Mutation analysis of components of the Mediator kinase module in MED12 mutation-negative uterine leiomyomas

Autor: Jussi Taipale, Pia Vahteristo, H-R Heinonen, Jari Sjöberg, Lauri A. Aaltonen, Netta Mäkinen

Publikováno v: British Journal of Cancer

Background: Kinase module of Mediator complex (‘CDK8 submodule') consists of four subunits: CDK8, Cyclin C, MED12, and MED13. Recently, we reported recurrent MED12 mutations in 70% of uterine leiomyomas. The aim of this study was to analyse whether

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dedf48d5ef3a9c3b7b64c6a6d7adb5bf
https://doi.org/10.1038/bjc.2014.138

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Autor: E.M. Tukahirwa, R. Heinonen, G. Musisi, E. Bode, J. Okello-Onen, J. Opuda-Asibo, S.N. Nagda, G.J. Rowlands, Brian D. Perry, W. T. Mwayi

Publikováno v: Tropical Animal Health and Production. 35:237-247

The impact of tick control on the productivity of indigenous cattle was investigated in three herds of East African shorthorn Zebu and Zebu x Ankole (Nganda) breeds, maintained under three tick management systems practised under ranch conditions: twi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::7ee829060ba05b06b859b7e5ffbf9569
https://doi.org/10.1023/a:1023395413568

Somatic MED12 mutations in uterine leiomyosarcoma and colorectal cancer

Autor: Tom Böhling, Peter Hokland, Ralf Bützow, H-R Heinonen, Lauri A. Aaltonen, Pia Vahteristo, Johanna Arola, Miika Mehine, Netta Mäkinen, Heli J. Lehtonen, Omar Abdel-Wahab, H. Schrewe, Jan Böhm, Mecklin Jp, Kati Kämpjärvi, Ross L. Levine, Heli Nevanlinna, Outi Kilpivaara, Liisa M. Pelttari

Publikováno v: British Journal of Cancer
Kämpjärvi, K, Mäkinen, N, Kilpivaara, O, Arola, J, Heinonen, H-R, Böhm, J, Abdel-Wahab, O, Lehtonen, H J, Pelttari, L M, Mehine, M, Schrewe, H, Nevanlinna, H, Levine, R L, Hokland, P, Böhling, T, Mecklin, J-P, Bützow, R, Aaltonen, L A & Vahteristo, P 2012, ' Somatic MED12 mutations in uterine leiomyosarcoma and colorectal cancer ', B J C, vol. 107, no. 10, pp. 1761-5 . https://doi.org/10.1038/bjc.2012.428

Background: Mediator complex participates in transcriptional regulation by connecting regulatory DNA sequences to the RNA polymerase II initiation complex. Recently, we discovered through exome sequencing that as many as 70% of uterine leiomyomas har

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a77e4d3382cf7435691f7f506e83631e

The impact of tick control on the productivity of indigenous cattle under ranch conditions in Uganda

Autor: J, Okello-Onen, E M, Tukahirwa, B D, Perry, G J, Rowlands, S N, Nagda, G, Musisi, E, Bode, R, Heinonen, W, Mwayi, J, Opuda-Asibo

Publikováno v: Tropical animal health and production. 35(3)

The impact of tick control on the productivity of indigenous cattle was investigated in three herds of East African shorthorn Zebu and Zebu x Ankole (Nganda) breeds, maintained under three tick management systems practised under ranch conditions: twi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::fbc0e56d763cada9a7833c2f03c12d8d
https://pubmed.ncbi.nlm.nih.gov/12797413

Population dynamics of ticks on indigenous cattle in a pastoral dry to semi-arid rangeland zone of Uganda

Autor: J, Okello-Onen, E M, Tukahirwa, B D, Perry, G J, Rowlands, S M, Nagda, G, Musisi, E, Bode, R, Heinonen, W, Mwayi, J, Opuda-Asibo

Publikováno v: Experimentalapplied acarology. 23(1)

Studies on seasonality and population dynamics of ticks on indigenous cattle and their crosses (calves) were carried out in Buruli Ranching Scheme, Nabiswera, Luwero district of Uganda on three treatment groups of animals: group 1 (twice a week dippi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::db65d61c9689354dd1c8a6b7ffdd986d
https://pubmed.ncbi.nlm.nih.gov/10353189