Zobrazeno 1 - 10
of 48
pro vyhledávání: '"R, Scherkl"'
Publikováno v:
Epilepsy Research. 10:111-118
The influence of drugs affecting the turnover and levels of histamine in brain and histamine antagonists on pentetrazole (PTZ)-induced and electroconvulsive seizure threshold in mice was studied. A 1.5-2-fold rise in histamine brain concentration (in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::28fd5caa6a651a9846f52d28408c508e
https://doi.org/10.1016/0920-1211(91)90003-x
https://doi.org/10.1016/0920-1211(91)90003-x
Publikováno v:
DTW. Deutsche tierarztliche Wochenschrift. 103(5)
Determination of pharmacokinetic data from plasma often is not sufficient in order to predict or to explain the clinical efficacy of drugs, e.g., in non steroidal antiinflammatory drugs (NSAID) with short elimination half lives in plasma a discrepanc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::812982dbc091b9e14975e5d5c92cfd7d
https://pubmed.ncbi.nlm.nih.gov/8964239
https://pubmed.ncbi.nlm.nih.gov/8964239
Publikováno v:
Archives internationales de pharmacodynamie et de therapie. 325
By means of tissue cages in which a sterile inflammation was induced after injection of carrageenan, plasma and tissue kinetics of two NSAIDs were followed. The first one, phenylbutazone, is characterized by a fairly short elimination half-life (3-6
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::47d9ee408bdbe4467595b64da950d765
https://pubmed.ncbi.nlm.nih.gov/8110026
https://pubmed.ncbi.nlm.nih.gov/8110026
Publikováno v:
DTW. Deutsche tierarztliche Wochenschrift. 99(10)
Acepromazine is extensively used in veterinary practice. In dogs, it is used mainly as a preanaesthetic and sedative agent, without the knowledge of pharmacokinetic data in this species. We studied the disposition both after oral and intravenous admi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::2e7eff656b16c442b30f34478b1192c2
https://pubmed.ncbi.nlm.nih.gov/1425314
https://pubmed.ncbi.nlm.nih.gov/1425314
Publikováno v:
Epilepsy research. 8(3)
Mice were treated for 14 days with clonazepam, 0.5 mg/kg i.p. twice daily, during which time partial tolerance to the anticonvulsant effect against pentetrazole developed. The development of tolerance was paralleled by a reduced turnover of noradrena
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1a475b368209b7324c43698b1824df6a
https://pubmed.ncbi.nlm.nih.gov/1868819
https://pubmed.ncbi.nlm.nih.gov/1868819
Publikováno v:
Agents and actions. Supplements. 33
The influence of drugs affecting the turnover of histamine in brain and histamine antagonists on pentetrazole seizure threshold in mice was studied. A rise in histamine brain concentration as well as treatment with central acting H1-, but not H2- and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::b3fdcbd89907f67e448f11342375b997
https://pubmed.ncbi.nlm.nih.gov/1675837
https://pubmed.ncbi.nlm.nih.gov/1675837
Publikováno v:
New Perspectives in Histamine Research ISBN: 9783034873116
The influence of drugs affecting the turnover of histamine in brain and histamine antagonists on pentetrazole seizure threshold in mice was studied. A rise in histamine brain concentration as well as treatment with central acting H1-, but not H2- and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1ec0e2d5d1f5871df6fd5b9799c8690a
https://doi.org/10.1007/978-3-0348-7309-3_6
https://doi.org/10.1007/978-3-0348-7309-3_6
Publikováno v:
The Journal of pharmacology and experimental therapeutics. 255(2)
Abecarnil (ZK 112119; isopropyl-6-benzyloxy-4-methoxymethyl-beta-carboline-3-carboxylate), a novel beta-carboline with high affinity for central benzodiazepine (BZ) receptors, has been shown recently to be a potent anxiolytic and anticonvulsant in an
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::06240f270160e84cdd171b84f4e06aa4
https://pubmed.ncbi.nlm.nih.gov/1978730
https://pubmed.ncbi.nlm.nih.gov/1978730
Publikováno v:
Journal of veterinary pharmacology and therapeutics. 13(2)
Apomorphine proved to be more effective as an emetic in dogs after s.c. administration than after i.m. injection with doses of 0.04 and 0.1 mg/kg. This effect is explained by an anti-emetic effect mediated by mu-receptors in the vomiting centre in th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::25b558c7133641207457cfbbe136d292
https://pubmed.ncbi.nlm.nih.gov/2384906
https://pubmed.ncbi.nlm.nih.gov/2384906
Publikováno v:
Archives internationales de pharmacodynamie et de therapie. 305
In previous studies, development of functional tolerance to the anticonvulsant effect of clonazepam and physical dependence on the drug have been demonstrated. In the present study, dogs were treated for 6 weeks with clonazepam 0.5 mg/kg b.i.d. Under
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::9ee31423a10dcd0516a409d5f56f13f3
https://pubmed.ncbi.nlm.nih.gov/1700684
https://pubmed.ncbi.nlm.nih.gov/1700684