Zobrazeno 1 - 10
of 226
pro vyhledávání: '"R, La Harpe"'
Autor:
J. Javier Meana, Marcel Ferrer-Alcón, Jesús A. García-Sevilla, Rebeca Diez-Alarcia, M.J. García-Fuster, R. La Harpe
Publikováno v:
Neuroscience. 277:541-551
Enhanced brain apoptosis (neurons and glia) may be involved in major depression (MD) and schizophrenia (SZ), mainly through the activation of the intrinsic (mitochondrial) apoptotic pathway. In the extrinsic death pathway, pro-apoptotic Fas-associate
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::743f3d5a27edf1856c9ebf6cfd88ffb6
https://doi.org/10.1016/j.neuroscience.2014.07.027
https://doi.org/10.1016/j.neuroscience.2014.07.027
Autor:
Benito Morentin, Jesús A. García-Sevilla, R. La Harpe, Guadalupe Rivero, Luis F. Callado, Ane M. Gabilondo, J. Javier Meana
Publikováno v:
Psychopharmacology. 226:177-188
Regulator of G-protein signaling (RGS) proteins, RGS4 and RGS10, may be involved in the pathophysiology of schizophrenia. RGS4 has attracted special interest since the reports of genetic association between SNPs in RGS4 and schizophrenia. However, th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::88822fb792637cda20f6330226756bd6
https://doi.org/10.1007/s00213-012-2888-5
https://doi.org/10.1007/s00213-012-2888-5
Autor:
María Álvaro-Bartolomé, Jesús A. García-Sevilla, R. La Harpe, Luis F. Callado, J. Javier Meana
Publikováno v:
Neuroscience. 196:1-15
Cocaine induces apoptotic effects in cultured cells and in the developing brain, but the aberrant activation of cell death in the adult brain remains inconclusive, especially in humans. This postmortem human brain study examined the status of canonic
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c96d7e2f0501cefcaf5f44fa56c91b4c
https://doi.org/10.1016/j.neuroscience.2011.08.074
https://doi.org/10.1016/j.neuroscience.2011.08.074
Autor:
Jesús A. García-Sevilla, Guadalupe Rivero, M.J. García-Fuster, J. Javier Meana, Alfredo Ramos-Miguel, R. La Harpe
Publikováno v:
Neuroscience. 157:105-119
Opiate addiction is a chronic medical disorder characterized by drug tolerance and dependence, behavioral sensitization, vulnerability to compulsive relapse, and high mortality. In laboratory animals, the potential effect of opiate drugs to induce ce
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a8a23877a2950f97e882bbb6cb40056a
https://doi.org/10.1016/j.neuroscience.2008.09.002
https://doi.org/10.1016/j.neuroscience.2008.09.002
Publikováno v:
Journal of Neurochemistry. 90:220-230
Opiate addiction involves the development of chronic adaptive changes in µ-opioid receptors and associated pathways (e.g. cAMP signalling) which lead to neuronal plasticity in the brain. This study assessed the status of cAMP and mitogen-activated p
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f21d8f87fd760222f3c08a961646e0e0
https://doi.org/10.1111/j.1471-4159.2004.02473.x
https://doi.org/10.1111/j.1471-4159.2004.02473.x
Autor:
Xavier Busquets, José Guimón, Pere Ventayol, Claude Walzer, R. La Harpe, Jesús A. García-Sevilla
Publikováno v:
Scopus-Elsevier
NEUROFILAMENT (NF) proteins, the major components of the neuronal cytoskeleton, have been shown to represent previously unknown targets for the chronic effects of morphine in rats. This study was designed to evaluate the abundance of immunoreactive N
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::21a411ed43efb41d40160df182843b11
https://doi.org/10.1097/00001756-199705060-00003
https://doi.org/10.1097/00001756-199705060-00003
Autor:
R. La Harpe, W. Michiels
Publikováno v:
Sozial- und Präventivmedizin. 41:28-35
The main aim of the study is to measure the importance of alcoholism amongst alcohol intoxication (up to the Swiss legal BAC: 0.8 gr/kg) in traffic. The method used describes the characteristics of all cases of inebriety (amongst pedestrians and driv
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::eb072e529da14b26392baae7d478de65
https://doi.org/10.1007/bf01358844
https://doi.org/10.1007/bf01358844
Autor:
Franck Schürhoff, R. La Harpe, Alexandre Méary, Eladia Ballmann, Stéphane Jamain, G. Marillier, Nader Perroud, Marion Leboyer, Félicien Karege, Alain Malafosse, S. Burkhardt, Rafael Fernandez
Publikováno v:
Genes, Brain and Behavior, Vol. 9, No 5 (2010) pp. 503-511
The AKT1 gene has been associated with the genetic aetiology of schizophrenia. Following the overlap model of bipolar disorder and schizophrenia, we aimed to investigate AKT1 genetic variants and protein expression in both diseases. A total of 679 su
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3f30147d338b24f4a4d4ab8b95049da0
https://doi.org/10.1111/j.1601-183x.2010.00578.x
https://doi.org/10.1111/j.1601-183x.2010.00578.x
Autor:
R. La Harpe, J. Javier Meana, M.J. García-Fuster, A. Ramos-Miguel, Luis F. Callado, Jesús A. García-Sevilla
Publikováno v:
Neuroscience. 161(1)
Fas-associated protein with death domain (FADD) is a multifunctional protein that can induce both apoptotic and non-apoptotic actions. Recently, FADD was found downregulated in the prefrontal cortex of opiate abusers, which suggested an attenuation o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::111f61aaefa0a87988ff08f44fe227fe
https://pubmed.ncbi.nlm.nih.gov/19303913
https://pubmed.ncbi.nlm.nih.gov/19303913
Publikováno v:
Medicine, science, and the law. 46(4)
The purpose of this paper is to present the legal aspects associated with assisted suicide in Switzerland and compare them with those in other countries. Like euthanasia, assisted suicide is a subject that induces much discussion in many countries. W
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2d0573ed41e89ed691b386b1da1839a8
https://pubmed.ncbi.nlm.nih.gov/17191631
https://pubmed.ncbi.nlm.nih.gov/17191631