Zobrazeno 1 - 10
of 1 182
pro vyhledávání: '"R, Sowers"'
Publikováno v:
International Journal of Molecular Sciences, Vol 25, Iss 2, p 804 (2024)
Clinical and basic studies have documented that both hyperglycemia and insulin-resistance/hyperinsulinemia not only constitute metabolic disorders contributing to cardiometabolic syndrome, but also predispose to diabetic vasculopathy, which refers to
Externí odkaz:
https://doaj.org/article/7814024950a94fa4809e7e9bb7e14ef6
Publikováno v:
Cell Death and Disease, Vol 13, Iss 5, Pp 1-12 (2022)
Abstract The endoplasmic reticulum (ER) and mitochondria are interconnected intracellular organelles with vital roles in the regulation of cell signaling and function. While the ER participates in a number of biological processes including lipid bios
Externí odkaz:
https://doaj.org/article/0a39010b05dc422b84f60357ba774566
Management of hypertension in patients with COVID-19: Implication of angiotensin-converting enzyme 2
Autor:
Guang-Hong Jia, James R Sowers
Publikováno v:
Cardiology Plus, Vol 6, Iss 4, Pp 210-217 (2021)
The global coronavirus disease-19 (COVID-19) pandemic, caused by severe acute respiratory syndrome-coronavirus-2 (SARS-CoV-2), has created an unprecedented, global public health crisis. Epidemiological studies showed that hypertension is a frequent c
Externí odkaz:
https://doaj.org/article/975b8cc12f8b42c897b0c48e6fb443c8
Autor:
James H. Kurasawa, Andrew Park, Carrie R. Sowers, Rebecca A. Halpin, Andrey Tovchigrechko, Claire L. Dobson, Albert E. Schmelzer, Changshou Gao, Susan D. Wilson, Yasuhiro Ikeda
Publikováno v:
Molecular Therapy: Methods & Clinical Development, Vol 19, Iss , Pp 330-340 (2020)
The recombinant adeno-associated virus (AAV) vector is one of the most utilized viral vectors in gene therapy due to its robust, long-term in vivo transgene expression and low toxicity. One major hurdle for clinical AAV applications is large-scale ma
Externí odkaz:
https://doaj.org/article/18e78126ac4a4698ab36a2d608981c8b
Publikováno v:
International Journal of Molecular Sciences, Vol 23, Iss 16, p 8954 (2022)
Systemic insulin resistance is characterized by reduced insulin metabolic signaling and glucose intolerance. Mineralocorticoid receptors (MRs), the principal receptors for the hormone aldosterone, play an important role in regulating renal sodium han
Externí odkaz:
https://doaj.org/article/61df8038ef6c43dfbe1929c32396a47d
Autor:
Annayya R. Aroor, Javad Habibi, Hemanth Kumar Kandikattu, Mona Garro-Kacher, Brady Barron, Dongqing Chen, Melvin R. Hayden, Adam Whaley-Connell, Shawn B. Bender, Thomas Klein, Jaume Padilla, James R. Sowers, Bysani Chandrasekar, Vincent G. DeMarco
Publikováno v:
Cardiovascular Diabetology, Vol 16, Iss 1, Pp 1-15 (2017)
Abstract Background Diastolic dysfunction (DD), a hallmark of obesity and primary defect in heart failure with preserved ejection fraction, is a predictor of future cardiovascular events. We previously reported that linagliptin, a dipeptidyl peptidas
Externí odkaz:
https://doaj.org/article/a266ba0d033d4548a9a0c5f250cb2a1d
Publikováno v:
Cardiovascular Research. 119:691-709
Cardiovascular diseases (CVDs) arise from a complex interplay among genomic, proteomic, and metabolomic abnormalities. Emerging evidence has recently consolidated the presence of robust DNA damage in a variety of cardiovascular disorders. DNA damage
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4df49b3de7353c43dad64550c018bf07
https://doi.org/10.1093/cvr/cvac080
https://doi.org/10.1093/cvr/cvac080
Autor:
Javad Habibi, Dongqing Chen, Jack L. Hulse, Adam Whaley-Connell, James R. Sowers, Guanghong Jia
Publikováno v:
Am J Physiol Regul Integr Comp Physiol
Mineralocorticoid receptor (MR) activation plays an important role in hepatic insulin resistance. However, the precise mechanisms by which MR activation promotes hepatic insulin resistance remains unclear. Therefore, we sought to investigate the role
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c5ca502f7721c0837685ae442dfa02b9
https://doi.org/10.1152/ajpregu.00316.2021
https://doi.org/10.1152/ajpregu.00316.2021
Autor:
Guanghong Jia, James R. Sowers
Publikováno v:
Hypertension (Dallas, Tex. : 1979)
Epidemiological studies have documented that insulin resistance and diabetes not only constitute metabolic abnormalities but also predispose to hypertension, vascular stiffness, and associated cardiovascular disease. Meanwhile, excessive arterial sti
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e29b7625809bc0e1d1260a893078909b
https://doi.org/10.1161/hypertensionaha.121.17981
https://doi.org/10.1161/hypertensionaha.121.17981
Autor:
Annayya Aroor, Vincent G. DeMarco, Adam T. Whaley-Connell, Guanghong Jia, Yan Yang, Neekun Sharma, Huma Naz, Chetan Hans, Melvin R. Hayden, Michael A. Hill, James R. Sowers, Camila Manrique-Acevedo, Guido Lastra
Publikováno v:
American journal of physiology. Regulatory, integrative and comparative physiology. 324(1)
Widespread consumption of diets high in fat and fructose (Western diet, WD) has led to increased prevalence of obesity and diastolic dysfunction (DD). DD is a prominent feature of heart failure with preserved ejection fraction (HFpEF). However, the u
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2724204fd3c16202316581a20c0dcbec
https://pubmed.ncbi.nlm.nih.gov/36440901
https://pubmed.ncbi.nlm.nih.gov/36440901