Zobrazeno 1 - 10
of 1 446
pro vyhledávání: '"R, Leach"'
Autor:
A. Lina Heinzke, Barbara Zdrazil, Paul D. Leeson, Robert J. Young, Axel Pahl, Herbert Waldmann, Andrew R. Leach
Publikováno v:
Scientific Data, Vol 11, Iss 1, Pp 1-9 (2024)
Abstract Providing a better understanding of what makes a compound a successful drug candidate is crucial for reducing the high attrition rates in drug discovery. Analyses of the differences between active compounds, clinical candidates and drugs req
Externí odkaz:
https://doaj.org/article/6b7b2abb2a09429392f3cc739a7e6c8c
Autor:
Kristina Edfeldt, Aled M. Edwards, Ola Engkvist, Judith Günther, Matthew Hartley, David G. Hulcoop, Andrew R. Leach, Brian D. Marsden, Amelie Menge, Leonie Misquitta, Susanne Müller, Dafydd R. Owen, Kristof T. Schütt, Nicholas Skelton, Andreas Steffen, Alexander Tropsha, Erik Vernet, Yanli Wang, James Wellnitz, Timothy M. Willson, Djork-Arné Clevert, Benjamin Haibe-Kains, Lovisa Holmberg Schiavone, Matthieu Schapira
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-10 (2024)
Abstract The Structural Genomics Consortium is an international open science research organization with a focus on accelerating early-stage drug discovery, namely hit discovery and optimization. We, as many others, believe that artificial intelligenc
Externí odkaz:
https://doaj.org/article/d7b4037ed6df47b49327448e7112d3fb
Autor:
Jonathan M. Frame, Tanya Nair, Veda Sunkara, Philip Popien, Subit Chakrabarti, Tyler Anderson, Nicholas R. Leach, Colin Doyle, Mitchell Thomas, Beth Tellman
Publikováno v:
Geophysical Research Letters, Vol 51, Iss 17, Pp n/a-n/a (2024)
Abstract Rapid and accurate maps of floods across large domains, with high temporal resolution capturing event peaks, have applications for flood forecasting and resilience, damage assessment, and parametric insurance. Satellite imagery produces inco
Externí odkaz:
https://doaj.org/article/8b428244b9f043bab25212d6540519a7
Autor:
Geneviève Trudel, Sophie Lebel, Robert L. Stephens, Caroline Séguin Leclair, Corinne R. Leach, J. Lee Westmaas
Publikováno v:
Cancer Medicine, Vol 13, Iss 11, Pp n/a-n/a (2024)
Abstract Objective Cancer‐related fatigue (CRF) and fear of cancer recurrence (FCR) are two common concerns experienced by cancer survivors. However, the relationship between these two concerns is poorly understood, and whether CRF and FCR influenc
Externí odkaz:
https://doaj.org/article/f2afb71cc95144faba1fd610d4cf980f
Autor:
Siavash Zamirpour, Yue Xuan, Zhongjie Wang, Axel Gomez, Joseph R. Leach, Dimitrios Mitsouras, David A. Saloner, Julius M. Guccione, Liang Ge, Elaine E. Tseng
Publikováno v:
International Journal of Cardiology: Heart & Vasculature, Vol 51, Iss , Pp 101375- (2024)
Objectives: Current diameter-based guidelines for ascending thoracic aortic aneurysms (aTAA) do not consistently predict risk of dissection/rupture. ATAA wall stresses may enhance risk stratification independent of diameter. The relation of wall stre
Externí odkaz:
https://doaj.org/article/0b2cdcb97f254aab8a5bda9d4d7af1a3
Autor:
Clare E. West, Mohd Karim, Maria J. Falaguera, Leo Speidel, Charlotte J. Green, Lisa Logie, Jeremy Schwartzentruber, David Ochoa, Janet M. Lord, Michael A. J. Ferguson, Chas Bountra, Graeme F. Wilkinson, Beverley Vaughan, Andrew R. Leach, Ian Dunham, Brian D. Marsden
Publikováno v:
Scientific Data, Vol 10, Iss 1, Pp 1-13 (2023)
Abstract Advancing age is the greatest risk factor for developing multiple age-related diseases. Therapeutic approaches targeting the underlying pathways of ageing, rather than individual diseases, may be an effective way to treat and prevent age-rel
Externí odkaz:
https://doaj.org/article/bd0a4e946edc4e929857d3968138af9c
Autor:
Danielle Rasooly, Gina M. Peloso, Alexandre C. Pereira, Hesam Dashti, Claudia Giambartolomei, Eleanor Wheeler, Nay Aung, Brian R. Ferolito, Maik Pietzner, Eric H. Farber-Eger, Quinn Stanton Wells, Nicole M. Kosik, Liam Gaziano, Daniel C. Posner, A. Patrícia Bento, Qin Hui, Chang Liu, Krishna Aragam, Zeyuan Wang, Brian Charest, Jennifer E. Huffman, Peter W. F. Wilson, Lawrence S. Phillips, John Whittaker, Patricia B. Munroe, Steffen E. Petersen, Kelly Cho, Andrew R. Leach, María Paula Magariños, John Michael Gaziano, VA Million Veteran Program, Claudia Langenberg, Yan V. Sun, Jacob Joseph, Juan P. Casas
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-15 (2023)
Abstract We conduct a large-scale meta-analysis of heart failure genome-wide association studies (GWAS) consisting of over 90,000 heart failure cases and more than 1 million control individuals of European ancestry to uncover novel genetic determinan
Externí odkaz:
https://doaj.org/article/121bbc31eec24459b300c8546850ced3
Autor:
Maria P. Magariños, Anna Gaulton, Eloy Félix, Tevfik Kiziloren, Ricardo Arcila, Tudor I. Oprea, Andrew R. Leach
Publikováno v:
PeerJ, Vol 11, p e15153 (2023)
The patent literature is a potentially valuable source of bioactivity data. In this article we describe a process to prioritise 3.7 million life science relevant patents obtained from the SureChEMBL database (https://www.surechembl.org/), according t
Externí odkaz:
https://doaj.org/article/5dbd917e301f45c7a2da3d708bdd1b1a
Publikováno v:
Frontiers in Cardiovascular Medicine, Vol 10 (2023)
Externí odkaz:
https://doaj.org/article/454b3e35d1704c90a2cba4d4389abdff
Autor:
Nicolas Bosc, Eloy Felix, Ricardo Arcila, David Mendez, Martin R. Saunders, Darren V. S. Green, Jason Ochoada, Anang A. Shelat, Eric J. Martin, Preeti Iyer, Ola Engkvist, Andreas Verras, James Duffy, Jeremy Burrows, J. Mark F. Gardner, Andrew R. Leach
Publikováno v:
Journal of Cheminformatics, Vol 13, Iss 1, Pp 1-14 (2021)
Abstract Malaria is a disease affecting hundreds of millions of people across the world, mainly in developing countries and especially in sub-Saharan Africa. It is the cause of hundreds of thousands of deaths each year and there is an ever-present ne
Externí odkaz:
https://doaj.org/article/1d37eed4555b444eb014f23ae427ad95