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Autor:
N. D. Volkow, G. -J. Wang, S. J. Gatley, J. S. Fowler, Y. -S. Ding, J. Logan, R. Hitzemann, B. Angrist, J. Lieberman
Publikováno v:
Psychopharmacology. 123:26-33
Positron emission tomography was used to compare the pharmacokinetics of [11C]methylphenidate in the human brain with the temporal course of the subjective and cardiovascular effects observed after intravenous methylphenidate (0.5 mg/kg). Four subjec
Publikováno v:
ChemInform. 22
Publikováno v:
ChemInform. 23
Autor:
R. Hitzemann, H.‐J. Knoelker
Publikováno v:
ChemInform. 25
Autor:
L A, Adler, J, Rotrosen, R, Edson, P, Lavori, J, Lohr, R, Hitzemann, D, Raisch, M, Caligiuri, K, Tracy
Publikováno v:
Archives of general psychiatry. 56(9)
Several short-term, controlled trials have documented the efficacy of vitamin E in treating tardive dyskinesia. However, the persistent nature of the disease prompted us to perform a multicenter, longer-term trial of vitamin E.The study was a prospec
Autor:
R, Hitzemann, B, Malmanger, S, Cooper, S, Coulombe, C, Reed, K, Demarest, J, Koyner, L, Cipp, J, Flint, C, Talbot, B, Rademacher, K, Buck, J, McCaughran
Publikováno v:
Genes, brain, and behavior. 1(4)
This study examines the use of multiple cross mapping (MCM) to reduce the interval for an ethanol response QTL on mouse chromosome 1. The phenotype is the acute locomotor response to a 1.5-g/kg i.p. dose of ethanol. The MCM panel consisted of the six
Autor:
P K, Thanos, N D, Volkow, P, Freimuth, H, Umegaki, H, Ikari, G, Roth, D K, Ingram, R, Hitzemann
Publikováno v:
Journal of neurochemistry. 78(5)
The mechanism(s) underlying predisposition to alcohol abuse are poorly understood but may involve brain dopamine system(s). Here we used an adenoviral vector to deliver the dopamine D2 receptor (DRD2) gene into the nucleus accumbens of rats, previous
Publikováno v:
Behavior genetics. 31(1)
Differential sensitivity to the stimulant effects of ethanol on locomotor activity is determined in part by genetic differences. Among inbred strains of mice, moderate doses of ethanol (1-2 g/kg) stimulate locomotor activity in some strains, e.g., th
Autor:
R, Hitzemann
Publikováno v:
Alcohol Research & Health
Animal models are important tools in the study of psychiatric disorders, including alcoholism,1 because they allow the use of research methods that cannot be used for ethical reasons in humans. Consequently, scientists have developed numerous approac