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pro vyhledávání: '"R, Mank"'
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Autor:
John F. Thompson, Patrice M. Milos, Amy R. Mank-Seymour, Jodi Richmond, Gregory R. Warnes, Jennifer M. Reynolds, Linda S. Wood, Yu-Ti Fan
Publikováno v:
American Heart Journal. 152:1116-1122
Background Reduction of drug-induced adverse events may be achievable through a better understanding of the underlying causes of such events. Identifying phenotypes and genotypes that allow event prediction would provide greater safety margins for ne
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::202e2103c50f3ee09cfc4668315dfcd4
https://doi.org/10.1016/j.ahj.2006.08.020
https://doi.org/10.1016/j.ahj.2006.08.020
Autor:
Patrice M. Milos, Zhuoqian Sun, John F. Thompson, David B. Lloyd, Jason S. Cordes, Amy R. Mank-Seymour, Jun Zhou, Jodi Richmond
Publikováno v:
Journal of Molecular and Cellular Cardiology. 37:1031-1039
Various drugs are reported to prolong the QT-interval on the surface ECG, thereby increasing the risk of developing a potentially fatal arrhythmia known as Torsades de Pointes (TdP). TdP case reports for these drugs have often been associated with ri
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c49bca3fbc39aeffe061582401d60ccb
https://doi.org/10.1016/j.yjmcc.2004.09.001
https://doi.org/10.1016/j.yjmcc.2004.09.001
Autor:
John F. Thompson, Kathryn L. Durham, Patrice M. Milos, Albert B. Seymour, Amy R. Mank-Seymour
Publikováno v:
Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids. 1636:40-46
Endothelial lipase (LIPG) is the latest addition to the triglyceride lipase family of genes that includes pancreatic lipase (PL), hepatic lipase (HL), and lipoprotein lipase (LPL). These lipolytic enzymes demonstrate both triglyceride lipase as well
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7f18737d3ef0e9d32fbfe7d31ee4a733
https://doi.org/10.1016/j.bbalip.2003.12.001
https://doi.org/10.1016/j.bbalip.2003.12.001
Autor:
Lei Xiao, Celano Paul, Constance A. Griffin, Amy R. Mank, Ethylin Wang Jabs, Robert A. Casero, Anita L. Hawkins
Publikováno v:
Biochemical and Biophysical Research Communications. 187:1493-1502
The super induction of spermidine/spermine N 1 -acetyltransferase (SSAT), has been implicated in the cytotoxic response of human solid tumors to the bis(ethyl)polyamines. The SSAT response is a phenotype specific response and is modulated at the leve
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9fe11232f536ac51b7c8f06de981b1f3
https://doi.org/10.1016/0006-291x(92)90471-v
https://doi.org/10.1016/0006-291x(92)90471-v
Publikováno v:
Clinical cancer research : an official journal of the American Association for Cancer Research. 4(8)
The expression of the polyamine catabolic enzyme, spermidine/spermine N1-acetyltransferase (SSAT), has been associated with tumor sensitivity to antitumor polyamine analogues. In the sensitive cell types the level of SSAT is greatly induced by these
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::e4782558a4e407169d978d135726290e
https://pubmed.ncbi.nlm.nih.gov/9717831
https://pubmed.ncbi.nlm.nih.gov/9717831
Publikováno v:
Cancer chemotherapy and pharmacology. 36(1)
Three unsymmetrically substituted polyamine analogues demonstrate significant and selective antitumor effects. Each of the analoguesN 1-ethyl-N 11-propargyl-4,8-diazaundecane (PENSpm),N 1-ethyl-N 11-(cyclobutyl)methyl-4,8-diazaundecane (CBENSpm), and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4c406389f5412406f56fffa671479394
https://pubmed.ncbi.nlm.nih.gov/7720179
https://pubmed.ncbi.nlm.nih.gov/7720179
Autor:
Patrick M. Woster, Charles Preuss, Edward E. West, Nella C. Bieszk, Robert A. Casero, Nada H. Saab, Amy R. Mank
Publikováno v:
Journal of medicinal chemistry. 36(20)
Spermidine/spermine-N1-acetyltransferase (SSAT), the rate-limiting step in polyamine catabolism, is critical for the interconversion and modulation of cellular polyamines. Inhibitor-initiated induction of this enzyme also appears to correlate with th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b8504185b09ce1b4c89eec2e9b0c02ff
https://pubmed.ncbi.nlm.nih.gov/8411017
https://pubmed.ncbi.nlm.nih.gov/8411017
Publikováno v:
Cancer research. 53(9)
Previous studies have documented differential sensitivity of human lung cancer and melanoma cell lines to the cytotoxic effects of N1, N12-bis(ethyl)spermine (BESpm). We show here that BESpm can significantly inhibit the growth of six human breast ca
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::5d1df3dd4601e6cd69cc225b2de46b5a
https://pubmed.ncbi.nlm.nih.gov/8481909
https://pubmed.ncbi.nlm.nih.gov/8481909
Publikováno v:
Cancer research. 52(19)
Our previous results from a limited number of cell lines have suggested that the bis(ethyl)polyamine analogues exert a phenotype-specific response in human lung cancer cells. In the present study, we have extended this work to analyze the response of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::798e0616b9e2de7103310057125c871f
https://pubmed.ncbi.nlm.nih.gov/1327507
https://pubmed.ncbi.nlm.nih.gov/1327507