Výsledky vyhledávání

TNF and its receptor antibody agonist differ in mediation of cellular responses

Autor: K Totpal, R LaPushin, T Kohno, B G Darnay, B B Aggarwal

Publikováno v: The Journal of Immunology. 153:2248-2257

TNF binds to two distinct receptors designated p60 and p80. Because Abs to the p60 receptor (anti-p60) can mimic TNF, we therefore compared the cellular signaling of TNF with that of anti-p60. We demonstrate both qualitative and quantitative differen

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::30eb918cf081efbda6ab5233a84f3284
https://doi.org/10.4049/jimmunol.153.5.2248

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In vitro and in vivo antitumor effect of the anti-CD26 monoclonal antibody 1F7 on human CD30+ anaplastic large cell T-cell lymphoma Karpas 299

Autor: L, Ho, U, Aytac, L C, Stephens, K, Ohnuma, G B, Mills, K S, McKee, C, Neumann, R, LaPushin, F, Cabanillas, J L, Abbruzzese, C, Morimoto, N H, Dang

Publikováno v: Clinical cancer research : an official journal of the American Association for Cancer Research. 7(7)

CD26 is a M(r) 110,000 surface glycoprotein with diverse functional properties, including having a potentially significant role in tumor development, and antibodies to CD26 mediate pleomorphic cellular functions. In this report, we show that binding

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::494215399f01901a6bbccf3f88b16dd4
https://pubmed.ncbi.nlm.nih.gov/11448921

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Inhibition of growth-factor-induced phosphorylation and activation of protein kinase B/Akt by atypical protein kinase C in breast cancer cells

Autor: M, Mao, X, Fang, Y, Lu, R, Lapushin, R C, Bast, G B, Mills

Publikováno v: The Biochemical journal.

The protein kinase B/Akt serine/threonine kinase, located downstream of phosphoinositide 3-kinase (PI-3K), is a major regulator of cellular survival and proliferation. Atypical protein kinase C (aPKC) family members are activated by PI-3K and also co

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::0aebbfc18bf5ea6ef17cacd20bd8b241
https://pubmed.ncbi.nlm.nih.gov/11085941

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Lysophosphatidic acid prevents apoptosis in fibroblasts via G(i)-protein-mediated activation of mitogen-activated protein kinase

Autor: X, Fang, S, Yu, R, LaPushin, Y, Lu, T, Furui, L Z, Penn, D, Stokoe, J R, Erickson, R C, Bast, G B, Mills

Publikováno v: The Biochemical journal.

Lysophosphatidic acid (LPA) is a naturally occurring phospholipid with multiple biological functions. In the present study, we demonstrate that, besides its mitogenic activity, LPA is a potent survival factor, preventing serum-deprivation-induced apo

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::dc42cbcecfdfaca8d5f37ddba5b26188
https://pubmed.ncbi.nlm.nih.gov/11062066

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Overexpression of edg-2/vzg-1 induces apoptosis and anoikis in ovarian cancer cells in a lysophosphatidic acid-independent manner

Autor: T, Furui, R, LaPushin, M, Mao, H, Khan, S R, Watt, M A, Watt, Y, Lu, X, Fang, S, Tsutsui, Z H, Siddik, R C, Bast, G B, Mills

Publikováno v: Clinical cancer research : an official journal of the American Association for Cancer Research. 5(12)

Lysophosphatidic acid (LPA) is one of the major growth factors in ascites from ovarian cancer patients and appears to play an important role in proliferation, survival, and invasion of ovarian cancer cells. Recently, several groups have shown that Ed

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::59b4aff05d0ad9c6c61a2e462818a531
https://pubmed.ncbi.nlm.nih.gov/10632375

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Molecular and biologic characterization of a newly established Philadelphia-positive acute lymphoblastic leukemia cell line (Z-33) with an autocrine response to GM-CSF

Autor: Z, Estrov, M, Talpaz, S, Ku, D, Harris, R, LaPushin, C A, Koller, C, Hirsh-Ginsberg, Y, Huh, G, Yee, R, Kurzrock

Publikováno v: Leukemia. 10(9)

We have recently established a new Philadelphia chromosome (Ph1)-positive acute lymphoblastic leukemia (ALL) cell line, designated Z-33. This line has L2 morphology, ultrastructural characteristics of lymphoblasts and typical B lineage surface marker

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::d18010c624d019870a5ac6dac0c306d6
https://pubmed.ncbi.nlm.nih.gov/8751477

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Tumor necrosis factor and lymphotoxin. Qualitative and quantitative differences in the mediation of early and late cellular response

Autor: M M, Chaturvedi, R, LaPushin, B B, Aggarwal

Publikováno v: The Journal of biological chemistry. 269(20)

Tumor necrosis factor (TNF) is a 17-kDa protein produced by monocytes and a wide variety of other cell types in response to endotoxin and other cytokines. In contrast, lymphotoxin (LT) is a 25-kDa glycoprotein produced only by lymphocytes activated b

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::3ce0fe2d33727dea0a155532869582c0
https://pubmed.ncbi.nlm.nih.gov/8182064

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In vitro selection of NIH-3T3 cells for resistance to lymphotoxin induces resistance to activated macrophages and enhances tumorigenicity in vivo

Autor: K, Totpal, R, Lapushin, H N, Ananthaswamy, B B, Aggarwal

Publikováno v: Lymphokine and cytokine research. 10(5)

It is well known that expression of certain growth factors leads to tumorigenesis. However, the role of growth inhibitory molecules in this process is less certain. During the last few years several cytokines with growth inhibitory properties have be

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::6317a570444e51607594dcd0006c62a7
https://pubmed.ncbi.nlm.nih.gov/1768739

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