Zobrazeno 1 - 10
of 469
pro vyhledávání: '"R, O'Keefe"'
Autor:
Yong Yean Kim, Berkley E. Gryder, Ranuka Sinniah, Megan L. Peach, Jack F. Shern, Abdalla Abdelmaksoud, Silvia Pomella, Girma M. Woldemichael, Benjamin Z. Stanton, David Milewski, Joseph J. Barchi, John S. Schneekloth, Raj Chari, Joshua T. Kowalczyk, Shilpa R. Shenoy, Jason R. Evans, Young K. Song, Chaoyu Wang, Xinyu Wen, Hsien-Chao Chou, Vineela Gangalapudi, Dominic Esposito, Jane Jones, Lauren Procter, Maura O’Neill, Lisa M. Jenkins, Nadya I. Tarasova, Jun S. Wei, James B. McMahon, Barry R. O’Keefe, Robert G. Hawley, Javed Khan
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-19 (2024)
Abstract Fusion-positive rhabdomyosarcoma (FP-RMS) is an aggressive pediatric sarcoma driven primarily by the PAX3-FOXO1 fusion oncogene, for which therapies targeting PAX3-FOXO1 are lacking. Here, we screen 62,643 compounds using an engineered cell
Externí odkaz:
https://doaj.org/article/62fcc583cb83489ca474d4e078b73633
Autor:
Kenya DeBarros, Mahfuz Khan, Morgan Coleman, Vincent C. Bond, Virginia Floyd, Erick Gbodossou, Amad Diop, Lauren R. H. Krumpe, Barry R. O’Keefe, Michael D. Powell
Publikováno v:
Viruses, Vol 16, Iss 9, p 1433 (2024)
MoMo30 is an antiviral protein isolated from aqueous extracts of Momordica balsamina L. (Senegalese bitter melon). Previously, we demonstrated MoMo30’s antiviral activity against HIV-1. Here, we explore whether MoMo30 has antiviral activity against
Externí odkaz:
https://doaj.org/article/6a84d8389db9421eb40115bf1581ae06
Autor:
Saidanxia Amuti, Yohei Saito, Shuichi Fukuyoshi, Katsunori Miyake, David J. Newman, Barry R. O’Keefe, Kuo-Hsiung Lee, Kyoko Nakagawa-Goto
Publikováno v:
Molecules, Vol 29, Iss 3, p 651 (2024)
Eight vilasinin-class limonoids, including the unusually chlorinated rubescins K–M (1–3), the 2,3-epoxylated rubescin N (4), and rubescins O–R (5–8), were newly isolated from Trichilia rubescens. The structures of the isolated compounds were
Externí odkaz:
https://doaj.org/article/73427dc785014662bb22d080535fb349
Autor:
Julia Krushkal, Simarjeet Negi, Laura M. Yee, Jason R. Evans, Tanja Grkovic, Alida Palmisano, Jianwen Fang, Hari Sankaran, Lisa M. McShane, Yingdong Zhao, Barry R. O'Keefe
Publikováno v:
Molecular Oncology, Vol 15, Iss 2, Pp 381-406 (2021)
Natural products remain a significant source of anticancer chemotherapeutics. The search for targeted drugs for cancer treatment includes consideration of natural products, which may provide new opportunities for antitumor cytotoxicity as single agen
Externí odkaz:
https://doaj.org/article/4721b276f0d848a6b0da39b8d59f04a3
Publikováno v:
Journal of Medical Radiation Sciences, Vol 67, Iss 2, Pp 102-110 (2020)
Abstract Aim This study seeks to document the imaging series used in contemporary Australian practice for imaging the augmented breast, with a secondary focus on differences in practice and opinion between BreastScreen Australia and diagnostic imagin
Externí odkaz:
https://doaj.org/article/cb08ccfa718a47428e3bfab22c16c508
Autor:
Natalia Teleshova, Marla J Keller, José A Fernández Romero, Barbara A Friedland, George W Creasy, Marlena G Plagianos, Laurie Ray, Patrick Barnable, Larisa Kizima, Aixa Rodriguez, Nadjet Cornejal, Claudia Melo, Gearoff Cruz Rodriguez, Sampurna Mukhopadhyay, Giulia Calenda, Shweta U Sinkar, Thierry Bonnaire, Asa Wesenberg, Shimin Zhang, Kyle Kleinbeck, Kenneth Palmer, Mohcine Alami, Barry R O'Keefe, Patrick Gillevet, Hong Hur, Yupu Liang, Gabriela Santone, Raina N Fichorova, Tamara Kalir, Thomas M Zydowsky
Publikováno v:
PLoS ONE, Vol 17, Iss 1, p e0261775 (2022)
HIV pre-exposure prophylaxis (PrEP) is dominated by clinical therapeutic antiretroviral (ARV) drugs. Griffithsin (GRFT) is a non-ARV lectin with potent anti-HIV activity. GRFT's preclinical safety, lack of systemic absorption after vaginal administra
Externí odkaz:
https://doaj.org/article/71d1f80746cd4044a9318e97651b89ec
Autor:
Shayan G. Borhani, Max Z. Levine, Lauren H. Krumpe, Jennifer Wilson, Curtis J. Henrich, Barry R. O’Keefe, Donald Lo, G. Sitta Sittampalam, Alexander G. Godfrey, R. Dwayne Lunsford, Venkata Mangalampalli, Dingyin Tao, Christopher A. LeClair, Aaron Thole, Douglas Frey, James Swartz, Govind Rao
Publikováno v:
bioRxiv
This study describes the cell-free biomanufacturing of a broad-spectrum antiviral protein, griffithsin (GRFT) such that it can be produced with consistent purity and potency in less than 24 hours. We demonstrate GRFT production using two independent
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::84542effbec6bea138fdb5f6cf3364cb
https://doi.org/10.1016/j.nbt.2023.04.003
https://doi.org/10.1016/j.nbt.2023.04.003
Autor:
Brice A. P. Wilson, Ning Li, Juliana A. Martinez Fiesco, Masoumeh Dalilian, Dongdong Wang, Emily A. Smith, Antony Wamiru, Rohan Shah, Ekaterina I. Goncharova, John A. Beutler, Tanja Grkovic, Ping Zhang, Barry R. O’Keefe
Publikováno v:
ACS Pharmacology & Translational Science. 6:633-650
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::304996b7e53aa21cbce68dfb3e0ac41b
https://doi.org/10.1021/acsptsci.3c00010
https://doi.org/10.1021/acsptsci.3c00010
Autor:
Jason R. Evans, Rhone K. Akee, Shaurya Chanana, Grant D. McConachie, Christopher C. Thornburg, Tanja Grkovic, Barry R. O’Keefe
Publikováno v:
ACS Omega. 8:9250-9256
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8cb752bdd174dd369b0183be521102d4
https://doi.org/10.1021/acsomega.2c07416
https://doi.org/10.1021/acsomega.2c07416
Autor:
Punya Shrivastava-Ranjan, Michael K. Lo, Payel Chatterjee, Mike Flint, Stuart T. Nichol, Joel M. Montgomery, Barry R. O'Keefe, Christina F. Spiropoulou
Publikováno v:
Frontiers in Cellular and Infection Microbiology, Vol 10 (2020)
Andes virus (ANDV) and Sin Nombre virus (SNV), highly pathogenic hantaviruses, cause hantavirus pulmonary syndrome in the Americas. Currently no therapeutics are approved for use against these infections. Griffithsin (GRFT) is a high-mannose oligosac
Externí odkaz:
https://doaj.org/article/7f404e9381c2404eba7fb33c6ff7c192