bruinvels, M. J. Krielaart, D. M. J. Veenstra, G. J. T. H. Stolze, L. M. L. le Noble, D. W. Slaaf, G. J. Tangelder, H. C. Neijt, I. J. te Duits, J. J. Plomp, H. P. M. Vijverberg, J. A. M. Raaijmakers, R. J. E. van den Eijnde, F. S. Radhakishun, J. C. Stoof, A. H. Mulder, D. H. G. Versteeg, J. M. van Ree, F. A. M. Redegeld, J. Noordhoek, J. M. H. M. Reul, J. A. D. M. Tonnaer, E. R. de Kloet, J. Riezebos, A. de Jonge, C. G. J. Sweep, V. M. Wiegant, F. Th. M. van Amsterdam, M. Haas, J. Zaagsma, R. G. M. van Amsterdam, F. Brouwer, K. J. van Charldorp, R. van de Straat, J. de Vries, N. P. E. Vermeulden, P. L. M. van Giersbergen, J van Harten, RRECM Zeegers, P van Brumnelen, DD Breimer, P. N. M. van Heiningen, E. J. van Hoogdalem, A. G. de Boer, D. D. Breimer, J. van Wijngaarden, H. Wesseling
Publikováno v:
Pharmaceutisch Weekblad. 8:270-278
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4fba487c10f884e8c4f524c81f871237
https://doi.org/10.1007/bf01960072
https://doi.org/10.1007/bf01960072
Autor:
P. T. M. Biessels, S. Agoston, A. S. Horn, J. G. C. van Amsterdam, K. J. H. van Buuren, W. Soudijn, J. Brussee, A. C. A. Jansen, A. Kühn, T. Buhl, J. F. Rodrigues de Miranda, A. J. Beld, G. Lambrecht, E. Mutschler, T. Bultsma, M. R. Linschoten, H. Timmerman, J. H. M. Dröge, A. A. H. Wachter, H. D. Gaisser, H. van der Goot, H. Timnerman, G. R. M. M. Haenen, A. Bast, H. J. M. Grünbauer, David W. R. Hall, Spencer R. de Wijn, J. de Jong, J. de Vries, S. J. de Klerk, F. H. N. de Haan, J. Kelder, Th. de Boer, J. S. de Graaf, J. H. Wieringa, M. J. Krielaart, D. M. J. Veenstra, O. P. Zuiderveld, N. J. de Mol, Hugo Nieuwenhuyse, J. Koenen, G. R. Mohn, H. J. M. Salden, E. Schonewille, M. J. M. Kothuis, G. J. Sterk, M. W. G. van der Schaar, B. Rademaker, R. van de Straat, H. de Boer, R. M. Vromans, R. P. J. H. Tijms, P. Bosman, J. Zaagsma
Publikováno v:
Pharmaceutisch Weekblad. 6:258-264
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6445ad75734484a73c49cca9ba014896
https://doi.org/10.1007/bf01954556
https://doi.org/10.1007/bf01954556
Publikováno v:
Chemico-Biological Interactions, 64(3), 267-80. Elsevier Ireland Ltd
Van de Straat, R, Vromans, R M, Bosman, P, de Vries, J & Vermeulen, N P 1988, ' Cytochrome P-450-mediated oxidation of substrates by electron-transfer; role of oxygen radicals and of 1-and 2-electron oxidation of paracetamol ', Chemico-Biological Interactions, vol. 64, no. 3, pp. 267-80 . https://doi.org/10.1016/0009-2797(88)90102-0
Van de Straat, R, Vromans, R M, Bosman, P, de Vries, J & Vermeulen, N P 1988, ' Cytochrome P-450-mediated oxidation of substrates by electron-transfer; role of oxygen radicals and of 1-and 2-electron oxidation of paracetamol ', Chemico-Biological Interactions, vol. 64, no. 3, pp. 267-80 . https://doi.org/10.1016/0009-2797(88)90102-0
The mechanism by which the hepatic cytochrome P-450 (Cyt. P-450) containing mixed-function oxidase system oxidizes the analgesic drug paracetamol (PAR) to a hepatotoxic metabolite was studied. Since previous studies excluded the possibility of oxygen
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::82895349e76505a295a6965f0f1e5bab
https://doi.org/10.1016/0009-2797(88)90102-0
https://doi.org/10.1016/0009-2797(88)90102-0