Zobrazeno 1 - 10
of 1 206
pro vyhledávání: '"R, Pritchard"'
Autor:
Varda Lev-Ram, Sakina Palida Lemieux, Thomas J. Deerinck, Eric A. Bushong, Alex J. Perez, Denise R. Pritchard, Brandon H. Toyama, Sung Kyu R. Park, Daniel B. McClatchy, Jeffrey N. Savas, Michael Whitney, Stephen R. Adams, Mark H. Ellisman, John Yates, Roger Y. Tsien
Publikováno v:
Cells, Vol 13, Iss 19, p 1627 (2024)
Perineuronal nets (PNNs), a specialized form of extra cellular matrix (ECM), surround numerous neurons in the CNS and allow synaptic connectivity through holes in its structure. We hypothesize that PNNs serve as gatekeepers that guard and protect syn
Externí odkaz:
https://doaj.org/article/237cdaba9f744535b374e53f56520619
Publikováno v:
PLoS ONE, Vol 19, Iss 8, p e0306929 (2024)
IntroductionResidents of rural regions may have higher and unique suicide risks. Newfoundland and Labrador (NL) is a Canadian province replete with rural regions. Despite an abundance of rural suicide research, heterogeneity in rural regions may prec
Externí odkaz:
https://doaj.org/article/4bc739a760e747b29a8ed7418d29968c
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-13 (2022)
Context specificity confounds genetic analysis and prevents reproducible genome engineering. Here, the authors report a pan-CRISPR analysis of specificity in mammalian cells and identify ultra-compact sgRNA subsets for genome-scale screens.
Externí odkaz:
https://doaj.org/article/385d48492ec449398682d3f780f164a4
Publikováno v:
Genome Medicine, Vol 13, Iss 1, Pp 1-12 (2021)
Abstract Background Advances in cancer biology are increasingly dependent on integration of heterogeneous datasets. Large-scale efforts have systematically mapped many aspects of cancer cell biology; however, it remains challenging for individual sci
Externí odkaz:
https://doaj.org/article/a0f2840a60b5410fa39f4aa6d003a892
Modified Hederagenin Derivatives Demonstrate Ex Vivo Anthelmintic Activity against Fasciola hepatica
Autor:
Anand Chakroborty, Deiniol R. Pritchard, Marc E. Bouillon, Anna Cervi, Rolf Kraehenbuehl, Charlotte Wild, Caroline Fenn, Peter Holdsworth, Colin Capner, Gilda Padalino, Josephine E. Forde-Thomas, Joseph Payne, Brendan G. Smith, Maggie Fisher, Martina Lahmann, Mark S. Baird, Karl F. Hoffmann
Publikováno v:
Pharmaceutics, Vol 15, Iss 7, p 1869 (2023)
Infection with Fasciola hepatica (liver fluke) causes fasciolosis (or fascioliasis) and poses a considerable economic as well as welfare burden to both the agricultural and animal health sectors. Here, we explore the ex vivo anthelmintic potential of
Externí odkaz:
https://doaj.org/article/6e8ca26b7c334320af200daf96523567
Autor:
Thu Nguyen-Anh Tran, Nathan B. Wikle, Emmy Albert, Haider Inam, Emily Strong, Karel Brinda, Scott M. Leighow, Fuhan Yang, Sajid Hossain, Justin R. Pritchard, Philip Chan, William P. Hanage, Ephraim M. Hanks, Maciej F. Boni
Publikováno v:
BMC Medicine, Vol 19, Iss 1, Pp 1-14 (2021)
Abstract Background When three SARS-CoV-2 vaccines came to market in Europe and North America in the winter of 2020–2021, distribution networks were in a race against a major epidemiological wave of SARS-CoV-2 that began in autumn 2020. Rapid and o
Externí odkaz:
https://doaj.org/article/cb937e87c69747779b6d269f47db0b01
Autor:
Haider Inam, Ivan Sokirniy, Yiyun Rao, Anushka Shah, Farnaz Naeemikia, Edward O'Brien, Cheng Dong, David M. McCandlish, Justin R. Pritchard
Publikováno v:
iScience, Vol 24, Iss 11, Pp 103343- (2021)
Summary: Genomic data can facilitate personalized treatment decisions by enabling therapeutic hypotheses in individual patients. Mutual exclusivity has been an empirically useful signal for identifying activating mutations that respond to single agen
Externí odkaz:
https://doaj.org/article/f98a7049c703493fbae9b06d38862432
Publikováno v:
mSystems, Vol 6, Iss 4 (2021)
ABSTRACT Pathogen population dynamics during infection are critical determinants of infection susceptibility and define patterns of dissemination. However, deciphering these dynamics, particularly founding population sizes in host organs and patterns
Externí odkaz:
https://doaj.org/article/c27ed0e94cfe4cc0856dce06c62a0142
Autor:
Lee, T. S., Li, I., Peric, B., Saw, R. P. M., Duprat, J. P., Bertolli, E., Spillane, J. B., van Leeuwen, B. L., Moncrieff, M., Sommariva, A., Allan, C. P., de Wilt, J. H. W., Jones, R. Pritchard-, Geh, J. L. C., Howle, J. R., Spillane, A. J.
Publikováno v:
Annals of Surgical Oncology: An Oncology Journal for Surgeons; Jun2024, Vol. 31 Issue 6, p4061-4070, 10p
Publikováno v:
Cell Reports, Vol 30, Iss 12, Pp 3951-3963.e4 (2020)
Summary: Rationally designing drugs that last longer in the face of biological evolution is a critical objective of drug discovery. However, this goal is thwarted by the diversity and stochasticity of evolutionary trajectories that drive uncertainty
Externí odkaz:
https://doaj.org/article/4b1b504584ba4c028c270886dafe7cbd