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Associations Between Extent of Fibrotic Interstitial Lung Disease (ILD) and Forced Vital Capacity (FVC) at Baseline and Change in FVC in Subjects with Systemic Sclerosis-Associated ILD (SSc-ILD) in the SENSCIS Trial

Autor: C. Denton, N. Goh, S.M. Humphries, D.A. Lynch, T.M. Maher, R. Spiera, A. Devaraj, L. Ho, C. Stock, E. Erhardt, M. Alves, A.U. Wells, null on behalf of the SENSCIS trial investigators

Publikováno v: TP24. TP024 UNDERSTANDING AND TREATING AUTOIMMUNE LUNG DISEASE.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::8233c4ff93dc4feb892fb14a6b45d348
https://doi.org/10.1164/ajrccm-conference.2021.203.1_meetingabstracts.a1803

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POS1202 B-CELL RECONSTITUTION IS STRONGLY ASSOCIATED WITH A POSITIVE SEROLOGIC RESPONSE TO THE COVID-19 BOOSTER VACCINE IN PREVIOUSLY SEROLOGICALLY UNRESPONSIVE RITUXIMAB TREATED RHEUMATIC DISEASE PATIENTS

Autor: K. Schultz, D. Jannat-Khah, R. Spiera

Publikováno v: Annals of the Rheumatic Diseases. 81:929.2-930

BackgroundBooster doses of SARS-CoV-2 vaccines have emerged as an important strategy for containing the pandemic and may be especially important to rituximab treated patients. B-cell depletion has been associated with worse outcomes from COVID-19 inf

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::ac4fa054846716a43d20ed20b93736e9
https://doi.org/10.1136/annrheumdis-2022-eular.903

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POS0244 ASSOCIATION OF PROTEINASE 3 GENE (PRTN3) Val119Ile POLYMORPHISM (SNP rs351111) WITH RISK OF RELAPSE AMONG HOMOZYGOUS PATIENTS WITH PR3 ANCA-ASSOCIATED VASCULITIS

Autor: M. Casal Moura, Z. Deng, S. Brooks, W. Tew, A. Hummel, F. Fervenza, C. Kallenberg, C. Langford, P. A. Merkel, P. A. Monach, P. Seo, R. Spiera, W. St. Clair, J. H. Stone, M. Prunotto, P. Grayson, U. Specks

Publikováno v: Annals of the Rheumatic Diseases. 81:361.2-362

BackgroundThe frequency of the proteinase 3 gene (PRTN3) polymorphisms in patients with ANCA-associated vasculitis (AAV) is not well characterized. We hypothesize that PRTN3 gene polymorphisms induce allosteric changes in PR3 conformation which may a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::e7aaf5ac223866af6bca12c9b32d584c
https://doi.org/10.1136/annrheumdis-2022-eular.4977

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AB0626 Prevalence of Frailty in an Internet-Based Cohort with a Self-Reported Diagnosis of Vasculitis – The VascStrong Study

Autor: S. E. Sattui, J. Stadler, C. Burroughs, K. Larson, P. A. Merkel, R. Spiera

Publikováno v: Annals of the Rheumatic Diseases. 81:1439.2-1440

BackgroundFrailty is a syndrome characterized by an increased vulnerability to stressors and is associated with disability and early mortality. Frailty may be accelerated in patients with vasculitis. The prevalence of frailty in patients with vasculi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::8fc1e0e897a0ed8305068c328bf198b9
https://doi.org/10.1136/annrheumdis-2022-eular.3079

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LB0006 SARILUMAB IN PATIENTS WITH RELAPSING POLYMYALGIA RHEUMATICA: A PHASE 3, MULTICENTER, RANDOMIZED, DOUBLE BLIND, PLACEBO CONTROLLED TRIAL (SAPHYR)

Autor: B. Dasgupta, S. Unizony, K. J. Warrington, J. Sloane Lazar, A. Giannelou, C. Nivens, B. Akinlade, W. Wong, Y. Lin, F. Buttgereit, V. Devauchelle-Pensec, A. Rubbert-Roth, R. Spiera

Publikováno v: Annals of the Rheumatic Diseases. 81:210.1-211

BackgroundInterleukin-6 (IL-6) is elevated in patients with active polymyalgia rheumatica (PMR) and is associated with disease activity, relapse and severity. Clinical trials with IL-6 receptor (IL-6R) inhibitors in PMR showed higher remission rates

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::f8b79049745c70f0be69d8c9b2147a27
https://doi.org/10.1136/annrheumdis-2022-eular.5004a

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