Antarctic Blue Ice Areas are hydrologically active, nutrient rich and contain microbially diverse cryoconite holes

Autor: Aga Nowak, Elisabeth Isaksson, Øyvind Sunde, Synnøve Elvevold, Håkon Sandven, Geir Moholdt, Stephen R. Hudson, Anne Urset, Arwyn Edwards, Sara M. E. Rassner, David Pearce, Børge Hamre, Andrew Hodson

Publikováno v: Communications Earth & Environment, Vol 5, Iss 1, Pp 1-13 (2024)

Abstract Antarctica is the coldest, windiest and least inhabited place on Earth. One of its most enigmatic regions is scoured by katabatic winds blue ice that covers 235,000 km2 of the Antarctic fringe. Here, we demonstrate that contrary to common be

Externí odkaz: https://doaj.org/article/fa8dccd4251a40528ce6f51311ec538d

PlmCas12e (CasX2) cleavage of CCR5: impact of guide RNA spacer length and PAM sequence on cleavage activity

Autor: David A. Armstrong, Taylor R. Hudson, Christine A. Hodge, Thomas H. Hampton, Alexandra L. Howell, Matthew S. Hayden

Publikováno v: RNA Biology, Vol 20, Iss 1, Pp 296-305 (2023)

Gene editing using CRISPR/Cas (clustered regularly interspaced palindromic repeats/CRISPR-associated) is under development as a therapeutic tool for the modification of genes in eukaryotic cells. While much effort has focused on CRISPR/Cas9 systems f

Externí odkaz: https://doaj.org/article/3092a982d9e24dcfb4b7f3197bde4b92

Neuroimaging-based classification of PTSD using data-driven computational approaches: A multisite big data study from the ENIGMA-PGC PTSD consortium

Autor: Xi Zhu, Yoojean Kim, Orren Ravid, Xiaofu He, Benjamin Suarez-Jimenez, Sigal Zilcha-Mano, Amit Lazarov, Seonjoo Lee, Chadi G. Abdallah, Michael Angstadt, Christopher L. Averill, C. Lexi Baird, Lee A. Baugh, Jennifer U. Blackford, Jessica Bomyea, Steven E. Bruce, Richard A. Bryant, Zhihong Cao, Kyle Choi, Josh Cisler, Andrew S. Cotton, Judith K. Daniels, Nicholas D. Davenport, Richard J. Davidson, Michael D. DeBellis, Emily L. Dennis, Maria Densmore, Terri deRoon-Cassini, Seth G. Disner, Wissam El Hage, Amit Etkin, Negar Fani, Kelene A. Fercho, Jacklynn Fitzgerald, Gina L. Forster, Jessie L. Frijling, Elbert Geuze, Atilla Gonenc, Evan M. Gordon, Staci Gruber, Daniel W Grupe, Jeffrey P. Guenette, Courtney C. Haswell, Ryan J. Herringa, Julia Herzog, David Bernd Hofmann, Bobak Hosseini, Anna R. Hudson, Ashley A. Huggins, Jonathan C. Ipser, Neda Jahanshad, Meilin Jia-Richards, Tanja Jovanovic, Milissa L. Kaufman, Mitzy Kennis, Anthony King, Philipp Kinzel, Saskia B.J. Koch, Inga K. Koerte, Sheri M. Koopowitz, Mayuresh S. Korgaonkar, John H. Krystal, Ruth Lanius, Christine L. Larson, Lauren A.M. Lebois, Gen Li, Israel Liberzon, Guang Ming Lu, Yifeng Luo, Vincent A. Magnotta, Antje Manthey, Adi Maron-Katz, Geoffery May, Katie McLaughlin, Sven C. Mueller, Laura Nawijn, Steven M. Nelson, Richard W.J. Neufeld, Jack B Nitschke, Erin M. O'Leary, Bunmi O. Olatunji, Miranda Olff, Matthew Peverill, K. Luan Phan, Rongfeng Qi, Yann Quidé, Ivan Rektor, Kerry Ressler, Pavel Riha, Marisa Ross, Isabelle M. Rosso, Lauren E. Salminen, Kelly Sambrook, Christian Schmahl, Martha E. Shenton, Margaret Sheridan, Chiahao Shih, Maurizio Sicorello, Anika Sierk, Alan N. Simmons, Raluca M. Simons, Jeffrey S. Simons, Scott R. Sponheim, Murray B. Stein, Dan J. Stein, Jennifer S. Stevens, Thomas Straube, Delin Sun, Jean Théberge, Paul M. Thompson, Sophia I. Thomopoulos, Nic J.A. van der Wee, Steven J.A. van der Werff, Theo G.M. van Erp, Sanne J.H. van Rooij, Mirjam van Zuiden, Tim Varkevisser, Dick J. Veltman, Robert R.J.M. Vermeiren, Henrik Walter, Li Wang, Xin Wang, Carissa Weis, Sherry Winternitz, Hong Xie, Ye Zhu, Melanie Wall, Yuval Neria, Rajendra A. Morey

Publikováno v: NeuroImage, Vol 283, Iss , Pp 120412- (2023)

Background: Recent advances in data-driven computational approaches have been helpful in devising tools to objectively diagnose psychiatric disorders. However, current machine learning studies limited to small homogeneous samples, different methodolo

Externí odkaz: https://doaj.org/article/064745d8320544298a997782e36ec231

A new approach to meteorological observations on remote polar glaciers using open-source internet of things technologies

Autor: Simon Filhol, Pierre-Marie Lefeuvre, Juan David Ibañez, John Hulth, Stephen R. Hudson, Jean-Charles Gallet, Thomas Vikhamar Schuler, John F. Burkhart

Publikováno v: Frontiers in Environmental Science, Vol 11 (2023)

Key regions of the world lack sufficient infrastructure to collect geophysical observations, often due to logistical challenges such as difficult accessibility and cost. With the advent of Internet-of-Things (IoT) technologies and low-cost electronic

Externí odkaz: https://doaj.org/article/92754652345a489dbf3ad91d09f65134

Potential Roles for the GluN2D NMDA Receptor Subunit in Schizophrenia

Autor: Chitra Vinnakota, Matthew R. Hudson, Nigel C. Jones, Suresh Sundram, Rachel A. Hill

Publikováno v: International Journal of Molecular Sciences, Vol 24, Iss 14, p 11835 (2023)

Glutamate N-methyl-D-aspartate receptor (NMDAR) hypofunction has been proposed to underlie schizophrenia symptoms. This theory arose from the observation that administration of NMDAR antagonists, which are compounds that inhibit NMDAR activity, repro

Externí odkaz: https://doaj.org/article/036f31ae68f8436dbb2b7c26171de070