Zobrazeno 1 - 10
of 2 455
pro vyhledávání: '"R, Simmons"'
Autor:
Trevor R. Simmons, Gina Partipilo, Ryan Buchser, Anna C. Stankes, Rashmi Srivastava, Darian Chiu, Benjamin K. Keitz, Lydia M. Contreras
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-13 (2024)
Abstract As synthetic biology expands, creating “drag-and-drop” regulatory tools that can achieve diverse regulatory outcomes are paramount. Herein, we develop a approach for engineering complex post-transcriptional control by rewiring the Carbon
Externí odkaz:
https://doaj.org/article/09aa27b77c0b4285b71268b39ddc51a0
Autor:
Shaunna R. Simmons, Sydney E. Herring, Essi Y.I Tchalla, Alexsandra P. Lenhard, Manmeet Bhalla, Elsa N. Bou Ghanem
Publikováno v:
Immunity & Ageing, Vol 21, Iss 1, Pp 1-16 (2024)
Abstract Background Streptococcus pneumoniae (pneumococcus) is a leading cause of pneumonia in older adults. Successful control of pneumococci requires robust pulmonary neutrophil influx early in infection. However, aging is associated with aberrant
Externí odkaz:
https://doaj.org/article/a0088b32a3fa4a859bfdf3c0ef6bd898
Autor:
Gina Partipilo, Yang Gao, Alexis J Holwerda, Yassir Lekbach, Ismar E Miniel Mahfoud, Trevor R Simmons, Bailey M Tibbett, Rebecca E Wilen, Marcus S Benyamin, Benjamin K Keitz
Publikováno v:
eLife, Vol 13 (2024)
Troubleshooting is an important part of experimental research, but graduate students rarely receive formal training in this skill. In this article, we describe an initiative called Pipettes and Problem Solving that we developed to teach troubleshooti
Externí odkaz:
https://doaj.org/article/832b5660239a4084988ca339d09d4491
Autor:
Ali F. Almutairy, Abdullah S. Alhamed, Stephen G. Grant, Miranda J. Falso, Billy W. Day, Colton R. Simmons, Jean J. Latimer
Publikováno v:
Frontiers in Oncology, Vol 14 (2024)
IntroductionBreast cancer (BC) is the most common cancer affecting women in the United States. Ductal carcinoma in situ (DCIS) is the earliest identifiable pre-invasive BC lesion. Estimates show that 14 to 50% of DCIS cases progress to invasive BC.Me
Externí odkaz:
https://doaj.org/article/c4c90ea8dbcc4d48ad9f8cd113153a3d
Autor:
Nicholas P. Storer, Abigail R. Simmons, Jordan Sottosanto, Jennifer A. Anderson, Ming Hua Huang, Debbie Mahadeo, Carey A. Mathesius, Mitscheli Sanches da Rocha, Shuang Song, Ewa Urbanczyk-Wochniak
Publikováno v:
Frontiers in Bioengineering and Biotechnology, Vol 12 (2024)
Genetically modified (GM) crops that have been engineered to express transgenes have been in commercial use since 1995 and are annually grown on 200 million hectares globally. These crops have provided documented benefits to food security, rural econ
Externí odkaz:
https://doaj.org/article/da08430d87944a6c8b32e8f0282d8667
Publikováno v:
BMC Pregnancy and Childbirth, Vol 23, Iss 1, Pp 1-7 (2023)
Abstract Background The United Kingdom (UK) has committed to the World Health Organization’s viral hepatitis elimination targets. New case finding strategies, such as antenatal testing, may be needed to achieve these targets. We conducted a rapid r
Externí odkaz:
https://doaj.org/article/c437d255217a412586bc975038fb03ca
Autor:
Shuichi Nakai, Andrew F. Roberts, Abigail R. Simmons, Kazuyuki Hiratsuka, Douglas W. Miano, Facundo Vesprini
Publikováno v:
Frontiers in Bioengineering and Biotechnology, Vol 12 (2024)
The concept of Data Transportability (DT) of Confined Field Testing (CFT) to support the Environmental Risk Assessment (ERA) of Genetically Modified (GM) plants was first introduced in the literature by Garcia-Alonso et al., in 2014. Since then, DT h
Externí odkaz:
https://doaj.org/article/1eccf6626fb447e7bdccda92c013c526
Autor:
Alejandra Matsuri Rojano-Nisimura, Trevor R. Simmons, Abigail N. Leistra, Mia K. Mihailovic, Ryan Buchser, Alyssa M. Ekdahl, Isabella Joseph, Nicholas C. Curtis, Lydia M. Contreras
Publikováno v:
Frontiers in Molecular Biosciences, Vol 10 (2023)
Post-transcriptional regulation, by small RNAs (sRNAs) as well as the global Carbon Storage Regulator A (CsrA) protein, play critical roles in bacterial metabolic control and stress responses. The CsrA protein affects selective sRNA-mRNA networks, in
Externí odkaz:
https://doaj.org/article/f4a81de5c79e4ef7ba13bd3d7ef2b000
Autor:
Liubov V. Gushchina, Tatyana A. Vetter, Emma C. Frair, Adrienne J. Bradley, Kelly M. Grounds, Jacob W. Lay, Nianyuan Huang, Aisha Suhaiba, Frederick J. Schnell, Gunnar Hanson, Tabatha R. Simmons, Nicolas Wein, Kevin M. Flanigan
Publikováno v:
Molecular Therapy: Nucleic Acids, Vol 30, Iss , Pp 479-492 (2022)
Duchenne muscular dystrophy (DMD) is a devastating muscle-wasting disease that arises due to the loss of dystrophin expression, leading to progressive loss of motor and cardiorespiratory function. Four exon-skipping approaches using antisense phospho
Externí odkaz:
https://doaj.org/article/c58f1dc6613c474f8ea734b55a626d47
Autor:
Kevin M. Flanigan, Tatyana A. Vetter, Tabatha R. Simmons, Megan Iammarino, Emma C. Frair, Federica Rinaldi, Louis G. Chicoine, Johan Harris, John P. Cheatham, Sharon L. Cheatham, Brian Boe, Megan A. Waldrop, Deborah A. Zygmunt, Davin Packer, Paul T. Martin
Publikováno v:
Molecular Therapy: Methods & Clinical Development, Vol 27, Iss , Pp 47-60 (2022)
In a phase 1/2, open-label dose escalation trial, we delivered rAAVrh74.MCK.GALGT2 (also B4GALNT2) bilaterally to the legs of two boys with Duchenne muscular dystrophy using intravascular limb infusion. Subject 1 (age 8.9 years at dosing) received 2.
Externí odkaz:
https://doaj.org/article/5d4cb4d3fc0f4849bd3ccf973f1e61e1