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Molecular architecture of the developing mouse brain

Autor: Sten Linnarsson, Alejandro Mossi Albiach, Peter Lönnerberg, Daniel Gyllborg, Lisa M. Dratva, Alessandro Furlan, Mats Nilsson, Alex R. Lederer, Kimberly Siletti, Elin Vinsland, Gioele La Manno, Anna Johnsson, Christoffer Mattsson Langseth, Irina Khven

Publikováno v: Nature. 596:92-96

The mammalian brain develops through a complex interplay of spatial cues generated by diffusible morphogens, cell–cell interactions and intrinsic genetic programs that result in probably more than a thousand distinct cell types. A complete understa

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::f9e22ef90f8bcd89a85dbe06201cd6ec
https://doi.org/10.1038/s41586-021-03775-x

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Sphingolipids control dermal fibroblast heterogeneity

Publikováno v: Science, 376(6590):eabh1623. American Association for the Advancement of Science

Human cells produce thousands of lipids that change during cell differentiation and can vary across individual cells of the same type. However, we are only starting to characterize the function of these cell-to-cell differences in lipid composition.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::110e0c2c2d1411b0740884ffa8b0473d
https://doi.org/10.1126/science.abh1623

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The emergence and promise of single-cell temporal-omics approaches

Autor: Alex R. Lederer, Gioele La Manno

Publikováno v: Current Opinion in Biotechnology. 63:70-78

Single-cell transcriptomics enables the measurement of gene expression in complex biological systems at the resolution of individual cells. Multivariate analysis of single-cell data helps describe the variation in expression accompanying cellular pro

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9d1d092985453c8a11481941ee5785ec
https://doi.org/10.1016/j.copbio.2019.12.005

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The Paf1 Complex Broadly Impacts the Transcriptome of Saccharomyces cerevisiae

Autor: Travis N. Mavrich, Alex R. Lederer, Corey Nislow, Elizabeth A Raupach, Marcie H. Warner, Mitchell A. Ellison, Miler T. Lee, Lawrence E. Heisler, Karen M. Arndt

Publikováno v: Genetics. 212:711-728

The Polymerase Associated Factor 1 complex (Paf1C) is a multifunctional regulator of eukaryotic gene expression important for the coordination of transcription with chromatin modification and post-transcriptional processes. In this study, we investig

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::ad9f2d8673930a6f70c53cbbfc2ba9f4
https://doi.org/10.1534/genetics.119.302262

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Diltiazem Does Not Prevent Postoperative Atrial Fibrillation After Thoracoscopic Lobectomy

Autor: Alexa Deemer, Franzes Anne Liongson, Nicholas Roma, Madeline R Lederer, Jill Stoltzfus, Charles T. Lee, William R. Burfeind

Publikováno v: Innovations (Philadelphia, Pa.). 16(3)

ObjectiveThoracoscopic lobectomy is associated with lower rates of adverse events compared to thoracotomy. Despite this, postoperative atrial fibrillation (POAF) occurs in at least 10% of patients. Our objective is to determine if prophylaxis with di

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::27da264a1fbffe1192a2769b36317545
https://pubmed.ncbi.nlm.nih.gov/33729854

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Molecular profiling of retinal pigment epithelial cell differentiation for therapeutic use

Autor: Sandra Petrus-Reurer, Hammurabi Bartuma, Erik Sundström, Fredrik Lanner, Aparna Bhaduri, Gioele La Manno, Belinda Pannagel, Arnold R. Kriegstein, Iyadh Douagi, Magdalena Wagner, Alex R. Lederer, Helder André, Anders Kvanta, Monica Aronsson, Laura Baqué-Vidal

Human embryonic stem cell-derived retinal pigment epithelial cells (hESC-RPE) are a promising cell source to treat age-related macular degeneration (AMD). Despite several ongoing clinical studies, detailed single cell mapping of the transient cellula

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::72512e9321e0b7813f080e16dc583792
https://doi.org/10.1101/2021.01.31.429014

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Molecular architecture of the developing mouse brain

Autor: Gioele, La Manno, Kimberly, Siletti, Alessandro, Furlan, Daniel, Gyllborg, Elin, Vinsland, Alejandro, Mossi Albiach, Christoffer, Mattsson Langseth, Irina, Khven, Alex R, Lederer, Lisa M, Dratva, Anna, Johnsson, Mats, Nilsson, Peter, Lönnerberg, Sten, Linnarsson

Publikováno v: Nature. 596(7870)

The mammalian brain develops through a complex interplay of spatial cues generated by diffusible morphogens, cell-cell interactions and intrinsic genetic programs that result in probably more than a thousand distinct cell types. A complete understand

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::8558183dd71f2c8f2335c01f1fbd8a0a
https://pubmed.ncbi.nlm.nih.gov/34321664

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Multiplexed precision genome editing with trackable genomic barcodes in yeast

Publikováno v: Nature biotechnology

Our understanding of how genotype controls phenotype is limited by the scale at which we can precisely alter the genome and assess the phenotypic consequences of each perturbation. Here we describe a CRISPR-Cas9-based method for multiplexed accurate

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d7d365cf236adff204b8bd011b1059c9
https://doi.org/10.1038/nbt.4137

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