Role of Tim4 in the regulation of ABCA1+ adipose tissue macrophages and post-prandial cholesterol levels

Autor: M. S. Magalhaes, P. Smith, J. R. Portman, L. H. Jackson-Jones, C. C. Bain, P. Ramachandran, Z. Michalidou, R. H. Stimson, M. R. Dweck, L. Denby, N. C. Henderson, S. J. Jenkins, C. Bénézech

Publikováno v: Nature Communications, Vol 12, Iss 1, Pp 1-15 (2021)

Diverse macrophage subsets are found in adipose tissue where they regulate its physiology. Here, the authors used single-cell RNA sequencing to analyse the effect of post-prandial lipids on adipose tissue macrophages and identify Tim4 as a regulator

Externí odkaz: https://doaj.org/article/39a4cc25e8ac438eaf00455de7457431

Static in vitro digestion model adapted to the general older adult population: an INFOGEST international consensus

Autor: O. Menard, U. Lesmes, C. S. Shani-Levi, A. Araiza Calahorra, A. Lavoisier, M. Morzel, A. Rieder, G. Feron, S. Nebbia, L. Mashiah, A. Andres, G. Bornhorst, F. Carrière, L. Egger, S. Gwala, A. Heredia, B. Kirkhus, A. Macierzanka, R. Portman, I. Recio, V. Santé-Lhoutellier, C. Tournier, A. Sarkar, A. Brodkorb, A. Mackie, D. Dupont

Publikováno v: Food and Function
Food and Function, 2023, 14 (10), pp.4569-4582. ⟨10.1039/D3FO00535F⟩

This article is part of the themed collection: Food & Function HOT Articles 2023.; International audience; Understanding the mechanisms of food digestion is of paramount importance to determine the effect foods have on human health. Significant knowl

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::73f4d6b7e6f23056490a14fbf44e89a1
https://doi.org/10.1039/d3fo00535f

Role of Tim4 in the regulation of ABCA1+ adipose tissue macrophages and post-prandial cholesterol levels

Autor: Roland H Stimson, Neil Henderson, Marc R. Dweck, Cécile Bénézech, Zoi Michalidou, Calum C. Bain, Stephen J. Jenkins, Prakash Ramachandran, Laura Denby, Lucy H. Jackson-Jones, Marlene Magalhaes, Jordan R. Portman, Pete Smith

Publikováno v: Nature Communications, Vol 12, Iss 1, Pp 1-15 (2021)
Nature Communications
Magalhaes, M S, Smith, P, Portman, J, Jackson-Jones, L H, Bain, C C, Ramachandran, P, Michailidou, Z, Stimson, R H, Dweck, M R, Denby, L, Henderson, N C, Jenkins, S J & Benezech, C 2021, ' Role of Tim4 in the regulation of ABCA1+ adipose tissue macrophages and post-prandial cholesterol levels ', Nature Communications . https://doi.org/10.1038/s41467-021-24684-7

Dyslipidemia is a main driver of cardiovascular diseases. The ability of macrophages to scavenge excess lipids implicate them as mediators in this process and understanding the mechanisms underlying macrophage lipid metabolism is key to the developme

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::11712ff8dd85c40f46ba080f7304e8b2
https://doaj.org/article/39a4cc25e8ac438eaf00455de7457431

Resolving the fibrotic niche of human liver cirrhosis at single cell level

Autor: Mirjana Efremova, Ross Dobie, Jonathan A. Fallowfield, Prakash Ramachandran, Stephen J. Wigmore, John P. Iredale, Ewen M Harrison, Kylie P. Matchett, John C. Marioni, David R. Mole, Christopher J. Weston, John A. Marwick, John R. Wilson-Kanamori, Roser Vento-Tormo, Philip N. Newsome, Sarah A. Teichmann, Neil C. Henderson, Neil O. Carragher, Richard S Taylor, Jordan R. Portman, Elena Dora, N T Luu, Frank Tacke, Chris P. Ponting, Jeffrey W. Pollard, Beth E. P. Henderson, Timothy J. Kendall, M Brice

Publikováno v: Nature
Ramachandran, P, Dobie, R, Wilson-Kanamori, J R, Dora, E F, Henderson, B E P, Luu, N T, Portman, J R, Matchett, K P, Brice, M, Marwick, J A, Taylor, R S, Efremova, M, Vento-Tormo, R, Carragher, N O, Kendall, T J, Fallowfield, J A, Harrison, E M, Mole, D J, Wigmore, S J, Newsome, P N, Weston, C J, Iredale, J P, Tacke, F, Pollard, J W, Ponting, C P, Marioni, J C, Teichmann, S A & Henderson, N C 2019, ' Resolving the fibrotic niche of human liver cirrhosis at single-cell level ', Nature, vol. 575, no. 7783, pp. 512–518 . https://doi.org/10.1038/s41586-019-1631-3

Liver cirrhosis is a major cause of death worldwide and is characterized by extensive fibrosis. There are currently no effective antifibrotic therapies available. To obtain a better understanding of the cellular and molecular mechanisms involved in d

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dd3362c457a2a6d54f3fadf6498190b2
http://europepmc.org/articles/PMC6876711

Deciphering Mesenchymal Drivers of Human Dupuytren’s Disease at Single-Cell Level

Autor: Ahsan R. Akram, Jordan R. Portman, Prakash Ramachandran, Laura J. Kitto, Li Yenn Yong, Neil C. Henderson, Dyana Markose, Beth E. P. Henderson, John R. Wilson-Kanamori, Dominique Davidson, Sadaf Sohrabi, Mariana Beltran, Christopher C. West, Ross Dobie

Publikováno v: Dobie, R, West, C C, Henderson, B E, Wilson-Kanamori, J R, Markose, D, Kitto, L J, Portman, J R, Beltran, M, Sohrabi, S, Akram, A R, Ramachandran, P, Yong, L Y, Davidson, D & Henderson, N C 2022, ' Deciphering mesenchymal drivers of human Dupuytren's disease at single-cell level ', Journal of Investigative Dermatology, vol. 142, no. 1, pp. 114-123.e8 . https://doi.org/10.1016/j.jid.2021.05.030

Dupuytren's disease (DD) is a common, progressive fibroproliferative disease affecting the palmar fascia of the hands, causing fingers to irreversibly flex towards the palm with significant loss of function. Surgical treatments are limited, therefore

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::44a3ce9f9c27e568af826cbf5c9f1d83
https://doi.org/10.1016/j.jid.2021.05.030