Functional analysis of the Aspergillus fumigatus kinome identifies a druggable DYRK kinase that regulates septal plugging

Autor: Norman van Rhijn, Can Zhao, Narjes Al-Furaiji, Isabelle S. R. Storer, Clara Valero, Sara Gago, Harry Chown, Clara Baldin, Rachael-Fortune Grant, Hajer Bin Shuraym, Lia Ivanova, Olaf Kniemeyer, Thomas Krüger, Elaine Bignell, Gustavo H. Goldman, Jorge Amich, Daniela Delneri, Paul Bowyer, Axel A. Brakhage, Hubertus Haas, Michael J. Bromley

Publikováno v: Nature Communications, Vol 15, Iss 1, Pp 1-16 (2024)

Abstract More than 10 million people suffer from lung diseases caused by the pathogenic fungus Aspergillus fumigatus. Azole antifungals represent first-line therapeutics for most of these infections but resistance is rising, therefore the identificat

Externí odkaz: https://doaj.org/article/b48ee6e7b3ac4ef8ac88712d8df32311

Antagonism of the Azoles to Olorofim and Cross-Resistance Are Governed by Linked Transcriptional Networks in Aspergillus fumigatus

Autor: Norman van Rhijn, Sam Hemmings, Isabelle S. R. Storer, Clara Valero, Hajer Bin Shuraym, Gustavo H. Goldman, Fabio Gsaller, Jorge Amich, Michael J. Bromley

Publikováno v: mBio, Vol 13, Iss 6 (2022)

ABSTRACT Aspergillosis, in its various manifestations, is a major cause of morbidity and mortality. Very few classes of antifungal drugs have been approved for clinical use to treat these diseases and resistance to the first-line therapeutic class, t

Externí odkaz: https://doaj.org/article/c043a17d4d58460cb403d9350c5e2b8a

Atacama Cosmology Telescope: A Catalog of >4000 Sunyaev–Zel’dovich Galaxy Clusters

Autor: Eli S. Rykoff, Jo Dunkley, E. Bertin, Ofer Lahav, Nick Battaglia, M. Soares-Santos, Hironao Miyatake, Shannon M. Duff, R. D. Wilkinson, Adriaan J. Duivenvoorden, L. N. da Costa, Joel N. Ullom, Robert Morgan, D. L. Burke, Devin Crichton, Kavilan Moodley, Peter Doel, Alexandra Amon, Edward J. Wollack, N. C. Robertson, H. T. Diehl, Joseph E. Golec, Sunayana Bhargava, Samuel Hinton, Emmanuel Schaan, Enrique Gaztanaga, Megan Gralla, David N. Spergel, Johannes Hubmayr, Simon Dicker, David Bacon, S. Allam, Robert A. Gruendl, Simone Ferraro, C. Aros-Bunster, Felipe Menanteau, G. Gutierrez, Kevin M. Huffenberger, Daniel Thomas, Ramon Miquel, Michael D. Niemack, I. Ferrero, Mathew S. Madhavacheril, J. P. Dietrich, Niall MacCrann, Juan Garcia-Bellido, Tesla E. Jeltema, David J. James, Yanxi Zhang, A. K. Romer, Ben Hoyle, Hy Trac, Mark J. Devlin, Patricio A. Gallardo, J. Gschwend, A. A. Plazas, Brian J. Koopman, Rolando Dünner, Zhilei Xu, Simone Aiola, Behzad Ansarinejad, A. Choi, Jeff McMahon, Eduardo Rozo, Gary Bernstein, K. Honscheid, Michel Aguena, Tanay Bhandarkar, Dan Becker, C. Sifon, Neelima Sehgal, Bhuvnesh Jain, Laura Newburgh, Dongwon Han, F. Paz-Chinchón, J. R. Bond, Kyler Kuehn, Peter Melchior, M. Carrasco Kind, Eve M. Vavagiakis, Steve K. Choi, Suzanne T. Staggs, Paul Giles, R. L. C. Ogando, J. C. Hill, Federico Nati, M. E. C. Swanson, E. V. Denison, Kevin T. Crowley, Tony Mroczkowski, W. G. Hartley, Antonella Palmese, Martine Lokken, S. Kent, Alessandro Schillaci, Masamune Oguri, John P. Hughes, M. A. G. Maia, Maria Salatino, S. Amodeo, T. Shin, S. Adhikari, M. Hasselfield, M. Costanzi, S. I. Loubser, J. Van Lanen, B. Partridge, Sigurd Naess, Adam D. Hincks, J. A. Beall, B. Flaugher, S. M. Simon, Jason E. Austermann, S. P. Ho, John Orlowski-Scherer, M. Smith, Daniel Gruen, J. Martin, D. W. Gerdes, J. Annis, Kenda Knowles, David J. Brooks, Erminia Calabrese, Emilie R. Storer, Gene C. Hilton, Leila R. Vale, Salcedo Romero de Ávila, Phumlani Phakathi, Josh Frieman, Yen-Ting Lin, T. M. C. Abbott, Chun-Hao To, E. J. Sanchez, J. Carretero, E. Suchyta, Matt Hilton, Christopher J. Conselice, Tobias A. Marriage, Sebastian Grandis, A. Carnero Rosell, Agnès Ferté, Anton T. Jaelani, Marcos Lima, S. Everett, S. Serrano, Lyman A. Page, J. De Vicente, Atsushi J. Nishizawa, G. Tarle

Publikováno v: Repositório Institucional da USP (Biblioteca Digital da Produção Intelectual)
Universidade de São Paulo (USP)
instacron:USP
The Astrophysical Journal Supplement Series
Digital.CSIC. Repositorio Institucional del CSIC
instname
Biblos-e Archivo. Repositorio Institucional de la UAM
The Astrophysical Journal Supplement Series, 2021, Vol.253(1), pp.3 [Peer Reviewed Journal]

Hilton, M., et al.
We present a catalog of 4195 optically confirmed Sunyaev–Zel’dovich (SZ) selected galaxy clusters detected with signal-to-noise ratio >4 in 13,211 deg of sky surveyed by the Atacama Cosmology Telescope (ACT). Cluster candi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1069a8930bdccf72f2c515e8fea28197
https://resolver.caltech.edu/CaltechAUTHORS:20210223-132034526

The Atacama Cosmology Telescope: Constraints on Pre-Recombination Early Dark Energy

Autor: J. Colin Hill, Erminia Calabrese, Simone Aiola, Nicholas Battaglia, Boris Bolliet, Steve K. Choi, Mark J. Devlin, Adriaan J. Duivenvoorden, Jo Dunkley, Simone Ferraro, Patricio A. Gallardo, Vera Gluscevic, Matthew Hasselfield, Matt Hilton, Adam D. Hincks, Renée Hložek, Brian J. Koopman, Arthur Kosowsky, Adrien La Posta, Thibaut Louis, Mathew S. Madhavacheril, Jeff McMahon, Kavilan Moodley, Sigurd Naess, Umberto Natale, Federico Nati, Laura Newburgh, Michael D. Niemack, Lyman A. Page, Bruce Partridge, Frank J. Qu, Maria Salatino, Alessandro Schillaci, Neelima Sehgal, Blake D. Sherwin, Cristóbal Sifón, David N. Spergel, Suzanne T. Staggs, Emilie R. Storer, Alexander van Engelen, Eve M. Vavagiakis, Edward J. Wollack, Zhilei Xu

The early dark energy (EDE) scenario aims to increase the value of the Hubble constant ($H_0$) inferred from cosmic microwave background (CMB) data over that found in $\Lambda$CDM, via the introduction of a new form of energy density in the early uni

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c3ae65cb3cc003fbee5c369f6c00b355
https://hal.archives-ouvertes.fr/hal-03356427

The Atacama Cosmology Telescope: DR4 maps and cosmological parameters

Autor: Simone Aiola, Suzanne T. Staggs, C. Sifon, J. Richard Bond, Martine Lokken, Bruce Partridge, Brittany Fuzia, Giampaolo Pisano, Matthew Hasselfield, Vincent Lakey, Shannon M. Duff, H. M. Cho, Naomi Robertson, Brandon S. Hensley, Laura Newburgh, Alexander van Engelen, Jesus Rivera, Kirsten Hall, Matt Hilton, Susan E. Clark, Kavilan Moodley, Rachel Bean, Kent D. Irwin, David Alonso, Andrina Nicola, Edward J. Wollack, Mathew S. Madhavacheril, Dhaneshwar D. Sunder, Brian J. Koopman, David N. Spergel, Rolando Dünner, Jakob M. Helton, Toshiya Namikawa, Zhilei Xu, Sigurd Naess, Leopoldo Infante, Adam D. Hincks, Emily Grace, Renée Hložek, Ningfeng Zhu, Felipe Rojas, Jeff McMahon, Grace E. Chesmore, Jacob Klein, Max Fankhanel, Frank J. Qu, Heather Prince, S. Henderson, Yaqiong Li, Timothy D. Morton, Dale Li, Jason E. Austermann, E. V. Denison, Jason R. Stevens, Robert Thornton, Kenda Knowles, Christine G. Pappas, Amanda MacInnis, Yuhan Wang, Joseph E. Golec, Precious Sikhosana, Adriaan J. Duivenvoorden, Neelima Sehgal, John P. Hughes, Felipe Maldonado, Eve M. Vavagiakis, Peter Charles Hargrave, Sarah Marie Bruno, Michael R. Nolta, Zack Li, Dongwon Han, John P. Nibarger, Sara M. Simon, Jon Sievers, Kasey Wagoner, Blake D. Sherwin, J. Colin Hill, Lyman A. Page, Thibaut Louis, John Orlowski-Sherer, Fernando Zago, Arthur Kosowsky, Benjamin L. Schmitt, Carlos Sierra, Felipe Menanteau, Loïc Maurin, B. Thorne, Vera Gluscevic, Eric R. Switzer, Kevin M. Huffenberger, Marius Lungu, Jo Dunkley, Emilie R. Storer, Felipe Carrero, Gene C. Hilton, Maya Mallaby-Kay, Steve K. Choi, Roberto Puddu, Phumlani Phakathi, Jeff Van Lanen, Jonathan T. Ward, Omar Darwish, Yilun Guan, Maria Salatino, Daniel T. Becker, Anna E. Fox, James A. Beall, Kevin T. Crowley, Federico Nati, Carole Tucker, Alessandro Schillaci, Graeme E. Addison, Shuay-Pwu Patty Ho, Elio Angile, S. Amodeo, Erminia Calabrese, Leila R. Vale, Megan Gralla, Mandana Amiri, Nick Battaglia, Rahul Datta, Peter A. R. Ade, Devin Crichton, Michael D. Niemack, Nicholas F. Cothard, Victoria Calafut, Jesse Treu, Thomas Essinger-Hileman, Cody J. Duell, Luis E. Campusano, Danica Marsden, Rebecca Jackson, Emmanuel Schaan, Johannes Hubmayr, Mark Halpern, Simone Ferraro, Hy Trac, Mark J. Devlin, Patricio A. Gallardo, Maximilian H. Abitbol, Taylor Baildon

Publikováno v: JCAP
JCAP, 2020, 12, pp.047. ⟨10.1088/1475-7516/2020/12/047⟩
Journal of Cosmology and Astroparticle Physics

We present new arcminute-resolution maps of the Cosmic Microwave Background temperature and polarization anisotropy from the Atacama Cosmology Telescope, using data taken from 2013-2016 at 98 and 150 GHz. The maps cover more than 17,000 deg$^2$, the

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1ec7168239e539307679957266062565
https://resolver.caltech.edu/CaltechAUTHORS:20210212-133817397