Zobrazeno 1 - 10
of 50
pro vyhledávání: '"R, Houchens"'
Autor:
Lindsay N. Carpp, Ollivier Hyrien, Youyi Fong, David Benkeser, Sanne Roels, Daniel J. Stieh, Ilse Van Dromme, Griet A. Van Roey, Avi Kenny, Ying Huang, Marco Carone, Adrian B. McDermott, Christopher R. Houchens, Karen Martins, Lakshmi Jayashankar, Flora Castellino, Obrimpong Amoa-Awua, Manjula Basappa, Britta Flach, Bob C. Lin, Christopher Moore, Mursal Naisan, Muhammed Naqvi, Sandeep Narpala, Sarah O’Connell, Allen Mueller, Leo Serebryannyy, Mike Castro, Jennifer Wang, Christos J. Petropoulos, Alex Luedtke, Yiwen Lu, Chenchen Yu, Michal Juraska, Nima S. Hejazi, Daniel N. Wolfe, Jerald Sadoff, Glenda E. Gray, Beatriz Grinsztejn, Paul A. Goepfert, Linda-Gail Bekker, Aditya H. Gaur, Valdilea G. Veloso, April K. Randhawa, Michele P. Andrasik, Jenny Hendriks, Carla Truyers, An Vandebosch, Frank Struyf, Hanneke Schuitemaker, Macaya Douoguih, James G. Kublin, Lawrence Corey, Kathleen M. Neuzil, Dean Follmann, Richard A. Koup, Ruben O. Donis, Peter B. Gilbert, On behalf of the Immune Assays Team, the Coronavirus Vaccine Prevention Network (CoVPN)/ENSEMBLE Team, the United States Government (USG)/CoVPN Biostatistics Team
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-18 (2024)
Abstract Assessment of immune correlates of severe COVID-19 has been hampered by the low numbers of severe cases in COVID-19 vaccine efficacy (VE) trials. We assess neutralizing and binding antibody levels at 4 weeks post-Ad26.COV2.S vaccination as c
Externí odkaz:
https://doaj.org/article/e3fbd928bb5b421b95c9d27047187105
Autor:
Bo Zhang, Youyi Fong, Jonathan Fintzi, Eric Chu, Holly E. Janes, Avi Kenny, Marco Carone, David Benkeser, Lars W. P. van der Laan, Weiping Deng, Honghong Zhou, Xiaowei Wang, Yiwen Lu, Chenchen Yu, Bhavesh Borate, Haiyan Chen, Isabel Reeder, Lindsay N. Carpp, Christopher R. Houchens, Karen Martins, Lakshmi Jayashankar, Chuong Huynh, Carl J. Fichtenbaum, Spyros Kalams, Cynthia L. Gay, Michele P. Andrasik, James G. Kublin, Lawrence Corey, Kathleen M. Neuzil, Frances Priddy, Rituparna Das, Bethany Girard, Hana M. El Sahly, Lindsey R. Baden, Thomas Jones, Ruben O. Donis, Richard A. Koup, Peter B. Gilbert, Dean Follmann, On behalf of the United States Government (USG) COVID-19 Immune Assays Team, Moderna, Inc. Team, Coronavirus Vaccine Prevention Network (CoVPN)/Coronavirus Efficacy (COVE) Team, USG/CoVPN Biostatistics Team
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-13 (2024)
Abstract In the phase 3 Coronavirus Efficacy (COVE) trial (NCT04470427), post-dose two Ancestral Spike-specific binding (bAb) and neutralizing (nAb) antibodies were shown to be correlates of risk (CoR) and of protection against Ancestral-lineage COVI
Externí odkaz:
https://doaj.org/article/3b5ac665acef48f6bef0aa0502ebe57b
Autor:
David Benkeser, Youyi Fong, Holly E. Janes, Elizabeth J. Kelly, Ian Hirsch, Stephanie Sproule, Ann Marie Stanley, Jill Maaske, Tonya Villafana, Christopher R. Houchens, Karen Martins, Lakshmi Jayashankar, Flora Castellino, Victor Ayala, Christos J. Petropoulos, Andrew Leith, Deanne Haugaard, Bill Webb, Yiwen Lu, Chenchen Yu, Bhavesh Borate, Lars W. P. van der Laan, Nima S. Hejazi, Lindsay N. Carpp, April K. Randhawa, Michele P. Andrasik, James G. Kublin, Margaret Brewinski Isaacs, Mamodikoe Makhene, Tina Tong, Merlin L. Robb, Lawrence Corey, Kathleen M. Neuzil, Dean Follmann, Corey Hoffman, Ann R. Falsey, Magdalena Sobieszczyk, Richard A. Koup, Ruben O. Donis, Peter B. Gilbert, on behalf of the AstraZeneca AZD1222 Clinical Study Group, the Immune Assays Team, the United States Government (USG)/CoVPN Biostatistics Team
Publikováno v:
npj Vaccines, Vol 8, Iss 1, Pp 1-13 (2023)
Abstract In the phase 3 trial of the AZD1222 (ChAdOx1 nCoV-19) vaccine conducted in the U.S., Chile, and Peru, anti-spike binding IgG concentration (spike IgG) and pseudovirus 50% neutralizing antibody titer (nAb ID50) measured four weeks after two d
Externí odkaz:
https://doaj.org/article/4081698c1e354ea79e55b3bd26cbe811
Autor:
Youyi Fong, Yunda Huang, David Benkeser, Lindsay N. Carpp, Germán Áñez, Wayne Woo, Alice McGarry, Lisa M. Dunkle, Iksung Cho, Christopher R. Houchens, Karen Martins, Lakshmi Jayashankar, Flora Castellino, Christos J. Petropoulos, Andrew Leith, Deanne Haugaard, Bill Webb, Yiwen Lu, Chenchen Yu, Bhavesh Borate, Lars W. P. van der Laan, Nima S. Hejazi, April K. Randhawa, Michele P. Andrasik, James G. Kublin, Julia Hutter, Maryam Keshtkar-Jahromi, Tatiana H. Beresnev, Lawrence Corey, Kathleen M. Neuzil, Dean Follmann, Julie A. Ake, Cynthia L. Gay, Karen L. Kotloff, Richard A. Koup, Ruben O. Donis, Peter B. Gilbert, Immune Assays Team, Coronavirus Vaccine Prevention Network (CoVPN)/2019nCoV-301 Principal Investigators and Study Team, United States Government (USG)/CoVPN Biostatistics Team
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-15 (2023)
Authors have previously reported on the efficacy and safety of the recombinant spike protein nanoparticle vaccine, NVX-CoV2373, in healthy adults. In this work, they assess anti-spike binding IgG, anti-RBD binding IgG and neutralising antibody titer
Externí odkaz:
https://doaj.org/article/f3590fa9e20145b28dc93b73d492a237
Autor:
Ying Huang, Nima S. Hejazi, Bryan Blette, Lindsay N. Carpp, David Benkeser, David C. Montefiori, Adrian B. McDermott, Youyi Fong, Holly E. Janes, Weiping Deng, Honghong Zhou, Christopher R. Houchens, Karen Martins, Lakshmi Jayashankar, Britta Flach, Bob C. Lin, Sarah O’Connell, Charlene McDanal, Amanda Eaton, Marcella Sarzotti-Kelsoe, Yiwen Lu, Chenchen Yu, Avi Kenny, Marco Carone, Chuong Huynh, Jacqueline Miller, Hana M. El Sahly, Lindsey R. Baden, Lisa A. Jackson, Thomas B. Campbell, Jesse Clark, Michele P. Andrasik, James G. Kublin, Lawrence Corey, Kathleen M. Neuzil, Rolando Pajon, Dean Follmann, Ruben O. Donis, Richard A. Koup, Peter B. Gilbert, on behalf of the Immune Assays, Moderna, Inc., Coronavirus Vaccine Prevention Network (CoVPN)/Coronavirus Efficacy (COVE), United States Government (USG)/CoVPN Biostatistics Teams
Publikováno v:
Viruses, Vol 15, Iss 10, p 2029 (2023)
The COVE trial randomized participants to receive two doses of mRNA-1273 vaccine or placebo on Days 1 and 29 (D1, D29). Anti-SARS-CoV-2 Spike IgG binding antibodies (bAbs), anti-receptor binding domain IgG bAbs, 50% inhibitory dilution neutralizing a
Externí odkaz:
https://doaj.org/article/86848c63770d47f1b9459f59b793650a
Publikováno v:
Vaccines, Vol 11, Iss 6, p 1120 (2023)
Outbreaks of viral hemorrhagic fever caused by filoviruses have become more prevalent in recent years, with outbreaks of Ebola virus (EBOV), Sudan virus (SUDV), and Marburg virus (MARV) all occurring in 2022 and 2023. While licensed vaccines are now
Externí odkaz:
https://doaj.org/article/c3c3b52c6eb84d948ad63d432716d934
Autor:
Youyi Fong, Yunda Huang, David Benkeser, Lindsay N. Carpp, Germán Áñez, Wayne Woo, Alice McGarry, Lisa M. Dunkle, Iksung Cho, Christopher R. Houchens, Karen Martins, Lakshmi Jayashankar, Flora Castellino, Christos J. Petropoulos, Andrew Leith, Deanne Haugaard, Bill Webb, Yiwen Lu, Chenchen Yu, Bhavesh Borate, Lars W. P. van der Laan, Nima S. Hejazi, April K. Randhawa, Michele P. Andrasik, James G. Kublin, Julia Hutter, Maryam Keshtkar-Jahromi, Tatiana H. Beresnev, Lawrence Corey, Kathleen M. Neuzil, Dean Follmann, Julie A. Ake, Cynthia L. Gay, Karen L. Kotloff, Richard A. Koup, Ruben O. Donis, Peter B. Gilbert, Immune Assays Team, Coronavirus Vaccine Prevention Network (CoVPN)/2019nCoV-301 Principal Investigators and Study Team, United States Government (USG)/CoVPN Biostatistics Team
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-1 (2023)
Externí odkaz:
https://doaj.org/article/b85419e23d814712a753f2591916bbfa
Autor:
Peter B, Gilbert, David C, Montefiori, Adrian B, McDermott, Youyi, Fong, David, Benkeser, Weiping, Deng, Honghong, Zhou, Christopher R, Houchens, Karen, Martins, Lakshmi, Jayashankar, Flora, Castellino, Britta, Flach, Bob C, Lin, Sarah, O'Connell, Charlene, McDanal, Amanda, Eaton, Marcella, Sarzotti-Kelsoe, Yiwen, Lu, Chenchen, Yu, Bhavesh, Borate, Lars W P, van der Laan, Nima S, Hejazi, Chuong, Huynh, Jacqueline, Miller, Hana M, El Sahly, Lindsey R, Baden, Mira, Baron, Luis, De La Cruz, Cynthia, Gay, Spyros, Kalams, Colleen F, Kelley, Michele P, Andrasik, James G, Kublin, Lawrence, Corey, Kathleen M, Neuzil, Lindsay N, Carpp, Rolando, Pajon, Dean, Follmann, Ruben O, Donis, Richard A, Koup
Publikováno v:
Science. 375:43-50
Antibody levels predict vaccine efficacy Symptomatic COVID-19 infection can be prevented by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) vaccines. A “correlate of protection” is a molecular biomarker to measure how much immunity i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cc22f4d0da06c2d43b284913744b8080
https://doi.org/10.1126/science.abm3425
https://doi.org/10.1126/science.abm3425
Autor:
Tina Guina, Lynda L. Lanning, Kristian S. Omland, Mark S. Williams, Larry A. Wolfraim, Stephen P. Heyse, Christopher R. Houchens, Patrick Sanz, Judith A. Hewitt
Publikováno v:
Frontiers in Cellular and Infection Microbiology, Vol 8 (2018)
Francisella tularensis is a highly infectious Gram-negative bacterium that is the etiologic agent of tularemia in animals and humans and a Tier 1 select agent. The natural incidence of pneumonic tularemia worldwide is very low; therefore, it is not f
Externí odkaz:
https://doaj.org/article/dcbf1003b6114ee2ac83127c33047359
Autor:
Youyi, Fong, Adrian B, McDermott, David, Benkeser, Sanne, Roels, Daniel J, Stieh, An, Vandebosch, Mathieu, Le Gars, Griet A, Van Roey, Christopher R, Houchens, Karen, Martins, Lakshmi, Jayashankar, Flora, Castellino, Obrimpong, Amoa-Awua, Manjula, Basappa, Britta, Flach, Bob C, Lin, Christopher, Moore, Mursal, Naisan, Muhammed, Naqvi, Sandeep, Narpala, Sarah, O'Connell, Allen, Mueller, Leo, Serebryannyy, Mike, Castro, Jennifer, Wang, Christos J, Petropoulos, Alex, Luedtke, Ollivier, Hyrien, Yiwen, Lu, Chenchen, Yu, Bhavesh, Borate, Lars W P, van der Laan, Nima S, Hejazi, Avi, Kenny, Marco, Carone, Daniel N, Wolfe, Jerald, Sadoff, Glenda E, Gray, Beatriz, Grinsztejn, Paul A, Goepfert, Susan J, Little, Leonardo, Paiva de Sousa, Rebone, Maboa, April K, Randhawa, Michele P, Andrasik, Jenny, Hendriks, Carla, Truyers, Frank, Struyf, Hanneke, Schuitemaker, Macaya, Douoguih, James G, Kublin, Lawrence, Corey, Kathleen M, Neuzil, Lindsay N, Carpp, Dean, Follmann, Peter B, Gilbert, Richard A, Koup, Ruben O, Donis
Publikováno v:
Nature microbiology. 7(12)
Measuring immune correlates of disease acquisition and protection in the context of a clinical trial is a prerequisite for improved vaccine design. We analysed binding and neutralizing antibody measurements 4 weeks post vaccination as correlates of r
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::43118061614e503632a84f1faf847fce
https://pubmed.ncbi.nlm.nih.gov/35441174
https://pubmed.ncbi.nlm.nih.gov/35441174