Zobrazeno 1 - 10
of 607
pro vyhledávání: '"R, Kucherlapati"'
Autor:
R. Kucherlapati
Genetic analysis of microbial systems provided us with the foundation for un derstanding gene structure, expression, and regulation. It was long felt that the ability to generate mutants and conduct genetic studies in mammalian systems would prove
The molecular pathogenesis of Noonan, Costello, and Cardio-facio-cutaneous syndromes has recently been described. All of these disorders result from an abnormal activation of the RAS-MAPK pathway. RAS-MAPK pathway activation is a common occurrence in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9251596771606693a8be7c990c2039dd
https://doi.org/10.1159/000164851
https://doi.org/10.1159/000164851
Autor:
John N. Weinstein, Bogdan Czerniak, Dean F. Bajorin, Andrew J. Mungall, Chad J. Creighton, Victor E. Reuter, Toshinori Hinoue, Xiaoping Su, Peter W. Laird, Seth P. Lerner, Donna E. Hansel, Raju R. Kucherlapati, Katherine A. Hoadley, Andrew D. Cherniack, Gordon B. Mills, David J. Kwiatkowski, Margaret B. Morgan, Joshua M. Stuart, Nikolaus Schultz, Gordon Robertson, Jaegil Kim, Brian D. Robinson, Yuexin Liu, Michael C. Ryan, Dmitry R. Gordenin, Jeffrey S. Damrauer, Rehan Akbani, Hikmat Al-Ahmadie, Wei Zhang, David J. McConkey, Steven J.M. Jones, Jonathan E. Rosenberg, William Y. Kim
Publikováno v:
Cancer Research. 75:2969-2969
In 2014, as part of The Cancer Genome Atlas (TCGA) Project, we reported molecular profiling of 131 chemotherapy-naive, muscle-invasive urothelial bladder cancers for DNA copy number variants (CNVs), somatic mutations by whole exome sequencing (WES),
Akademický článek
Tento výsledek nelze pro nepřihlášené uživatele zobrazit.
K zobrazení výsledku je třeba se přihlásit.
K zobrazení výsledku je třeba se přihlásit.
Autor:
H, Hörig, A, Wainstein, L, Long, D, Kahn, S, Soni, A, Marcus, W, Edelmann, R, Kucherlapati, H L, Kaufman
Publikováno v:
Cancer research. 61(23)
A new murine model of human colorectal cancer was generated by crossing human carcinoembryonic antigen (CEA) transgenic mice (H-2K(b)) with adenomatous polyposis coli (Apc1638N) knockout mice (H-2K(b)). The resulting hybrid mice developed gastrointes
Autor:
M, Kuraguchi, K, Yang, E, Wong, E, Avdievich, K, Fan, R D, Kolodner, M, Lipkin, A M, Brown, R, Kucherlapati, W, Edelmann
Publikováno v:
Cancer research. 61(21)
In mammalian cells, mismatch recognition has been attributed to two partially redundant heterodimeric protein complexes of MutS homologues, MSH2-MSH3 and MSH2-MSH6. We have conducted a comparative analysis of Msh3 and Msh6 deficiency in mouse intesti
Autor:
W, Yang, A, Velcich, J, Mariadason, C, Nicholas, G, Corner, M, Houston, W, Edelmann, R, Kucherlapati, P R, Holt, L H, Augenlicht
Publikováno v:
Cancer research. 61(16)
Sulindac, a nonsteroidal anti-inflammatory drug, inhibits intestinal tumorigenesis in humans and rodents. Sulindac induced complex alterations in gene expression, but only 0.1% of 8063 sequences assayed were altered similarly by the drug in rectal bi
Autor:
R, Smits, N, Hofland, W, Edelmann, M, Geugien, S, Jagmohan-Changur, C, Albuquerque, C, Breukel, R, Kucherlapati, M F, Kielman, R, Fodde
Publikováno v:
Genes, chromosomescancer. 29(3)
The APC gene, originally identified as the gene for familial adenomatous polyposis (FAP), is now considered as the true "gatekeeper" of colonic epithelial proliferation. Its main tumor suppressing activity seems to reside in the capacity to properly
Autor:
D M, Marcus, A K, Rustgi, D, Defoe, R, Kucherlapati, W, Edelmann, D, Hamasaki, G I, Liou, S B, Smith
Publikováno v:
Molecular vision. 6
In order to continue the previous morphological studies of eyes from mice with adenomatous polyposis coli (APC) gene mutation at codon 1638, we determined the ultrastructural and electrophysiologic characteristics of these eyes.Thirty-eight eyes from
Autor:
S, Bala, H, Oliver, B, Renault, K, Montgomery, S, Dutta, P, Rao, J, Houldsworth, R, Kucherlapati, X, Wang, R S, Chaganti, V V, Murty
Publikováno v:
Genes, chromosomescancer. 28(3)
Cytogenetic and molecular analyses have shown that the chromosome band 12q22 is recurrently deleted in male germ cell tumors (GCTs), indicating the presence of a candidate tumor suppressor gene (TSG) in this region. To identify the TSG, we mapped the