Zobrazeno 1 - 10
of 1 087
pro vyhledávání: '"R, Thoma"'
Autor:
Martin Schröder, Martin Renatus, Xiaoyou Liang, Fabian Meili, Thomas Zoller, Sandrine Ferrand, Francois Gauter, Xiaoyan Li, Frederic Sigoillot, Scott Gleim, Therese-Marie Stachyra, Jason R. Thomas, Damien Begue, Maryam Khoshouei, Peggy Lefeuvre, Rita Andraos-Rey, BoYee Chung, Renate Ma, Benika Pinch, Andreas Hofmann, Markus Schirle, Niko Schmiedeberg, Patricia Imbach, Delphine Gorses, Keith Calkins, Beatrice Bauer-Probst, Magdalena Maschlej, Matt Niederst, Rob Maher, Martin Henault, John Alford, Erik Ahrne, Luca Tordella, Greg Hollingworth, Nicolas H. Thomä, Anna Vulpetti, Thomas Radimerski, Philipp Holzer, Seth Carbonneau, Claudio R. Thoma
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-5 (2024)
Externí odkaz:
https://doaj.org/article/1168651eade84aa68bb9c377c9befbde
Autor:
Martin Schröder, Martin Renatus, Xiaoyou Liang, Fabian Meili, Thomas Zoller, Sandrine Ferrand, Francois Gauter, Xiaoyan Li, Frederic Sigoillot, Scott Gleim, Therese-Marie Stachyra, Jason R. Thomas, Damien Begue, Maryam Khoshouei, Peggy Lefeuvre, Rita Andraos-Rey, BoYee Chung, Renate Ma, Benika Pinch, Andreas Hofmann, Markus Schirle, Niko Schmiedeberg, Patricia Imbach, Delphine Gorses, Keith Calkins, Beatrice Bauer-Probst, Magdalena Maschlej, Matt Niederst, Rob Maher, Martin Henault, John Alford, Erik Ahrne, Luca Tordella, Greg Hollingworth, Nicolas H. Thomä, Anna Vulpetti, Thomas Radimerski, Philipp Holzer, Seth Carbonneau, Claudio R. Thoma
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-19 (2024)
Abstract Targeted protein degradation (TPD) mediates protein level through small molecule induced redirection of E3 ligases to ubiquitinate neo-substrates and mark them for proteasomal degradation. TPD has recently emerged as a key modality in drug d
Externí odkaz:
https://doaj.org/article/8f2eff537f564b01931321a688bb396a
Autor:
Ellen Weisberg, Basudev Chowdhury, Chengcheng Meng, Abigail E. Case, Wei Ni, Swati Garg, Martin Sattler, Abdel Kareem Azab, Jennifer Sun, Barbara Muz, Dana Sanchez, Anthia Toure, Richard M. Stone, Ilene Galinsky, Eric Winer, Scott Gleim, Sofia Gkountela, Alexia Kedves, Edmund Harrington, Tinya Abrams, Thomas Zoller, Andrea Vaupel, Paul Manley, Michael Faller, BoYee Chung, Xin Chen, Philipp Busenhart, Christine Stephan, Keith Calkins, Debora Bonenfant, Claudio R. Thoma, William Forrester, James D. Griffin
Publikováno v:
Blood Cancer Journal, Vol 12, Iss 7, Pp 1-10 (2022)
Abstract Bromodomain-containing protein 9 (BRD9), an essential component of the SWI/SNF chromatin remodeling complex termed ncBAF, has been established as a therapeutic target in a subset of sarcomas and leukemias. Here, we used novel small molecule
Externí odkaz:
https://doaj.org/article/3c275c0fed054a4ca5adaa6cd08da2ce
Autor:
Zachary J. Hauseman, Michelle Fodor, Anxhela Dhembi, Jessica Viscomi, David Egli, Melusine Bleu, Stephanie Katz, Eunyoung Park, Dong Man Jang, Kathryn A. Porter, Fabian Meili, Hongqiu Guo, Grainne Kerr, Sandra Mollé, Camilo Velez-Vega, Kim S. Beyer, Giorgio G. Galli, Saveur-Michel Maira, Travis Stams, Kirk Clark, Michael J. Eck, Luca Tordella, Claudio R. Thoma, Daniel A. King
Publikováno v:
Nature. 609:416-423
RAS–MAPK signalling is fundamental for cell proliferation and is altered in most human cancers1–3. However, our mechanistic understanding of how RAS signals through RAF is still incomplete. Although studies revealed snapshots for autoinhibited an
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8e1147e37a0b43ae1d5465bb277c0ce6
https://doi.org/10.1038/s41586-022-05086-1
https://doi.org/10.1038/s41586-022-05086-1
Autor:
Martin Schröder, Martin Renatus, Xiaoyou Liang, Fabian Meili, Thomas Zoller, Sandrine Ferrand, Francois Gauter, Xiaoyan Li, Fred Sigoillot, Scott Gleim, Marie-Therese Stachyra, Jason Thomas, Damien Begue, Peggy Lefeuvre, Rita Andraos-Rey, BoYee Chung, Renate Ma, Seth Carbonneau, Benika Pinch, Andreas Hofmann, Markus Schirle, Niko Schmiedberg, Patricia Imbach, Delphine Gorses, Keith Calkins, Bea Bauer-Probst, Magdalena Maschlej, Matt Niederst, Rob Maher, Martin Henault, John Alford, Erik Ahrne, Greg Hollingworth, Nicolas H. Thomä, Anna Vulpetti, Thomas Radimerski, Philipp Holzer, Claudio R. Thoma
Targeted protein degradation (TPD) of neo-substrates with proteolysis targeting chimeras (PROTACs) or molecular glues has emerged as a key modality in exploring new biology as well as designing new drug candidates where catalytic inhibition is neithe
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b962ac1012caadf747a15217539d973e
https://doi.org/10.1101/2023.04.09.536153
https://doi.org/10.1101/2023.04.09.536153
Autor:
Wilhelm Krek, Gaudenz Danuser, Katrin L. Gutbrodt, Maria Duda, Kathryn T. Applegate, Claudio R. Thoma, Zlatko Smole
MOV file - 3841K, Movie before (left) and after (right) EB3-GFP comet detection (blue dots) with plusTipTracker, acquisition of 125 frames, 1.25 Hz, 12.5 fold accelerated.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c13cc89b30fbb77f3f7d79964b3291fe
https://doi.org/10.1158/0008-5472.22399274
https://doi.org/10.1158/0008-5472.22399274
Autor:
Wilhelm Krek, Thomas C. Weber, Yann Christinat, Niklaus Fankhauser, Claudio R. Thoma, Michael P. Hell
PDF file - 264KB, Suppl. Fig. 1: Mad2 mRNA translation is specifically reduced upon pVHL knockdown. Suppl. Fig. 2: miR-28-5p targets specific sequences in the Mad2 3'UTR. Suppl. Fig. 3: Overexpression of miR-28-5p induces features of aneuploidy. Supp
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b4a2b6de3acc1c73982027881a06fb4a
https://doi.org/10.1158/0008-5472.22402359.v1
https://doi.org/10.1158/0008-5472.22402359.v1
Autor:
Wilhelm Krek, Gaudenz Danuser, Katrin L. Gutbrodt, Maria Duda, Kathryn T. Applegate, Claudio R. Thoma, Zlatko Smole
MOV file - 4174K, Speed track visualization of Movie 2, speeds between 0 to 30 microm/min are color-coded (bar on the left: min, dark blue to max, dark red).
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5e3b0329dfd332572db4c57906f042b0
https://doi.org/10.1158/0008-5472.22399271
https://doi.org/10.1158/0008-5472.22399271
Autor:
Wilhelm Krek, Gaudenz Danuser, Katrin L. Gutbrodt, Maria Duda, Kathryn T. Applegate, Claudio R. Thoma, Zlatko Smole
PDF file - 1374K, Tubulin tyrosination state in NF2 negative cells.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::48ff2256de4a13158000c49c47cdda19
https://doi.org/10.1158/0008-5472.22399286.v1
https://doi.org/10.1158/0008-5472.22399286.v1
Autor:
Wilhelm Krek, Gaudenz Danuser, Katrin L. Gutbrodt, Maria Duda, Kathryn T. Applegate, Claudio R. Thoma, Zlatko Smole
PDF file - 1573K, Validation of anti-NF2 antibody specificity.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9ec802139a8f68820e53cbd5dfca1d4f
https://doi.org/10.1158/0008-5472.22399289.v1
https://doi.org/10.1158/0008-5472.22399289.v1