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Autor:
Mark A. Geyer, R Kuczenski, Alexander B. Niculescu, James B. Lohr, Corey A. Ogden, Nicholas J. Schork, Martin P. Paulus, M E Rich
Publikováno v:
Molecular Psychiatry. 9:1007-1029
Identifying genes for bipolar mood disorders through classic genetics has proven difficult. Here, we present a comprehensive convergent approach that translationally integrates brain gene expression data from a relevant pharmacogenomic mouse model (i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1eb88e4bbc4ae3fa112aa372c4bef686
https://doi.org/10.1038/sj.mp.4001547
https://doi.org/10.1038/sj.mp.4001547
Autor:
R, Kuczenski, D S, Segal
Publikováno v:
The Journal of pharmacology and experimental therapeutics. 296(3)
The prescribed use of methylphenidate (Ritalin) in the treatment of attention deficit hyperactivity disorder has risen dramatically in recent years. The relative roles of dopamine, norepinephrine, and serotonin in the therapeutic action of these drug
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::8d93a571ff47409404c9fd14c0a12a9a
https://pubmed.ncbi.nlm.nih.gov/11181919
https://pubmed.ncbi.nlm.nih.gov/11181919
Publikováno v:
Synapse (New York, N.Y.). 39(2)
Although the behavioral consequences of methamphetamine (METH) abuse have been extensively documented, a more precise and thorough understanding of underlying neurobiological mechanisms still requires the use of animal models. To study these biochemi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::a66e25831abfa96d8597318dc3aab18c
https://pubmed.ncbi.nlm.nih.gov/11180503
https://pubmed.ncbi.nlm.nih.gov/11180503
Autor:
D S, Segal, R, Kuczenski
Publikováno v:
The Journal of pharmacology and experimental therapeutics. 291(1)
Our previous studies indicate that exposure of rats to an escalating-dose, multibinge pattern of amphetamine or methamphetamine administration results in a unique emergent behavioral profile and concomitant regionally specific dopamine response patte
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::a0e0343003d505a21be746f5bf3935a4
https://pubmed.ncbi.nlm.nih.gov/10490882
https://pubmed.ncbi.nlm.nih.gov/10490882
Publikováno v:
Synapse (New York, N.Y.). 31(2)
We compared the behavioral and caudate-putamen extracellular dopamine responses following intravenous (3.6 mg/kg) and subcutaneous (8 mg/kg) amphetamine administration using 2-min microdialysate sampling intervals, and doses of the drug selected to a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::a32b737af89f764f6ebec3c0c700985c
https://pubmed.ncbi.nlm.nih.gov/10024009
https://pubmed.ncbi.nlm.nih.gov/10024009
Autor:
R, Kuczenski, D S, Segal
Publikováno v:
The Journal of pharmacology and experimental therapeutics. 288(2)
The quantitative and qualitative features of the behavioral response to amphetamine-like stimulants in rats can be dissociated from the dopamine response. This dissociation is particularly evident in the temporal profiles of the extracellular dopamin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::061caa69dee8e4b02b9b7d7e832bd971
https://pubmed.ncbi.nlm.nih.gov/9918578
https://pubmed.ncbi.nlm.nih.gov/9918578
Publikováno v:
The Journal of pharmacology and experimental therapeutics. 288(2)
This study evaluated whether the caudate-putamen dopamine response that has been observed after deprenyl administration could be attributed exclusively to metabolically generated l-methamphetamine (l-MeAmp). Brain and plasma levels of deprenyl and l-
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::b017ca6ff06ed8cc908fba09a244b054
https://pubmed.ncbi.nlm.nih.gov/9918585
https://pubmed.ncbi.nlm.nih.gov/9918585
Publikováno v:
The Journal of pharmacology and experimental therapeutics. 282(2)
To further delineate amphetamine-dopamine pharmacokinetic-pharmacodynamic relationships, we examined extracellular levels of dopamine and amphetamine in caudate-putamen after the s.c. administration of 8 mg/kg amphetamine. In a parallel group of anim
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::03b242550e309cd4c11ecb8ca3dbd573
https://pubmed.ncbi.nlm.nih.gov/9262319
https://pubmed.ncbi.nlm.nih.gov/9262319