Zobrazeno 1 - 10
of 13
pro vyhledávání: '"R, Pentel P"'
Autor:
Bethany Crouse, Shannon M. Miller, Peter Muelken, Linda Hicks, Jennifer R. Vigliaturo, Cheryl L. Marker, Alonso G. P. Guedes, Paul R. Pentel, Jay T. Evans, Mark G. LeSage, Marco Pravetoni
Publikováno v:
npj Vaccines, Vol 8, Iss 1, Pp 1-17 (2023)
Abstract Opioid use disorders (OUD) and overdose are public health threats worldwide. Widespread access to highly potent illicit synthetic opioids such as fentanyl is driving the recent rise in fatal overdoses. Vaccines containing fentanyl-based hapt
Externí odkaz:
https://doaj.org/article/84711b1689474c11879e5e0dec9e620c
Autor:
Michael D Raleigh, Nicola Beltraminelli, Stephanie Fallot, Mark G LeSage, Amy Saykao, Paul R Pentel, Steve Fuller, Thomas Thisted, Zuzanna Biesova, Stephen Horrigan, Darryl Sampey, Bin Zhou, Matthew W Kalnik
Publikováno v:
PLoS ONE, Vol 16, Iss 7, p e0254247 (2021)
Use of nicotine-specific monoclonal antibodies (mAbs) to sequester and reduce nicotine distribution to brain has been proposed as a therapeutic approach to treat nicotine addiction (the basis of tobacco use disorder). A series of monoclonal antibodie
Externí odkaz:
https://doaj.org/article/20970bf6715646829279dd4d4d1ec7c3
Autor:
Paul R. Pentel, Michael D. Raleigh, Mark G. LeSage, Thomas Thisted, Stephen Horrigan, Zuzana Biesova, Matthew W. Kalnik
Publikováno v:
BMC Biotechnology, Vol 18, Iss 1, Pp 1-14 (2018)
Abstract Background The bacterial nicotine-degrading enzyme NicA2 isolated from P. putida was studied to assess its potential use in the treatment of tobacco dependence. Results Rats were pretreated with varying i.v. doses of NicA2, followed by i.v.
Externí odkaz:
https://doaj.org/article/a0e3cd1965a54648bfdb8c93d6f253a0
Autor:
M D Raleigh, S J Peterson, M Laudenbach, F Baruffaldi, F I Carroll, S D Comer, H A Navarro, T L Langston, S P Runyon, S Winston, M Pravetoni, P R Pentel
Publikováno v:
PLoS ONE, Vol 12, Iss 12, p e0184876 (2017)
Among vaccines aimed at treating substance use disorders, those targeting opioids present several unique medication development challenges. 1) Opioid overdose is a common complication of abuse, so it is desirable for an opioid vaccine to block the to
Externí odkaz:
https://doaj.org/article/3b2e7ab5a7434204b22b8fab42f5d495
Autor:
Andrew C Harris, Mark G LeSage, David Shelley, Jennifer L Perry, Paul R Pentel, S Michael Owens
Publikováno v:
PLoS ONE, Vol 10, Iss 9, p e0138959 (2015)
Externí odkaz:
https://doaj.org/article/4f8a764aa0714531a0964963584adb07
Autor:
Andrew C Harris, Mark G LeSage, David Shelley, Jennifer L Perry, Paul R Pentel, S Michael Owens
Publikováno v:
PLoS ONE, Vol 10, Iss 3, p e0118787 (2015)
Passive immunization with monoclonal antibodies (mAbs) against (+)-methamphetamine (METH) is being evaluated for the treatment of METH addiction. A human/mouse chimeric form of the murine anti-METH mAb7F9 has entered clinical trials. This study exami
Externí odkaz:
https://doaj.org/article/dc8054b2511442b08a2ff0d28b49e3cb
Publikováno v:
PLoS ONE, Vol 9, Iss 7, p e101807 (2014)
Prescription opioid abuse is an increasing public health concern in the USA. A vaccine comprising a hapten (OXY) conjugated to the carrier protein keyhole limpet hemocyanin (OXY-KLH) has been shown to attenuate the antinociceptive effects of oxycodon
Externí odkaz:
https://doaj.org/article/e792f4c0f63f4c43828c992676d71a13
Autor:
Marco Pravetoni, Jeffrey S Vervacke, Mark D Distefano, Ashli M Tucker, Megan Laudenbach, Paul R Pentel
Publikováno v:
PLoS ONE, Vol 9, Iss 5, p e96547 (2014)
Vaccination against the highly abused prescription opioid oxycodone has shown pre-clinical efficacy for blocking oxycodone effects. The current study further evaluated a candidate vaccine composed of oxycodone derivatized at the C6 position (6OXY) co
Externí odkaz:
https://doaj.org/article/b8256fba9b734f5d99f64be212c48f5c
Pharmacokinetic correlates of the effects of a heroin vaccine on heroin self-administration in rats.
Publikováno v:
PLoS ONE, Vol 9, Iss 12, p e115696 (2014)
The purpose of this study was to evaluate the effects of a morphine-conjugate vaccine (M-KLH) on the acquisition, maintenance, and reinstatement of heroin self-administration (HSA) in rats, and on heroin and metabolite distribution during heroin admi
Externí odkaz:
https://doaj.org/article/44010c46b64445e99a8ef851a13563ec
Publikováno v:
PLoS ONE, Vol 8, Iss 12, p e82557 (2013)
Structurally distinct nicotine immunogens can elicit independent antibody responses against nicotine when administered concurrently. Co-administering different nicotine immunogens together as a multivalent vaccine could be a useful way to generate hi
Externí odkaz:
https://doaj.org/article/26680373daf44c25bdc0224908867ad2