Zobrazeno 1 - 10
of 1 813
pro vyhledávání: '"R, Malcolm"'
Autor:
Kim R. Blasdell, Richard J. Ploeg, Emma C. Hobbs, Stephen Muhi, Sarah J. Riddell, Alexandra Cunneen, Michael L. Kelly, Kate Maynard, Tess R. Malcolm, Md. Tanjir Islam, Victoria Boyd, Timothy P. Stinear, Sacha J. Pidot, Eugene Athan, Daniel P. O’Brien
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-12 (2024)
Abstract Buruli ulcer (BU) is a necrotizing disease of skin and soft tissue caused by the bacterium Mycobacterium ulcerans (MU). In Australia, where the disease is emerging in new geographic areas and human case numbers are increasing, native possum
Externí odkaz:
https://doaj.org/article/bb97b88c1e6a4174bf8856af982849ed
Autor:
Alina L. Capatina, Jodie R. Malcolm, Jack Stenning, Rachael L. Moore, Katherine S. Bridge, William J. Brackenbury, Andrew N. Holding
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 12 (2024)
The events that control breast cancer progression and metastasis are complex and intertwined. Hypoxia plays a key role both in oncogenic transformation and in fueling the metastatic potential of breast cancer cells. Here we review the impact of hypox
Externí odkaz:
https://doaj.org/article/f6a8d132a2184bfd98fff60b790f10b2
Autor:
Carlo Giannangelo, Matthew P Challis, Ghizal Siddiqui, Rebecca Edgar, Tess R Malcolm, Chaille T Webb, Nyssa Drinkwater, Natalie Vinh, Christopher Macraild, Natalie Counihan, Sandra Duffy, Sergio Wittlin, Shane M Devine, Vicky M Avery, Tania De Koning-Ward, Peter Scammells, Sheena McGowan, Darren J Creek
Publikováno v:
eLife, Vol 13 (2024)
New antimalarial drug candidates that act via novel mechanisms are urgently needed to combat malaria drug resistance. Here, we describe the multi-omic chemical validation of Plasmodium M1 alanyl metalloaminopeptidase as an attractive drug target usin
Externí odkaz:
https://doaj.org/article/332f337244e8411285174e5b2343498f
Autor:
Rebecca C. S. Edgar, Tess R. Malcolm, Ghizal Siddiqui, Carlo Giannangelo, Natalie A. Counihan, Matthew Challis, Sandra Duffy, Mrittika Chowdhury, Jutta Marfurt, Madeline Dans, Grennady Wirjanata, Rintis Noviyanti, Kajal Daware, Chathura D. Suraweera, Ric N. Price, Sergio Wittlin, Vicky M. Avery, Nyssa Drinkwater, Susan A. Charman, Darren J. Creek, Tania F. de Koning-Ward, Peter J. Scammells, Sheena McGowan
Publikováno v:
mBio, Vol 15, Iss 6 (2024)
ABSTRACT To combat the global burden of malaria, development of new drugs to replace or complement current therapies is urgently required. Here, we show that the compound MMV1557817 is a selective, nanomolar inhibitor of both Plasmodium falciparum an
Externí odkaz:
https://doaj.org/article/2d940180a1bd41efa98e153bebf7c041