Validation of human telomere length multi-ancestry meta-analysis association signals identifies POP5 and KBTBD6 as human telomere length regulation genes

Autor: Rebecca Keener, Surya B. Chhetri, Carla J. Connelly, Margaret A. Taub, Matthew P. Conomos, Joshua Weinstock, Bohan Ni, Benjamin Strober, Stella Aslibekyan, Paul L. Auer, Lucas Barwick, Lewis C. Becker, John Blangero, Eugene R. Bleecker, Jennifer A. Brody, Brian E. Cade, Juan C. Celedon, Yi-Cheng Chang, L. Adrienne Cupples, Brian Custer, Barry I. Freedman, Mark T. Gladwin, Susan R. Heckbert, Lifang Hou, Marguerite R. Irvin, Carmen R. Isasi, Jill M. Johnsen, Eimear E. Kenny, Charles Kooperberg, Ryan L. Minster, Take Naseri, Satupa’itea Viali, Sergei Nekhai, Nathan Pankratz, Patricia A. Peyser, Kent D. Taylor, Marilyn J. Telen, Baojun Wu, Lisa R. Yanek, Ivana V. Yang, Christine Albert, Donna K. Arnett, Allison E. Ashley-Koch, Kathleen C. Barnes, Joshua C. Bis, Thomas W. Blackwell, Eric Boerwinkle, Esteban G. Burchard, April P. Carson, Zhanghua Chen, Yii-Der Ida Chen, Dawood Darbar, Mariza de Andrade, Patrick T. Ellinor, Myriam Fornage, Bruce D. Gelb, Frank D. Gilliland, Jiang He, Talat Islam, Stefan Kaab, Sharon L. R. Kardia, Shannon Kelly, Barbara A. Konkle, Rajesh Kumar, Ruth J. F. Loos, Fernando D. Martinez, Stephen T. McGarvey, Deborah A. Meyers, Braxton D. Mitchell, Courtney G. Montgomery, Kari E. North, Nicholette D. Palmer, Juan M. Peralta, Benjamin A. Raby, Susan Redline, Stephen S. Rich, Dan Roden, Jerome I. Rotter, Ingo Ruczinski, David Schwartz, Frank Sciurba, M. Benjamin Shoemaker, Edwin K. Silverman, Moritz F. Sinner, Nicholas L. Smith, Albert V. Smith, Hemant K. Tiwari, Ramachandran S. Vasan, Scott T. Weiss, L. Keoki Williams, Yingze Zhang, Elad Ziv, Laura M. Raffield, Alexander P. Reiner, NHLBI Trans-Omics for Precision Medicine (TOPMed) Consortium, TOPMed Hematology and Hemostasis Working Group, TOPMed Structural Variation Working Group, Marios Arvanitis, Carol W. Greider, Rasika A. Mathias, Alexis Battle

Publikováno v: Nature Communications, Vol 15, Iss 1, Pp 1-21 (2024)

Abstract Genome-wide association studies (GWAS) have become well-powered to detect loci associated with telomere length. However, no prior work has validated genes nominated by GWAS to examine their role in telomere length regulation. We conducted a

Externí odkaz: https://doaj.org/article/3e293e6c932a4a42b553d789d690044b

Neurocognitive profiles are associated with subsequent brain integrity in a sample of Hispanics/Latinos: Findings from the SOL‐INCA‐MRI study (HCHS/SOL)

Autor: Shraddha Sapkota, Pauline Maillard, Ariana M. Stickel, Wassim Tarraf, Kevin A. Gonzalez, Vladimir Ivanovic, Alejandra Morlett‐Paredes, Jianwen Cai, Carmen R. Isasi, Richard B. Lipton, Martha Daviglus, Fernando Daniel Testai, Melissa Lamar, Linda C. Gallo, Gregory A. Talavera, Christian Agudelo, Alberto R. Ramos, Hector M. González, Charles DeCarli

Publikováno v: Alzheimer’s & Dementia: Diagnosis, Assessment & Disease Monitoring, Vol 16, Iss 3, Pp n/a-n/a (2024)

Abstract The Hispanic/Latino population is one of the largest and most diverse ethnoracial groups in the United States at high risk for dementia. We examined cognitive constructs and associations with subsequent hippocampal volume (HV) and white matt

Externí odkaz: https://doaj.org/article/cd13a84f97854114bb5e5ed21dafcf73

Cardiovascular disease risk exacerbates brain aging among Hispanic/Latino adults in the SOL-INCA-MRI Study

Autor: Ariana M. Stickel, Wassim Tarraf, Kevin A. Gonzalez, Alejandra Morlett Paredes, Donglin Zeng, Jianwen Cai, Carmen R. Isasi, Robert Kaplan, Richard B. Lipton, Martha L. Daviglus, Fernando D. Testai, Melissa Lamar, Linda C. Gallo, Gregory A. Talavera, Marc D. Gellman, Alberto R. Ramos, Vladimir Ivanovic, Stephan Seiler, Hector M. González, Charles DeCarli

Publikováno v: Frontiers in Aging Neuroscience, Vol 16 (2024)

BackgroundCardiovascular disease (CVD) risk factors are highly prevalent among Hispanic/Latino adults, while the prevalence of MRI infarcts is not well-documented. We, therefore, sought to examine the relationships between CVD risk factors and infarc

Externí odkaz: https://doaj.org/article/a7449ad033f54a1abf335dc1939002ad

Characterizing cognitive profiles in diverse middle‐aged and older Hispanics/Latinos: Study of Latinos‐Investigation of Neurocognitive Aging (HCHS/SOL)

Autor: Lisa V. Graves, Wassim Tarraf, Kevin Gonzalez, Mark W. Bondi, Linda C. Gallo, Carmen R. Isasi, Martha Daviglus, Melissa Lamar, Donglin Zeng, Jianwen Cai, Hector M. González

Publikováno v: Alzheimer’s & Dementia: Diagnosis, Assessment & Disease Monitoring, Vol 16, Iss 2, Pp n/a-n/a (2024)

Abstract Introduction We investigated cognitive profiles among diverse, middle‐aged and older Hispanic/Latino adults in the Study of Latinos–Investigation of Neurocognitive Aging (SOL‐INCA) cohort using a cross‐sectional observational study d

Externí odkaz: https://doaj.org/article/75c2c47122364f5cb64294cff9c40597

Association of Unfavorable Social Determinants of Health With Stroke/Transient Ischemic Attack and Vascular Risk Factors in Hispanic/Latino Adults: Results From Hispanic Community Health Study/Study of Latinos

Autor: Gabriela Trifan, Linda C. Gallo, Melissa Lamar, Olga Garcia-Bedoya, Krista M. Perreira, Amber Pirzada, Gregory A. Talavera, Sylvia W. Smoller, Carmen R. Isasi, Jianwen Cai, Martha L. Daviglus, Fernando D. Testai

Publikováno v: Journal of Stroke, Vol 25, Iss 3, Pp 361-370 (2023)

Background and Purpose Social determinants of health (SDOH) are non-medical factors that may contribute to the development of diseases, with a higher representation in underserved populations. Our objective is to determine the association of unfavora

Externí odkaz: https://doaj.org/article/9bf42a860697427682106c6e6c69eb83