Zobrazeno 1 - 10
of 47
pro vyhledávání: '"R, Oliyai"'
Autor:
M. N. Arimilli, J. P. Shaw, R. Oliyai, Choung U. Kim, K. C. Cundy, A. Mulato, J. Dougherty, N. Bischofberger
Publikováno v:
Antiviral Chemistry and Chemotherapy. 8:557-564
Potentially orally bioavailable prodrugs of the antiretroviral agent 9-[2-(phosphonomethoxy)propyl]adenine (PMPA) were evaluated. Alkyl methyl carbamates were synthesized by alkylation of PMPA with the corresponding alkyl chloromethyl carbonate and N
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::53e68a6effe6683ad11d9e7d4f958a75
https://doi.org/10.1177/095632029700800610
https://doi.org/10.1177/095632029700800610
Akademický článek
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Tenofovir, a novel nucleotide analog, belongs to the class of acyclic nucleoside phosphonates. Tenofovir is phosphorylated in situ to the virologically active tenofovir diphosphate. Tenofovir diphosphate inhibits human immunodeficiency virus (HIV-1 a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::abd6019fc44e588134935fc3e97ea2e8
https://doi.org/10.1016/b0-08-045044-x/00289-3
https://doi.org/10.1016/b0-08-045044-x/00289-3
Publikováno v:
Pharmaceutical research. 18(2)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::cc543ae9eba223aaca23660c8177d75d
https://pubmed.ncbi.nlm.nih.gov/11405296
https://pubmed.ncbi.nlm.nih.gov/11405296
Publikováno v:
Pharmaceutical research. 17(9)
The chemical stability and product(s) distribution of adefovir dipivoxil (ADV) was examined in the presence of soluble and insoluble carbonate salts.Chemical stability of ADV in the solid state at 60 degrees C/30% RH was examined. Stability was also
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::bfee956e389980682d9ff6827a6894c2
https://pubmed.ncbi.nlm.nih.gov/11087042
https://pubmed.ncbi.nlm.nih.gov/11087042
Publikováno v:
Pharmaceutical research. 16(11)
The chemical, enzymatic, and biological stabilities and physical properties of a series of salicylate and aryl ester prodrugs of the antiviral agent, cyclic HPMPC, were evaluated to support the selection of a lead compound for clinical development.Ch
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::f9d36370ce783346408ef67c9e7a8d84
https://pubmed.ncbi.nlm.nih.gov/10571273
https://pubmed.ncbi.nlm.nih.gov/10571273
Publikováno v:
Pharmaceutical research. 14(12)
A series of prodrugs designed to enhance the oral bioavailability of the antiretroviral agent 9-[(R)-2-(phosphonomethoxy)propyl]adenine (PMPA; 1) have been synthesized, including a bis-(acyloxymethyl) ester 2 and a series of bis-(alkoxycarbonyloxymet
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::d18324ef72e7fd0f716dad948303bc84
https://pubmed.ncbi.nlm.nih.gov/9453075
https://pubmed.ncbi.nlm.nih.gov/9453075
Publikováno v:
Pharmaceutical research. 12(3)
The chemistry associated with the process of N,O-acyl migration was explored in both cyclic and linear peptides under aqueous acid conditions. The importance of backbone cyclization and N-methylation of the peptide bond on the kinetics of N,O-acyl mi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::0ad39c5f9d61edf5776be309f32ecfa5
https://pubmed.ncbi.nlm.nih.gov/7617515
https://pubmed.ncbi.nlm.nih.gov/7617515
Publikováno v:
Pharmaceutical research. 10(9)
Phosphoryloxymethyl carbonates and carbamates of the type R1R2X-CO-O-CH2-O-PO3(-2) (X = O or N) were evaluated as potentially novel water-soluble collapsible prodrugs for alcohols and amines. These were prepared by reaction of alpha-chloromethyl chlo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::1eb7a77ed8bb880c1ef7a150476e630b
https://pubmed.ncbi.nlm.nih.gov/8234176
https://pubmed.ncbi.nlm.nih.gov/8234176
Autor:
R, Oliyai, V J, Stella
Publikováno v:
Pharmaceutical research. 9(5)
The kinetics of isomerization of cyclosporin A to isocyclosporin A were studied in various nonaqueous solvents as a function of temperature and added methanesulfonic acid. The rate of isomerization was found to be acid-catalyzed over the acid concent
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::f6042e466a61501d702f524451da6027
https://pubmed.ncbi.nlm.nih.gov/1608891
https://pubmed.ncbi.nlm.nih.gov/1608891