Zobrazeno 1 - 10
of 797
pro vyhledávání: '"R, Roque"'
Publikováno v:
Emerging Trends in Drugs, Addictions, and Health, Vol 4, Iss , Pp 100118- (2024)
Introduction: Synthetic cannabinoids (SC) display a pharmacological mechanism similar to that of Δ9-tetrahydrocannabinol (THC), the key active principle of cannabis. SC are full agonists with higher potency at the CB1 and CB2 receptors, contrasting
Externí odkaz:
https://doaj.org/article/f204c5d2cf4c495c9d10e6718da2876b
Autor:
Sandra Marques e Silva, Ândrea V. F. Chaves, Murillo O. Antunes, Natalia R. Roque, Eduarda M. S. Montenegro, Isabelle Malbouisson, Maurício A. de Paula, Edileide B. Correia
Publikováno v:
Journal of Inborn Errors of Metabolism and Screening, Vol 12 (2024)
Abstract Fabry disease (FD) is a rare, x-linked lysosomal storage disease caused by mutations in the GLA gene that leads to total or partial alfa galactosidase A deficiency. Its prevalence ranges between 1:117,000 and 1:8,454. Mutations in the GLA ge
Externí odkaz:
https://doaj.org/article/0739f9c20d3e492a81052c6299d783b6
Autor:
Guangxu Xu, Ziyi Zhao, Weiya Z. Wysham, Dario R. Roque, Ziwei Fang, Wenchuan Sun, Yajie Yin, Boer Deng, Xiaochang Shen, Chunxiao Zhou, Victoria Bae-Jump
Publikováno v:
Frontiers in Oncology, Vol 13 (2023)
IntroductionAmong all cancers, endometrial cancer is most strongly associated with obesity, with more than 65% of endometrial cancers attributable to obesity and being overweight. Fatty acid synthase (FAS), a key lipogenic enzyme, is expressed in end
Externí odkaz:
https://doaj.org/article/427e4750c2fb4b57b74994c44a71feb7
Autor:
Reinaldo B. Oriá, Deiziane V.S. Costa, Pedro Henrique Q.S. de Medeiros, Cássia R. Roque, Ronaldo P. Dias, Cirle A. Warren, David T. Bolick, Richard L. Guerrant
Publikováno v:
Brazilian Journal of Infectious Diseases, Vol 27, Iss 3, Pp 102776- (2023)
Cryptosporidiosis is a waterborne protozoal infection that may cause life-threatening diarrhea in undernourished children living in unsanitary environments. The aim of this study is to identify new biomarkers that may be related to gut-brain axis dys
Externí odkaz:
https://doaj.org/article/1109d467212442c49b302fe78a8ac747
Akademický článek
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Autor:
O. Alvarez-Campos, E. J. Olson, L. R. Welp, M. D. Frisbee, S. A. Zuñiga Medina, J. Díaz Rodríguez, W. R. Roque Quispe, C. I. Salazar Mamani, M. R. Arenas Carrión, J. M. Jara, A. Ccanccapa-Cartagena, C. T. Jafvert
Publikováno v:
Hydrology and Earth System Sciences, Vol 26, Pp 483-503 (2022)
Improving our understanding of hydrogeological processes on the western flank of the central Andes is critical to communities living in this arid region. Groundwater emerging as springs at low elevations provides water for drinking, agriculture, and
Externí odkaz:
https://doaj.org/article/725206d68c5f4c5c85b057f607a3fe81
Publikováno v:
Frontiers in Environmental Science, Vol 11 (2023)
The Peruvian Amazon is known for harboring the greatest biodiversity on the planet, with a world record for biodiversity per unit area. Previous studies suggested that the high ecological value depends on correlations between ecosystem functionality
Externí odkaz:
https://doaj.org/article/27ab9a4c9a394a2e9f8f075628f251bf
Autor:
Esthefany S. Rodrigues, Gilbert Q. Santos, Marlon Vicente da Silva, Juliana H. S. Barros, Aline R. Bernardo, Rafaela L. Diniz, Nara M. Rubim, André L. R. Roque, Ana Maria Jansen, Edimilson D. Silva, Samanta C. C. Xavier
Publikováno v:
Frontiers in Cellular and Infection Microbiology, Vol 12 (2022)
Canis lupus familiaris (domestic dog) represents a reliable sentinel for the occurrence of a well-established transmission cycle of Trypanosoma cruzi among wild mammals in the surroundings and, consequently, where the risk of human infection exists.
Externí odkaz:
https://doaj.org/article/4fda252948fb40a3b32d3f83cd506814
Autor:
Reinaldo B. Oriá, Raul S. Freitas, Cássia R. Roque, José Carlos R. Nascimento, Ana Paula Silva, João O. Malva, Richard L. Guerrant, Michael P. Vitek
Publikováno v:
Pharmaceutics, Vol 15, Iss 4, p 1086 (2023)
Apolipoprotein E (apoE) mimetic peptides are engineered fragments of the native apoE protein’s LDL-receptor binding site that improve the outcomes following a brain injury and intestinal inflammation in a variety of models. The vicious cycle of ent
Externí odkaz:
https://doaj.org/article/27e4080c75d24c9d91fc6f8a9bacae1e
Autor:
Dario R. Roque, Lu Zhang, Weiya Z. Wysham, Jianjun Han, Wenchuan Sun, Yajie Yin, James N. Livingston, Ken W. Batchelor, Chunxiao Zhou, Victoria L. Bae-Jump
Publikováno v:
Frontiers in Oncology, Vol 11 (2021)
ObjectivesAnti-diabetic biguanide drugs such as metformin may have anti-tumorigenic effects by behaving as AMPK activators and mTOR inhibitors. Metformin requires organic cation transporters (OCTs) for entry into cells, and NT-1044 is an AMPK activat
Externí odkaz:
https://doaj.org/article/d5fdb5755f304952abf348c1f42431bd