Zobrazeno 1 - 10
of 219
pro vyhledávání: '"R, La Harpe"'
Autor:
J. Javier Meana, Marcel Ferrer-Alcón, Jesús A. García-Sevilla, Rebeca Diez-Alarcia, M.J. García-Fuster, R. La Harpe
Publikováno v:
Neuroscience. 277:541-551
Enhanced brain apoptosis (neurons and glia) may be involved in major depression (MD) and schizophrenia (SZ), mainly through the activation of the intrinsic (mitochondrial) apoptotic pathway. In the extrinsic death pathway, pro-apoptotic Fas-associate
Autor:
Benito Morentin, Jesús A. García-Sevilla, R. La Harpe, Guadalupe Rivero, Luis F. Callado, Ane M. Gabilondo, J. Javier Meana
Publikováno v:
Psychopharmacology. 226:177-188
Regulator of G-protein signaling (RGS) proteins, RGS4 and RGS10, may be involved in the pathophysiology of schizophrenia. RGS4 has attracted special interest since the reports of genetic association between SNPs in RGS4 and schizophrenia. However, th
Autor:
María Álvaro-Bartolomé, Jesús A. García-Sevilla, R. La Harpe, Luis F. Callado, J. Javier Meana
Publikováno v:
Neuroscience. 196:1-15
Cocaine induces apoptotic effects in cultured cells and in the developing brain, but the aberrant activation of cell death in the adult brain remains inconclusive, especially in humans. This postmortem human brain study examined the status of canonic
Autor:
Jesús A. García-Sevilla, Guadalupe Rivero, M.J. García-Fuster, J. Javier Meana, Alfredo Ramos-Miguel, R. La Harpe
Publikováno v:
Neuroscience. 157:105-119
Opiate addiction is a chronic medical disorder characterized by drug tolerance and dependence, behavioral sensitization, vulnerability to compulsive relapse, and high mortality. In laboratory animals, the potential effect of opiate drugs to induce ce
Publikováno v:
Journal of Neurochemistry. 90:220-230
Opiate addiction involves the development of chronic adaptive changes in µ-opioid receptors and associated pathways (e.g. cAMP signalling) which lead to neuronal plasticity in the brain. This study assessed the status of cAMP and mitogen-activated p
Autor:
Xavier Busquets, José Guimón, Pere Ventayol, Claude Walzer, R. La Harpe, Jesús A. García-Sevilla
Publikováno v:
Scopus-Elsevier
NEUROFILAMENT (NF) proteins, the major components of the neuronal cytoskeleton, have been shown to represent previously unknown targets for the chronic effects of morphine in rats. This study was designed to evaluate the abundance of immunoreactive N
Autor:
R. La Harpe, W. Michiels
Publikováno v:
Sozial- und Präventivmedizin. 41:28-35
The main aim of the study is to measure the importance of alcoholism amongst alcohol intoxication (up to the Swiss legal BAC: 0.8 gr/kg) in traffic. The method used describes the characteristics of all cases of inebriety (amongst pedestrians and driv
Autor:
Franck Schürhoff, R. La Harpe, Alexandre Méary, Eladia Ballmann, Stéphane Jamain, G. Marillier, Nader Perroud, Marion Leboyer, Félicien Karege, Alain Malafosse, S. Burkhardt, Rafael Fernandez
Publikováno v:
Genes, Brain and Behavior, Vol. 9, No 5 (2010) pp. 503-511
The AKT1 gene has been associated with the genetic aetiology of schizophrenia. Following the overlap model of bipolar disorder and schizophrenia, we aimed to investigate AKT1 genetic variants and protein expression in both diseases. A total of 679 su
Autor:
R. La Harpe, J. Javier Meana, M.J. García-Fuster, A. Ramos-Miguel, Luis F. Callado, Jesús A. García-Sevilla
Publikováno v:
Neuroscience. 161(1)
Fas-associated protein with death domain (FADD) is a multifunctional protein that can induce both apoptotic and non-apoptotic actions. Recently, FADD was found downregulated in the prefrontal cortex of opiate abusers, which suggested an attenuation o
Publikováno v:
Medicine, science, and the law. 46(4)
The purpose of this paper is to present the legal aspects associated with assisted suicide in Switzerland and compare them with those in other countries. Like euthanasia, assisted suicide is a subject that induces much discussion in many countries. W