Zobrazeno 1 - 10
of 6 172
pro vyhledávání: '"R, Horton"'
Autor:
Chloe L. Barrington, Gabriel Galindo, Amanda L. Koch, Emma R. Horton, Evan J. Morrison, Samantha Tisa, Timothy J. Stasevich, Olivia S. Rissland
Publikováno v:
Cell Reports, Vol 42, Iss 12, Pp 113413- (2023)
Summary: Nonoptimal synonymous codons repress gene expression, but the underlying mechanisms are poorly understood. We and others have previously shown that nonoptimal codons slow translation elongation speeds and thereby trigger messenger RNA (mRNA)
Externí odkaz:
https://doaj.org/article/b3483aeae2a8422cb39ab1f4d60698c3
Autor:
Amit A. Upadhyay, Elise G. Viox, Timothy N. Hoang, Arun K. Boddapati, Maria Pino, Michelle Y.-H. Lee, Jacqueline Corry, Zachary Strongin, David A. Cowan, Elizabeth N. Beagle, Tristan R. Horton, Sydney Hamilton, Hadj Aoued, Justin L. Harper, Christopher T. Edwards, Kevin Nguyen, Kathryn L. Pellegrini, Gregory K. Tharp, Anne Piantadosi, Rebecca D. Levit, Rama R. Amara, Simon M. Barratt-Boyes, Susan P. Ribeiro, Rafick P. Sekaly, Thomas H. Vanderford, Raymond F. Schinazi, Mirko Paiardini, Steven E. Bosinger
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-16 (2023)
‘The induction and coordination of immune cells in response to SARS-CoV-2 infection are critical in the immunopathology of COVID-19. Here the authors use a rhesus macaque model of SARS-CoV-2 infection and show key populations of macrophage drive th
Externí odkaz:
https://doaj.org/article/c564e47315c745239eaae99118b06bd0
Autor:
Kylie D. Swisher Grimm, David R. Horton, Tamera M. Lewis, Stephen F. Garczynski, Andrew S. Jensen, Brian A. Charlton
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-15 (2022)
Abstract Eleven haplotypes of the bacterium, ‘Candidatus Liberibacter solanacearum’, have been identified worldwide, several of which infect important agricultural crops. In the United States, haplotypes A and B are associated with yield and qual
Externí odkaz:
https://doaj.org/article/fa4b640834fb4bc08ceb3a370d3d0b61
Autor:
Jujun Zhou, John R. Horton, Dan Yu, Ren Ren, Robert M. Blumenthal, Xing Zhang, Xiaodong Cheng
Publikováno v:
Epigenetics, Vol 17, Iss 9, Pp 970-981 (2022)
Epigenetically targeted therapeutic development, particularly for SAM-dependent methylations of DNA, mRNA and histones has been proceeding rapidly for cancer treatments over the past few years. However, this approach has barely begun to be exploited
Externí odkaz:
https://doaj.org/article/5a7bb73e66d04b97acf84d95ef8faf4c
Autor:
Maria Rafaeva, Adina R. D. Jensen, Edward R. Horton, Kamilla W. Zornhagen, Jan E. Strøbech, Lutz Fleischhauer, Alejandro E. Mayorca-Guiliani, Sebastian R. Nielsen, Dina S. Grønseth, Filip Kuś, Erwin M. Schoof, Luis Arnes, Manuel Koch, Hauke Clausen-Schaumann, Valerio Izzi, Raphael Reuten, Janine T. Erler
Publikováno v:
Frontiers in Immunology, Vol 14 (2023)
The desmoplastic reaction observed in many cancers is a hallmark of disease progression and prognosis, particularly in breast and pancreatic cancer. Stromal-derived extracellular matrix (ECM) is significantly altered in desmoplasia, and as such plays
Externí odkaz:
https://doaj.org/article/1b359b8013e44394a924f6031f8d7cb2
Autor:
Kevin M. Motz, Ioan A. Lina, Idris Samad, Michael K. Murphy, Madhavi Duvvuri, Ruth J. Davis, Alexander Gelbard, Liam Chung, Yee Chan-Li, Samuel Collins, Jonathan D. Powell, Jennifer H. Elisseeff, Maureen R. Horton, Alexander T. Hillel
Publikováno v:
JCI Insight, Vol 8, Iss 11 (2023)
Laryngotracheal stenosis (LTS) is pathologic fibrotic narrowing of the larynx and trachea characterized by hypermetabolic fibroblasts and CD4+ T cell–mediated inflammation. However, the role of CD4+ T cells in promoting LTS fibrosis is unknown. The
Externí odkaz:
https://doaj.org/article/89ce5a887c6b4f738d6058bd9b2c232a
Autor:
David R. Horton
Publikováno v:
Insects, Vol 15, Iss 1, p 37 (2024)
The pear psyllids (Cacopsylla spp.; Psylloidea) comprise ~24 species of sap-feeding insects distributed in Europe, temperate Asia, and (as introductions) in the Americas. These pear-specialized insects are among the most damaging and difficult to con
Externí odkaz:
https://doaj.org/article/e50c0948d1f44a2386ceddbd1ff83e05
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-12 (2021)
Clostridioides difficile adenine methyltransferase A (CamA) is required for the sporulation and colonization of the pathogen that causes gastrointestinal infections. Here, the authors characterise CamA kinetically and present its crystal structure bo
Externí odkaz:
https://doaj.org/article/72d81f7c9e58495889a373df8da8fa71
Autor:
Sebastian R. Nielsen, Jan E. Strøbech, Edward R. Horton, Rene Jackstadt, Anu Laitala, Marina C. Bravo, Giorgia Maltese, Adina R. D. Jensen, Raphael Reuten, Maria Rafaeva, Saadia A. Karim, Chang-Il Hwang, Luis Arnes, David A. Tuveson, Owen J. Sansom, Jennifer P. Morton, Janine T. Erler
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-15 (2021)
Tumor associated neutrophils have been correlated with poor prognosis in patients with pancreatic ductal adenocarcinoma (PDAC). Here the authors show that the tyrosine kinase inhibitor lorlatinib modulates neutrophil development and recruitment in th
Externí odkaz:
https://doaj.org/article/80c3347050694832b4503df3a10d5b8d
Autor:
Zhen Fu, Amanda R. Meier, Brendan Epstein, Alan O. Bergland, Carmen I. Castillo Carrillo, William R. Cooper, Regina K. Cruzado, David R. Horton, Andrew S. Jensen, Joanna L. Kelley, Arash Rashed, Stuart R. Reitz, Silvia I. Rondon, Jenita Thinakaran, Erik J. Wenninger, Carrie H. Wohleb, David W. Crowder, William E. Snyder
Publikováno v:
Evolutionary Applications, Vol 13, Iss 10, Pp 2740-2753 (2020)
Abstract Changing climate and land‐use practices have the potential to bring previously isolated populations of pest insects into new sympatry. This heightens the need to better understand how differing patterns of host–plant association, and uni
Externí odkaz:
https://doaj.org/article/0a2c7e8d9b07408eaa3d074911d7dc3d