Zobrazeno 1 - 10
of 696
pro vyhledávání: '"R, Sachs"'
Autor:
Margaret C. Slack, MD, Samantha Sovich, MD, Chana R. Sachs, MD, Dorothy Martinez, MD, Run Yu, MD
Publikováno v:
AACE Clinical Case Reports, Vol 10, Iss 5, Pp 184-187 (2024)
Background/Objective: Nonislet cell tumor hypoglycemia (NICTH) is an uncommon cause of hypoglycemia due to a relative surplus of insulin-like growth factor 2 (IGF-2) or its precursor molecule. The diagnosis is confirmed by an elevated ratio of IGF-2
Externí odkaz:
https://doaj.org/article/84a82c3fa3b84d91b09220ee337aede7
Autor:
Josiah Ryman, Jeffrey R. Sachs, Natalie Banniettis, Thomas Weiss, Maurice Ahsman, Ka Lai Yee, Jessica Weaver
Publikováno v:
Expert Review of Vaccines, Vol 23, Iss 1, Pp 467-473 (2024)
ABSTRACTBackground Next generation, higher valency pneumococcal conjugate vaccines (PCVs) are assessed and licensed by comparing the immune response across serotypes shared with the PCVs that are standard of care for prevention of pneumococcal diseas
Externí odkaz:
https://doaj.org/article/da5b7b5fa7ff48d19e008136d16f17f4
Publikováno v:
Expert Review of Vaccines, Vol 23, Iss 1, Pp 60-68 (2024)
ABSTRACTBackground Next-generation, higher-valency pneumococcal conjugate vaccines (PCVs), 15-valent PCV V114 and 20-valent PCV (PCV20), have been assessed by comparing their immune responses across serotypes shared with the 13-valent PCV (PCV13). Wi
Externí odkaz:
https://doaj.org/article/95e52e182b40446d82a5d7caa306b2c9
Publikováno v:
BMC Medical Research Methodology, Vol 24, Iss 1, Pp 1-15 (2024)
Abstract Background Vaccine efficacy (VE) assessed in a randomized controlled clinical trial can be affected by demographic, clinical, and other subject-specific characteristics evaluated as baseline covariates. Understanding the effect of covariates
Externí odkaz:
https://doaj.org/article/02fd0993cd9e481f9c476bec0b21cf57
Publikováno v:
npj Vaccines, Vol 7, Iss 1, Pp 1-7 (2022)
Abstract The strength of the immune response, as measured by antibody concentrations, varies between pneumococcal conjugate vaccines (PCVs). Linking immunogenicity and effectiveness is necessary to assess whether changes in immune response from curre
Externí odkaz:
https://doaj.org/article/e330ffd1d59845498eda3101f78ba2fa
Autor:
Daniel I. S. Rosenbloom, Julie Dudášová, Casey Davis, Radha A. Railkar, Nitin Mehrotra, Jeffrey R. Sachs
Publikováno v:
Vaccines, Vol 11, Iss 9, p 1501 (2023)
In vaccine efficacy trials, inaccurate counting of infection cases leads to systematic under-estimation—or “dilution”—of vaccine efficacy. In particular, if a sufficient fraction of observed cases are false positives, apparent efficacy will b
Externí odkaz:
https://doaj.org/article/9338473b398c4b5fa038fff778f3ca24
Autor:
Neda A Moatamed, Saba Vahdatshariatpanahi, David W Gjertson, Chana R Sachs, Yuna Kang, Nora Ostrzega, Jiaoti Huang, Sanaz Memarzadeh
Publikováno v:
PLoS ONE, Vol 18, Iss 9, p e0291361 (2023)
IntroductionThe expression of androgen receptor (AR) is not commonly tested or studied in uterine cancers, unlike estrogen receptor (ER) and progesterone receptor (PR) which are positive in most endometrial carcinomas. In this series, we evaluated th
Externí odkaz:
https://doaj.org/article/cbba4b07c1d441809db5e10b1f8b0593
Autor:
Julie Dudášová, Regina Laube, Chandni Valiathan, Matthew C. Wiener, Ferdous Gheyas, Pavel Fišer, Justina Ivanauskaite, Frank Liu, Jeffrey R. Sachs
Publikováno v:
npj Vaccines, Vol 6, Iss 1, Pp 1-14 (2021)
Abstract Vaccine efficacy is often assessed by counting disease cases in a clinical trial. A new quantitative framework proposed here (“PoDBAY,” Probability of Disease Bayesian Analysis), estimates vaccine efficacy (and confidence interval) using
Externí odkaz:
https://doaj.org/article/415ecc810f6745a2bf96f13f021d869a
Publikováno v:
CPT: Pharmacometrics & Systems Pharmacology, Vol 10, Iss 9, Pp 1092-1106 (2021)
Abstract Pharmacometric models can enhance clinical decision making, with covariates exposing potential contributions to variability of subpopulation characteristics, for example, demographics or disease status. Intuitive visualization of models with
Externí odkaz:
https://doaj.org/article/c21fd9582c8f4d6bb77d5556f2d45d1d
Autor:
Bhargava Kandala, Nele Plock, Akshita Chawla, Anna Largajolli, Seth Robey, Kenny Watson, Raj Thatavarti, Sheri A. Dubey, S.Y. Amy Cheung, Rik de Greef, Julie Stone, Jeffrey R. Sachs
Publikováno v:
EBioMedicine, Vol 84, Iss , Pp 104264- (2022)
Summary: Background: The COVID-19 pandemic has increased the need for innovative quantitative decision tools to support rapid development of safe and efficacious vaccines against SARS-CoV-2. To meet that need, we developed and applied a model-based m
Externí odkaz:
https://doaj.org/article/de1aa37726f44b35900d070763f50f39