Zobrazeno 1 - 10
of 442
pro vyhledávání: '"R, Palmeri"'
Autor:
Joseph R. Palmeri, Brianna M. Lax, Joshua M. Peters, Lauren Duhamel, Jordan A. Stinson, Luciano Santollani, Emi A. Lutz, William Pinney, Bryan D. Bryson, K. Dane Wittrup
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-19 (2024)
Abstract Although co-stimulation of T cells with agonist antibodies targeting 4-1BB (CD137) improves antitumor immune responses in preclinical studies, clinical success has been limited by on-target, off-tumor activity. Here, we report the developmen
Externí odkaz:
https://doaj.org/article/8e65e3d9cba14ba3930a59f163a199fe
Autor:
Emi A Lutz, K Dane Wittrup, Joseph R Palmeri, Brianna M Lax, Josh M Peters, Lauren Duhamel, Jordan A Stinson, Luciano Santollani, William Pinney, Bryan D Bryson
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 11, Iss Suppl 1 (2023)
Externí odkaz:
https://doaj.org/article/1d4f4929a5304e66974b9d6a359dc8a4
Autor:
Allison Sheen, Yash Agarwal, Keith M. Cheah, Sarah C. Cowles, Jordan A. Stinson, Joseph R. Palmeri, Hadley D. Sikes, K. Dane Wittrup
Publikováno v:
Redox Biology, Vol 64, Iss , Pp 102766- (2023)
Catalase is an antioxidant enzyme that catalyzes the rapid conversion of hydrogen peroxide to water and oxygen. Use of catalase as a cancer therapeutic has been proposed to reduce oxidative stress and hypoxia in the tumor microenvironment, both activ
Externí odkaz:
https://doaj.org/article/bdc02fa1657a4226b9e43defbfbf2f40
Autor:
Noor Momin, Joseph R. Palmeri, Emi A. Lutz, Noor Jailkhani, Howard Mak, Anthony Tabet, Magnolia M. Chinn, Byong H. Kang, Virginia Spanoudaki, Richard O. Hynes, K. Dane Wittrup
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-13 (2022)
Understanding the pharmacokinetics of locally-injected drugs could aid in the design of immunotherapies to maximize their therapeutic effect. Here, by evaluating different IL-2 fusion proteins, the authors show that molecular weight and matrix bindin
Externí odkaz:
https://doaj.org/article/29c0b5b17b1041eaaa47f6822400abb3
Autor:
Sarah C. Cowles, Allison Sheen, Luciano Santollani, Emi A. Lutz, Brianna M. Lax, Joseph R. Palmeri, Gordon J. Freeman, K. Dane Wittrup
Publikováno v:
mAbs, Vol 14, Iss 1 (2022)
Monoclonal antibodies targeting the programmed cell death protein 1 (PD-1) remain the most prevalent cancer immunotherapy both as a monotherapy and in combination with additional therapies. Despite the extensive success of anti-PD-1 monoclonal antibo
Externí odkaz:
https://doaj.org/article/a3566e931b5d476ea29616b10d00f10c
Publikováno v:
IEEE Open Journal of Antennas and Propagation, Vol 2, Pp 269-280 (2021)
We propose an innovative approach to the phase retrieval of 2-D discrete complex signals. The solution strategy profitably exploits some fundamental results available for the phase retrieval of one-dimensional discrete signals by following a simple y
Externí odkaz:
https://doaj.org/article/134e71c45901468ca860a4da0379b629
Akademický článek
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K zobrazení výsledku je třeba se přihlásit.
Autor:
Joseph R. Palmeri, Brianna M. Lax, Joshua M. Peters, Lauren Duhamel, Jordan A. Stinson, Luciano Santollani, Emi A. Lutz, William Pinney, Bryan D. Bryson, K. Dane Wittrup
Although co-stimulation of T cells with agonist antibodies targeting 4-1BB (CD137) improves antitumor immune responses in preclinical studies, clinical development has been hampered by on-target, off-tumor toxicity. Here, we report the development of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7c9a26a29bffbde5f9ff8ba4bf52371d
https://doi.org/10.1101/2023.01.30.526116
https://doi.org/10.1101/2023.01.30.526116
Akademický článek
Tento výsledek nelze pro nepřihlášené uživatele zobrazit.
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K zobrazení výsledku je třeba se přihlásit.
Autor:
Emi A. Lutz, Yash Agarwal, Noor Momin, Sarah C. Cowles, Joseph R. Palmeri, Ellen Duong, Vladlena Hornet, Allison Sheen, Brianna M. Lax, Adrienne M. Rothschilds, Darrell J. Irvine, Stefani Spranger, K. Dane Wittrup
Publikováno v:
Proceedings of the National Academy of Sciences. 119
Effective antitumor immunity in mice requires activation of the type I interferon (IFN) response pathway. IFNα and IFNβ therapies have proven promising in humans, but suffer from limited efficacy and high toxicity. Intratumoral IFN retention amelio
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3f7d4f5c144fec877bd5b917769ca413
https://doi.org/10.1073/pnas.2205983119
https://doi.org/10.1073/pnas.2205983119