Zobrazeno 1 - 10
of 31
pro vyhledávání: '"R, Lucek"'
Publikováno v:
Genetic Epidemiology. 17:S503-S507
A recently developed approach that employs artificial neural networks (ANNs) was applied to the simulated data set to identify sets of marker loci involved in disease etiology. In this implementation, ANNs are trained to predict the disease state (ou
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::44cb2a7d33ca4fe480e6407ce74d01da
https://doi.org/10.1002/gepi.1370170781
https://doi.org/10.1002/gepi.1370170781
Autor:
Jurg Ott, Paul R. Lucek
Publikováno v:
Genetic Epidemiology. 14:1101-1106
Neural networks are capable of simultaneously analyzing multiple loci at one time in order to identify patterns of loci involved in complex traits. © 1997 Wiley-Liss, Inc.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2ba13f5dd5141f46f7622c2f289c9a51
https://doi.org/10.1002/(sici)1098-2272(1997)14:6<1101::aid-gepi90>3.0.co
https://doi.org/10.1002/(sici)1098-2272(1997)14:6<1101::aid-gepi90>3.0.co
Publikováno v:
Genetic epidemiology. 17
A recently developed approach that employs artificial neural networks (ANNs) was applied to the simulated data set to identify sets of marker loci involved in disease etiology. In this implementation, ANNs are trained to predict the disease state (ou
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::79d9aa9b8edd1ad630e2c7f556cd4441
https://pubmed.ncbi.nlm.nih.gov/10597483
https://pubmed.ncbi.nlm.nih.gov/10597483
Publikováno v:
Human heredity. 48(5)
Complex traits are generally taken to be under the influence of multiple genes, which may interact with each other to confer susceptibility to disease. Statistical methods in current use for localizing such genes essentially work under single-gene mo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e6fe1aef687dde1622de3110b1585cb8
https://pubmed.ncbi.nlm.nih.gov/9748698
https://pubmed.ncbi.nlm.nih.gov/9748698
Autor:
Paul R. Lucek, Jurg Ott
Publikováno v:
Recent Results in Cancer Research ISBN: 9783642468728
The lod score method for localizing mendelian disease genes in human genetics is reviewed. Current ways of applying this technique to hypothesized genes underlying complex traits are discussed. In contrast to these parametric methods, allele-sharing
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ca7c920500ed9eadda733ac8e230400b
https://doi.org/10.1007/978-3-642-46870-4_19
https://doi.org/10.1007/978-3-642-46870-4_19
Autor:
P R, Lucek, J, Ott
Publikováno v:
Genetic epidemiology. 14(6)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::721c84cfe2dec2ae17ce447edc100094
https://pubmed.ncbi.nlm.nih.gov/9433631
https://pubmed.ncbi.nlm.nih.gov/9433631
Publikováno v:
American journal of medical genetics. 59(2)
In order to study genetic aspects in multicase families, 89 amyotrophic lateral sclerosis (ALS) and 214 Parkinson disease (PD) kindreds were analyzed in parallel studies. Obligate gene-carriers were identified as described previously [Chatkupt et al.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::45fdba9848c4f737b20c150e5ede82ca
https://pubmed.ncbi.nlm.nih.gov/8588576
https://pubmed.ncbi.nlm.nih.gov/8588576
Publikováno v:
American journal of medical genetics. 44(4)
Fifty families (491 individuals in 137 sibships) with more than one living case of isolated, nonsyndromic spina bifida (SB) were analyzed genetically. There were twice as many gene-carrier females (56) as gene-carrier males (28) (P < 0.005). This was
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a3d3b8bb7952cc6d4d2968ec032ef939
https://pubmed.ncbi.nlm.nih.gov/1442897
https://pubmed.ncbi.nlm.nih.gov/1442897
Publikováno v:
Research communications in chemical pathology and pharmacology. 27(2)
A new, sensitive and specific radioimmunoassay (RIA) for chlordiazepoxide was used to determine concentrations of the drug in microsamples of saliva and plasma obtained from subjects following intravenous and oral administration of the drug. Saliva a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::786de1a575555eeb4ab9d4ebb47ecff3
https://pubmed.ncbi.nlm.nih.gov/7367755
https://pubmed.ncbi.nlm.nih.gov/7367755
Publikováno v:
Research communications in chemical pathology and pharmacology. 37(1)
A specific radioimmunoassay (RIA) for the determination of the new short-acting water soluble imidazo-1,4-benzodiazepine, midazolam, directly in plasma has been developed. Employing 3H-midazolam as the radioligand and a rabbit antiserum to a diazo co
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::40f3ffa7f54dd7c61d2a0e39ec140565
https://pubmed.ncbi.nlm.nih.gov/7122996
https://pubmed.ncbi.nlm.nih.gov/7122996