Zobrazeno 1 - 10
of 240
pro vyhledávání: '"R, Richie"'
Autor:
Jean-David Larouche, Céline M Laumont, Assya Trofimov, Krystel Vincent, Leslie Hesnard, Sylvie Brochu, Caroline Côté, Juliette F Humeau, Éric Bonneil, Joel Lanoix, Chantal Durette, Patrick Gendron, Jean-Philippe Laverdure, Ellen R Richie, Sébastien Lemieux, Pierre Thibault, Claude Perreault
Publikováno v:
eLife, Vol 12 (2024)
Transposable elements (TEs) are repetitive sequences representing ~45% of the human and mouse genomes and are highly expressed by medullary thymic epithelial cells (mTECs). In this study, we investigated the role of TEs on T-cell development in the t
Externí odkaz:
https://doaj.org/article/f8e5dc8f11474cf292db53bbc1880f9d
Autor:
Jovanka Gencel-Augusto, Xiaoping Su, Yuan Qi, Elizabeth M. Whitley, Vinod Pant, Shunbin Xiong, Vrutant Shah, Jerome Lin, Encarnacion Perez, Marta L. Fiorotto, Iqbal Mahmud, Abhinav K. Jain, Philip L. Lorenzi, Nicholas E. Navin, Ellen R. Richie, Guillermina Lozano
Publikováno v:
Cancer Discovery. 13:1230-1249
Cancer-related alterations of the p53 tetramerization domain (TD) abrogate wild-type (WT) p53 function. They result in a protein that preferentially forms monomers or dimers, which are also normal p53 states under basal cellular conditions. However,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ec38a26d586b90444ae5702d92d18536
https://doi.org/10.1158/2159-8290.cd-22-0872
https://doi.org/10.1158/2159-8290.cd-22-0872
Autor:
Jayashree Srinivasan, Jessica N. Lancaster, Nandini Singarapu, Laura P. Hale, Lauren I. R. Ehrlich, Ellen R. Richie
Publikováno v:
Frontiers in Immunology, Vol 12 (2021)
Thymic epithelial cells (TECs) and hematopoietic antigen presenting cells (HAPCs) in the thymus microenvironment provide essential signals to self-reactive thymocytes that induce either negative selection or generation of regulatory T cells (Treg), b
Externí odkaz:
https://doaj.org/article/051e6390cc1b4809b02d130a805425df
Autor:
Jayashree Srinivasan, Anusha Vasudev, Carolyn Shasha, Hilary J. Selden, Encarnacion Perez, Bonnie LaFleur, Shripad A. Sinari, Andreas Krueger, Ellen R. Richie, Lauren I. R. Ehrlich
Publikováno v:
Aging Cell.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::cc3501512f550861374a489870f54b9a
https://doi.org/10.1111/acel.13870
https://doi.org/10.1111/acel.13870
Autor:
Guillermina Lozano, Ellen R. Richie, Nicholas E. Navin, Philip L. Lorenzi, Abhinav K. Jain, Iqbal Mahmud, Marta L. Fiorotto, Encarnacion Perez, Jerome Lin, Vrutant Shah, Shunbin Xiong, Vinod Pant, Elizabeth M. Whitley, Yuan Qi, Xiaoping Su, Jovanka Gencel-Augusto
Cancer-related alterations of the p53 tetramerization domain (TD) abrogate wild-type (WT) p53 function. They result in a protein that preferentially forms monomers or dimers, which are also normal p53 states under basal cellular conditions. However,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1d9976fcab245f95317df38198617cf8
https://doi.org/10.1158/2159-8290.c.6603197.v2
https://doi.org/10.1158/2159-8290.c.6603197.v2
Autor:
Guillermina Lozano, Ellen R. Richie, Nicholas E. Navin, Philip L. Lorenzi, Abhinav K. Jain, Iqbal Mahmud, Marta L. Fiorotto, Encarnacion Perez, Jerome Lin, Vrutant Shah, Shunbin Xiong, Vinod Pant, Elizabeth M. Whitley, Yuan Qi, Xiaoping Su, Jovanka Gencel-Augusto
Table S1 shows predicted off target sites for p53TD mutant mice. Table S2 shows upregulated PPAR target genes in p53AD vs p53-null. Table S3 shows ATAC-seq and RNA-seq congruent genes in p53AD vs p53 null. Table S4 shows p53half site analysis in PPAR
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6b03b2a491efd58e37db58aff38c7ea7
https://doi.org/10.1158/2159-8290.22645274.v1
https://doi.org/10.1158/2159-8290.22645274.v1
Autor:
Jessica N. Lancaster, Damaris E. Keatinge‐Clay, Jayashree Srinivasan, Yu Li, Hilary J. Selden, Seohee Nam, Ellen R. Richie, Lauren I. R. Ehrlich
Publikováno v:
Aging cell. 21(6)
One of the earliest hallmarks of immune aging is thymus involution, which not only reduces the number of newly generated and exported T cells, but also alters the composition and organization of the thymus microenvironment. Thymic T-cell export conti
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a69c98114cc0d649c6f96e4293c0dcee
https://pubmed.ncbi.nlm.nih.gov/35561351
https://pubmed.ncbi.nlm.nih.gov/35561351
Autor:
Dakshayani Lomada, Manju Jain, Michelle Bolner, Kaitlin A G Reeh, Rhea Kang, Madhava C Reddy, John DiGiovanni, Ellen R Richie
Publikováno v:
PLoS Genetics, Vol 12, Iss 1, p e1005777 (2016)
Medullary thymic epithelial cells (mTECs) are essential for establishing central tolerance by expressing a diverse array of self-peptides that delete autoreactive thymocytes and/or divert thymocytes into the regulatory T cell lineage. Activation of t
Externí odkaz:
https://doaj.org/article/bd9cef4d6eaa4f879fec99357967910e
Autor:
Dipayan Paul, F. Ghebru, Margot Kuitems, P. Wietzes-Land, Michael W. Dee, S de Bruijn, Harro A. J. Meijer, Sanne W.L. Palstra, B. M. A. A. Verstappen-Dumoulin, D. Van Zonneveld, R. R. Richie, H. G. Jansen, M. O. Bleeker, A. Th. Aerts-Bijma, Andrea Scifo, J. J. Spriensma
Publikováno v:
Radiocarbon
Radiocarbon, 62(1), 63-74. UNIV ARIZONA DEPT GEOSCIENCES
Radiocarbon, 62(1), 63-74. UNIV ARIZONA DEPT GEOSCIENCES
The Centre for Isotope Research (CIO) at the University of Groningen has operated a radiocarbon (14C) dating laboratory for almost 70 years. In 2017, the CIO received a major upgrade, which involved the relocation of the laboratory to new purpose-bui
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6542ca0a1e0718ec47f6ca7c6909e8c3
https://hdl.handle.net/11370/c9cad370-b7e5-4368-83d2-27f7e77dca43
https://hdl.handle.net/11370/c9cad370-b7e5-4368-83d2-27f7e77dca43
Autor:
Jayashree Srinivasan, Anusha Vasudev, Hilary J. Selden, Encarnacion Perez, Bonnie LaFleur, Shripad A. Sinari, Andreas Krueger, Ellen R. Richie, Lauren I. R. Ehrlich
Age-related thymus involution results in decreased T-cell production, contributing to increased susceptibility to pathogens. Elucidating mechanisms underlying involution will inform strategies to restore thymopoiesis. The thymus is colonized by circu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9a8edec147e0db3342c6ea50ddd0f567
https://doi.org/10.1101/2022.01.18.476832
https://doi.org/10.1101/2022.01.18.476832