Zobrazeno 1 - 10
of 128
pro vyhledávání: '"R, Kirshner"'
Autor:
Min Zhu, Kara Olson, Jessica R. Kirshner, Masood Khaksar Toroghi, Hong Yan, Lauric Haber, Craig Meagher, Dina M. Flink, Srikanth R. Ambati, John D. Davis, A. Thomas DiCioccio, Eric J. Smith, Marc W. Retter
Publikováno v:
Clinical and Translational Science, Vol 15, Iss 4, Pp 954-966 (2022)
Abstract Odronextamab is a fully‐human IgG4‐based CD20xCD3 bispecific antibody that binds to CD3 on T cells and CD20 on B cells, triggering T‐cell‐mediated cytotoxicity independent of T‐cell‐receptor recognition. Adequate safety, tolerabi
Externí odkaz:
https://doaj.org/article/a445f9bfc75148d9ba23acb3770e8acf
Autor:
Lauric Haber, Kara Olson, Marcus P. Kelly, Alison Crawford, David J. DiLillo, Richard Tavaré, Erica Ullman, Shu Mao, Lauren Canova, Olga Sineshchekova, Jennifer Finney, Arpita Pawashe, Supriya Patel, Ryan McKay, Sahar Rizvi, Ermelinda Damko, Danica Chiu, Kristin Vazzana, Priyanka Ram, Katja Mohrs, Amanda D’Orvilliers, Jenny Xiao, Sosina Makonnen, Carlos Hickey, Cody Arnold, Jason Giurleo, Ya Ping Chen, Courtney Thwaites, Drew Dudgeon, Kevin Bray, Ashique Rafique, Tammy Huang, Frank Delfino, Aynur Hermann, Jessica R. Kirshner, Marc W. Retter, Robert Babb, Douglas MacDonald, Gang Chen, William C. Olson, Gavin Thurston, Samuel Davis, John C. Lin, Eric Smith
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-17 (2021)
Abstract T-cell-redirecting bispecific antibodies have emerged as a new class of therapeutic agents designed to simultaneously bind to T cells via CD3 and to tumor cells via tumor-cell-specific antigens (TSA), inducing T-cell-mediated killing of tumo
Externí odkaz:
https://doaj.org/article/13db8e3e17e043ffbbadbbb6bb988d63
Autor:
Gavin Thurston, Richard Tavare, Marcus P Kelly, Sosina Makonnen, Carlos Hickey, T Cody Arnold, Jason T Giurleo, Makenzie Danton, Christian Granados, Ishita Chatterjee, Drew Dudgeon, Marc W Retter, Dangshe Ma, William C Olson, Jessica R Kirshner
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 9, Iss 1 (2021)
Background Programmed cell death protein 1/programmed death-ligand 1 (PD-1/PD-L1) blocking antibodies including cemiplimab have generated profound clinical activity across diverse cancer types. Tumorous PD-L1 expression, as assessed by immunohistoche
Externí odkaz:
https://doaj.org/article/95ca884fb1ff45408c623ba0079af2dc
Autor:
Alison Crawford, Jessica R. Kirshner, Gavin Thurston, Eric Smith, Dangshe Ma, Jason T. Giurleo, Pamela Krueger, Sumreen Jalal, Jennifer Finney, Makenzie Danton, Priyanka Ram, Kristin Vazzana, Olulanu H. Aina, Lauric Haber, Richard Tavaré, Danica Chiu
Patients with hematologic cancers have improved outcomes after treatment with bispecific antibodies that bind to CD3 on T cells and that redirect T cells toward cancer cells. However, clinical benefit against solid tumors remains to be shown. We made
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::26c35e7d21e92f6019bfca787dcc9c83
https://doi.org/10.1158/2326-6066.c.6550329.v1
https://doi.org/10.1158/2326-6066.c.6550329.v1
Autor:
Jessica R. Kirshner, Dangshe Ma, Gavin Thurston, William C. Olson, Adam Griesemer, Akiva Mintz, Jon Popke, Lynn E. Macdonald, Andrew Murphy, Hans Gartner, Naxin Tu, Cagan Gurer, Christos A. Kyratsous, Thomas Barry, Mikhail Doubrovin, Nikunj B. Bhatt, Drew Dudgeon, Terra Potocky, Kurt H. Edelmann, Erica Ullman, Aynur Hermann, Karina Bruestle, Fanny Fredriksson, Marcus P. Kelly, Tomas C. Arnold, Carlos Hickey, Sosina Makonnen, Jason T. Giurleo, Makenzie Danton, Richard Tavaré
Assessment of immune-cell subsets within the tumor immune microenvironment is a powerful approach to better understand cancer immunotherapy responses. However, the use of biopsies to assess the tumor immune microenvironment poses challenges, includin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::63a28c1ce088d993bb73c7f8fe1e2f64
https://doi.org/10.1158/2326-6066.c.6550910.v1
https://doi.org/10.1158/2326-6066.c.6550910.v1
Autor:
Alison Crawford, Jessica R. Kirshner, Gavin Thurston, Eric Smith, Dangshe Ma, Jason T. Giurleo, Pamela Krueger, Sumreen Jalal, Jennifer Finney, Makenzie Danton, Priyanka Ram, Kristin Vazzana, Olulanu H. Aina, Lauric Haber, Richard Tavaré, Danica Chiu
Supplementary figures
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::90be1b820eb9b214932b71972d26d15a
https://doi.org/10.1158/2326-6066.22543602.v1
https://doi.org/10.1158/2326-6066.22543602.v1
Autor:
Jessica R. Kirshner, Dangshe Ma, Gavin Thurston, William C. Olson, Adam Griesemer, Akiva Mintz, Jon Popke, Lynn E. Macdonald, Andrew Murphy, Hans Gartner, Naxin Tu, Cagan Gurer, Christos A. Kyratsous, Thomas Barry, Mikhail Doubrovin, Nikunj B. Bhatt, Drew Dudgeon, Terra Potocky, Kurt H. Edelmann, Erica Ullman, Aynur Hermann, Karina Bruestle, Fanny Fredriksson, Marcus P. Kelly, Tomas C. Arnold, Carlos Hickey, Sosina Makonnen, Jason T. Giurleo, Makenzie Danton, Richard Tavaré
Supplementary Data from Immuno-PET Monitoring of Lymphocytes Using the CD8-Specific Antibody REGN5054
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bc99ef8fb49a9843c409980f336132eb
https://doi.org/10.1158/2326-6066.22545326.v1
https://doi.org/10.1158/2326-6066.22545326.v1
Autor:
Gavin Thurston, William Olson, Christopher Daly, Douglas MacDonald, Thomas Nittoli, Arthur Kunz, Ashique Rafique, Jessica R. Kirshner, Marcus P. Kelly, Joel Martin, Frank Delfino, Andres E. Perez Bay, Nithya Thambi, Julian Andreev
Proteasomal degradation inhibitors, Bortezomib and Lactacystin had little or no effect on PRLR turnover.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::41eb2f6ae3fa37e4537ad5c76a2cab15
https://doi.org/10.1158/1535-7163.22507911.v1
https://doi.org/10.1158/1535-7163.22507911.v1
Autor:
Jessica R. Kirshner, Gavin Thurston, Pamela A. Trail, Thomas Nittoli, Jason T. Giurleo, Christopher D'Souza, Arthur Kunz, Julian Andreev, Ishita Chatterjee, Terra B. Potocky, Jing Shan, Frank Delfino, Yu Wang, Sumreen Jalal, Sandra Coetzee, Sosina Makonnen, Carlos Hickey, Marcus P. Kelly
Supplementary Figures S1 - S8 as referenced in the main article
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::02543ae3f8c659cbf2d85cbb22484266
https://doi.org/10.1158/1535-7163.22503190
https://doi.org/10.1158/1535-7163.22503190
Autor:
Gavin Thurston, William Olson, Christopher Daly, Douglas MacDonald, Thomas Nittoli, Arthur Kunz, Ashique Rafique, Jessica R. Kirshner, Marcus P. Kelly, Joel Martin, Frank Delfino, Andres E. Perez Bay, Nithya Thambi, Julian Andreev
In vitro Potency of HER2 ADC, PRLR ADC and HER2xPRLRbs ADC in a Panel of Breast Cancer Cell Lines
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5e72e35383c7df743d9e49e300217e52
https://doi.org/10.1158/1535-7163.22507893
https://doi.org/10.1158/1535-7163.22507893