Abstracts from the 2011 BNOS Conference, June 29 - July 1, 2011, Homerton College, Cambridge

Autor: S. Ammoun, L. Zhou, M. Barczyk, D. Hilton, S. Hafizi, C. Hanemann, K. S. Lehnus, L. K. Donovan, G. J. Pilkington, Q. An, I. A. Anderson, S. Thomson, M. Bailey, E. Lekka, J. Law, C. Davis, K. Banfill, C. Loughrey, P. Hatfield, D. Bax, R. Elliott, R. Bishop, K. Taylor, L. Marshall, N. Gaspar, M. Viana-Pereira, R. Reis, J. Renshaw, A. Ashworth, C. Lord, C. Jones, C. Bellamy, L. Shaw, J. Alder, A. Shorrocks, R. Lea, S. Birks, M. Burnet, G. Pilkington, J. D. Bruch, J. Ho, C. Watts, S. J. Price, S. Camp, V. Apostolopoulos, A. Mehta, F. Roncaroli, D. Nandi, B. Clark, M. Mackinnon, N. MacLeod, W. Stewart, A. Chalmers, A. Cole, G. Hanna, K. Bailie, D. Conkey, J. Harney, C. Darlow, S. Chapman, L. Mohsen, S. Price, L. Donovan, H. Dyer, H. Lord, K. Fletcher, R. das Nair, J. MacNiven, S. Basu, P. Byrne, L. Glancz, G. Critchley, M. Grech-Sollars, D. Saunders, K. Phipps, J. Clayden, C. Clark, A. Greco, S. Acquati, S. Marino, S. Hammouche, S. P. Wilkins, T. Smith, A. Brodbelt, S. Clark, A. H. L. Wong, P. Eldridge, J. O. Farah, J. Bruch, G. Lamb, S. Smith, A. James, M. Glegg, T. Jeffcote, S. Boulos, P. Robbins, N. Knuckey, A. Banigo, A. R. Brodbelt, M. D. Jenkinson, J. N. Jeyapalan, M. A. Mumin, T. Forshew, A. R. Lawson, R. G. Tatevossian, T. S. Jacques, D. Sheer, J. Kilday, K. Wright, S. Leavy, J. Lowe, E. Schwalbe, S. Clifford, R. Gilbertson, B. Coyle, R. Grundy, P. Kinsella, M. Clynes, V. Amberger-Murphy, N. Barron, S. R. Lambert, D. Jones, D. Pearson, I. Ichimura, V. Collins, L. Steele, P. Sinha, P. Chumas, J. Tyler, D. Ogawa, E. Chiocca, M. DeLay, A. Bronisz, M. Nowicki, J. Godlewski, S. Lawler, M. K. Lee, M. Javadpour, P. Abel, T. Dawson, B. Lea, C. S.-K. Lim, P. L. Grundy, M. Pendleton, A. Williamson, A. Merve, X. Zhang, S. Miller, H. A. Rogers, P. Lyon, V. Rand, M. Adamowicz-Brice, S. C. Clifford, J. T. Hayden, S. Dyer, S. Pfister, A. Korshunov, M.-A. Brundler, R. G. Grundy, M. Nankivell, P. Mulvenna, R. Barton, P. Wilson, C. Faivre-Finn, C. Pugh, R. Langley, D. Ngoga, D. Tennant, A. Williams, P. Moss, G. Cruickshank, K. Owusu-Agyemang, S. Bell, J. St.George, S. G. Piccirillo, S. Qadri, E. Pirola, M. Jenkinson, R. Rahman, C. Rahman, D. MacArthur, F. Rose, K. Shakesheff, C. Carroll, P. Watson, M. Hawkins, H. Spoudeas, D. Walker, T. Holland, H. Ring, A. Rooney, S. McNamara, M. Fraser, R. Rampling, A. Carson, R. Grant, J. Royds, S. Al Nadaf, A. Ahn, Y.-J. Chen, A. Wiles, D. Jellinek, A. Braithwaite, B. Baguley, M. MacFarlane, N. Hung, T. Slatter, S. Rusbridge, N. Walmsley, S. Griffiths, P. Wilford, J. Rees, D. Ryan, P. Liu, S. Galavotti, M. Shaked-Rabi, E. Tulchinsky, S. Brandner, P. Salomoni, A. Schulte, H. S. Gunther, S. Zapf, S. Riethdorf, M. Westphal, K. Lamszus, S. K. Selvanathan, H. J. Salminen, S. Setua, M. E. Welland, M. Shevtsov, W. Khachatryan, A. Kim, K. Samochernych, A. Pozdnyakov, I. V. Guzhova, I. V. Romanova, B. Margulis, J. Barrow, D. Macarthur, A. Long, Z. Maherally, J. R. Smith, L. Dickson, S. Prabhu, F. Harris, T. J. Snape, M. Sussman, S. Wilne, W. Whitehouse, G. Chow, J.-F. Liu, T. Snape, A. Karakoula, F. Rowther, T. Warr, A. Zisakis, V. Varsos, A. Panteli, O. Karypidou, A. Zampethanis, A. Fotovati, S. Abu-Ali, P.-S. Wang, L. Deleyrolle, C. Lee, J. Triscott, J. Y. Chen, S. Franciosi, Y. Nakamura, Y. Sugita, T. Uchiumi, M. Kuwano, B. R. Leavitt, S. K. Singh, A. Jury, H. Wakimoto, B. A. Reynolds, C. J. Pallen, S. E. Dunn, S. Shepherd, S. Scott, D. Bowyer, L. Wallace, B. Hacking, R. Jena, J. Gillard, M. Verraeult, B. Reynolds, C. Dunham, M. Bally, J. Hukin, S. Singhal, S. Singh, S. Dunn

Publikováno v: Neuro-Oncology. 13:ii1-ii14

INTRODUCTION: Substituted indoles and related structures have been shown to exhibit potent anticancer activity against breast cancer cell lines. Here, the effects of structurally similar substituted indoles against the human glial cancer cell lines,

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1fd03645d5059bcd6cdb359145b1432b
https://doi.org/10.1093/neuonc/nor144

Assessment of 123I-FIAU imaging of herpes simplex viral gene expression in the treatment of glioma

Autor: Donald M. Hadley, S M Brown, Sally L. Pimlott, Alice Nicol, J Owens, R. Rampling, Vakis Papanastassiou, Mary F. Dempsey, James Patterson, David J. Wyper

Publikováno v: Nuclear Medicine Communications. 27:611-617

Herpes simplex virus 1716 (HSV1716), a selectively replication competent mutant of HSV1, is under investigation as an oncolytic viral therapy in human malignant glioma. As with similar therapies, a technique for measurement of viral replication and d

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1ce12939c63fb1a6e15f72d7d8cd95b3
https://doi.org/10.1097/00006231-200608000-00003

HSV1716 injection into the brain adjacent to tumour following surgical resection of high-grade glioma: safety data and long-term survival

Autor: V Papanastassiou, S M Brown, Donald M. Hadley, S Harrow, Russell D. Petty, R Mabbs, J Harland, R Rampling, James Patterson, M Fraser

Publikováno v: Gene Therapy. 11:1648-1658

Following standard treatment, the prognosis remains poor in patients with high-grade glioma and new therapies are urgently required. Herpes simplex virus 1716 (HSV1716) is an ICP34.5 null mutant that is selectively replication competent and shown to

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::41dce7892fe32c727d4b5ab641f4d6f0
https://doi.org/10.1038/sj.gt.3302289

Multicenter phase II trial of temozolomide in patients with glioblastoma multiforme at first relapse

Autor: R. Rampling, B. A. Zonnenberg, Roger Henriksson, Sara L. Zaknoen, J. J. Heimans, Luc Dirix, Michael Brada, David R. Macdonald, N. Yue, Jose Bravo-Marques, Roger Stupp, Janet M. Bruner, Pierre Yves Dietrich, Khê Hoang-Xuan, S. Rao, M. Dugan

Publikováno v: Annals of Oncology. 12:259-266

Multicenter phase II trial of temozolomide in patients with glioblastoma multiforme at first relapse. Background: Recurrent glioblastoma multiforme (GBM) is resistant to most therapeutic endeavors, with low response rates and survival rarely exceedin

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::532e453b682f361be3ad027564119125
https://doi.org/10.1023/a:1008382516636

Toxicity evaluation of replication-competent herpes simplex virus (ICP 34.5 null mutant 1716) in patients with recurrent malignant glioma

Autor: V Papanastassiou, James A. R. Nicoll, J Harland, Garth Cruickshank, E A McKie, Donald M. Hadley, R Mabbs, R. Rampling, M Brown, David Brennan, Alasdair Roderick Maclean, Russell D. Petty

Publikováno v: Gene Therapy. 7:859-866

The herpes simplex virus (HSV) ICP34.5 null mutant 1716 replicates selectively in actively dividing cells and has been proposed as a potential treatment for cancer, particularly brain tumours. We present a clinical study to evaluate the safety of 171

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::84996e6616153257978f879a9472fbc8
https://doi.org/10.1038/sj.gt.3301184