Zobrazeno 1 - 10
of 1 713
pro vyhledávání: '"R, Nilsson"'
Autor:
Marco Losa, Marc Emmenegger, Pierre De Rossi, Patrick M Schürch, Tetiana Serdiuk, Niccolò Pengo, Danaëlle Capron, Dimitri Bieli, Niklas Bargenda, Niels J Rupp, Manfredi C Carta, Karl J Frontzek, Veronika Lysenko, Regina R Reimann, Petra Schwarz, Mario Nuvolone, Gunilla T Westermark, K Peter R Nilsson, Magdalini Polymenidou, Alexandre PA Theocharides, Simone Hornemann, Paola Picotti, Adriano Aguzzi
Publikováno v:
EMBO Molecular Medicine, Vol 16, Iss 9, Pp 2024-2042 (2024)
Abstract Extracellularly released molecular inflammasome assemblies -ASC specks- cross-seed Aβ amyloid in Alzheimer’s disease. Here we show that ASC governs the extent of inflammation-induced amyloid A (AA) amyloidosis, a systemic disease caused b
Externí odkaz:
https://doaj.org/article/361701b3ccf5457e8ccf997a37e06f01
Autor:
Theodore J. Zwang, Eric del Sastre, Nina Wolf, Nancy Ruiz-Uribe, Benjamin Woost, Zachary Hoglund, Zhanyun Fan, Joshua Bailey, Lois Nfor, Luc Buée, K. Peter R. Nilsson, Bradley T. Hyman, Rachel E. Bennett
Publikováno v:
Cell Reports, Vol 43, Iss 8, Pp 114574- (2024)
Summary: A prevailing hypothesis is that neurofibrillary tangles play a causal role in driving cognitive decline in Alzheimer’s disease (AD) because tangles correlate anatomically with areas that undergo neuronal loss. We used two-photon longitudin
Externí odkaz:
https://doaj.org/article/10cc1819ed864e588cd728901f3c62be
Autor:
Cristina Nuñez-Diaz, Emelie Andersson, Nina Schultz, Dovilė Pocevičiūtė, Oskar Hansson, The Netherlands Brain Bank, K Peter R. Nilsson, Malin Wennström
Publikováno v:
Alzheimer’s Research & Therapy, Vol 16, Iss 1, Pp 1-12 (2024)
Abstract Background Amyloid beta (Aβ) deposits and hyperphosphorylated tau (p-tau) accumulation have been identified in the retina of Alzheimer’s disease (AD) patients and transgenic AD mice. Previous studies have shown that retinal microglia engu
Externí odkaz:
https://doaj.org/article/27397dde590844f6a269713b5b3e9bdf
Autor:
Maria Calvo-Rodriguez, Elizabeth K. Kharitonova, Austin C. Snyder, Steven S. Hou, Maria Virtudes Sanchez-Mico, Sudeshna Das, Zhanyun Fan, Hamid Shirani, K. Peter R. Nilsson, Alberto Serrano-Pozo, Brian J. Bacskai
Publikováno v:
Molecular Neurodegeneration, Vol 19, Iss 1, Pp 1-18 (2024)
Abstract Background Reactive oxidative stress is a critical player in the amyloid beta (Aβ) toxicity that contributes to neurodegeneration in Alzheimer’s disease (AD). Damaged mitochondria are one of the main sources of reactive oxygen species and
Externí odkaz:
https://doaj.org/article/831a14a43be94b0caad5a381475bab71
Publikováno v:
Nuclear Materials and Energy, Vol 37, Iss , Pp 101559- (2023)
Physical sputtering and its dependence on crystal orientation is well-known, but crystallinity of the target is neither commonly considered in simulations nor when publishing experimental values for its yield. Due to the recent development of detecto
Externí odkaz:
https://doaj.org/article/72ec59f4baa24d36bf8e5ab4f0360af2
Autor:
Patricia Aguilar-Calvo, Adela Malik, Daniel R Sandoval, Christopher Barback, Christina D Orrù, Heidi G Standke, Olivia R Thomas, Chrissa A Dwyer, Donald P Pizzo, Jaidev Bapat, Katrin Soldau, Ryotaro Ogawa, Mckenzie B Riley, K Peter R Nilsson, Allison Kraus, Byron Caughey, Jeffrey J Iliff, David R Vera, Jeffrey D Esko, Christina J Sigurdson
Publikováno v:
PLoS Pathogens, Vol 19, Iss 9, p e1011487 (2023)
Select prion diseases are characterized by widespread cerebral plaque-like deposits of amyloid fibrils enriched in heparan sulfate (HS), a abundant extracellular matrix component. HS facilitates fibril formation in vitro, yet how HS impacts fibrillar
Externí odkaz:
https://doaj.org/article/c83e6fca89c54c42855f3b68597d0988
Autor:
Yennie K. Bredin, Laura L. Hess, Andressa B. Scabin, Micah Dunthorn, Torbjørn Haugaasen, Carlos A. Peres, Henrik R. Nilsson, Alexandre Antonelli, Camila D. Ritter
Publikováno v:
Environmental DNA, Vol 4, Iss 3, Pp 533-548 (2022)
Abstract Amazonia encompasses extensive forests in areas that are periodically inundated by overflowing rivers. The inundation depth and duration vary according to the slope of the terrain and distance to major water bodies. This creates a flooding g
Externí odkaz:
https://doaj.org/article/bf2dfc77572b46e392622694fb9412e4
Autor:
Malin Wennström, Shorena Janelidze, K. Peter R. Nilsson, The Netherlands Brain Bank, Geidy E. Serrano, Thomas G. Beach, Jeffrey L. Dage, Oskar Hansson
Publikováno v:
Acta Neuropathologica Communications, Vol 10, Iss 1, Pp 1-12 (2022)
Abstract Recent studies highlight phosphorylated tau (p-tau) at threonine tau 217 (p-tau217) as a new promising plasma biomarker for pathological changes implicated in Alzheimer’s disease (AD), but the specific brain pathological events related to
Externí odkaz:
https://doaj.org/article/3e4b283386d94852a888c6c906dc00ef
Autor:
Daniel Kirschenbaum, Ehsan Dadgar‐Kiani, Francesca Catto, Fabian F Voigt, Chiara Trevisan, Oliver Bichsel, Hamid Shirani, K Peter R Nilsson, Karl J Frontzek, Paolo Paganetti, Fritjof Helmchen, Jin Hyung Lee, Adriano Aguzzi
Publikováno v:
EMBO Molecular Medicine, Vol 15, Iss 1, Pp n/a-n/a (2023)
Abstract Many efforts targeting amyloid‐β (Aβ) plaques for the treatment of Alzheimer's Disease thus far have resulted in failures during clinical trials. Regional and temporal heterogeneity of efficacy and dependence on plaque maturity may have
Externí odkaz:
https://doaj.org/article/b22aabc15970409aa99a43cfa57a5c79
Autor:
Alejandro Ruiz-Riquelme, Alison Mao, Marim M. Barghash, Heather H. C. Lau, Erica Stuart, Gabor G. Kovacs, K. Peter R. Nilsson, Paul E. Fraser, Gerold Schmitt-Ulms, Joel C. Watts
Publikováno v:
Acta Neuropathologica Communications, Vol 9, Iss 1, Pp 1-19 (2021)
Abstract When injected into genetically modified mice, aggregates of the amyloid-β (Aβ) peptide from the brains of Alzheimer’s disease (AD) patients or transgenic AD mouse models seed cerebral Aβ deposition in a prion-like fashion. Within the br
Externí odkaz:
https://doaj.org/article/311ee78e40194926b8b50a33d61a9ceb